Immunology Practice Test 8
Immunology NCLEX Practice Test
Immunology is a key topic within the NCLEX test plan, located under Nursing Science → Clinical Foundations → Immunology. This section covers immune defense, hypersensitivity, and immunotherapy monitoring within nursing scope. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 8th part of the Immunology series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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In the Immunology Study Cards section, shared by real NCLEX candidates, you’ll find concise summaries and high-yield insights related to the most tested concepts. It’s a perfect space to reinforce challenging topics and sharpen your recall through quick, focused repetitions. Short, powerful, and repeatable!
Immunology Practice Test 8
A client is brought to the emergency unit with chest tightness and audible wheezing after exposure to pollen. Which antibodies are responsible for this presentation?
- Ig G
- Ig A
- Ig E
- Ig M
Explanation: Answer reason: Allergen cross-linking of IgE triggers degranulation with histamine and leukotrienes, causing bronchoconstriction, mucus production, and wheezing. This mechanism best explains acute chest tightness and audible wheeze after allergen exposure. IgG is more associated with secondary immune responses and some type II/III hypersensitivity processes rather than classic atopy/asthma. IgA is primarily mucosal protection and IgM is an early-response antibody, neither of which drives immediate allergic bronchospasm.
Which blood cells are involved in immune response?
- Red blood cells
- White blood cells
- Platelets
- Plasma cells
Explanation: Answer reason: Neutrophils and macrophages provide rapid phagocytic defense, while lymphocytes (T cells and B cells) drive antigen-specific immunity and immunologic memory. Red blood cells mainly transport oxygen and carbon dioxide and do not perform immune surveillance or effector functions. Platelets primarily function in hemostasis, and plasma cells are differentiated B lymphocytes rather than the broad blood-cell category responsible for overall immune responses.
What is the primary hormone responsible for the regulation of the body's response to infection and inflammation?
- Parathyroid hormone (PTH)
- Calcitonin
- Thyroid-stimulating hormone (TSH)
- Interleukin-1 (IL-1)
Explanation: Answer reason: IL-1 is a key proinflammatory mediator that promotes fever, leukocyte activation, endothelial adhesion molecule expression, and acute-phase responses, making it central to systemic regulation during infection and inflammation. In contrast, PTH and calcitonin primarily regulate calcium/phosphate homeostasis, and TSH regulates thyroid hormone production rather than immune signaling. Therefore, the only option that directly fits immune regulation of inflammation is the cytokine IL-1.
Which system is responsible for fighting infections?
- Nervous system
- Circulatory system
- Immune system
- Digestive system
Explanation: Answer reason: This includes physical and cellular barriers, inflammation, phagocytosis, and targeted responses via B cells (antibodies) and T cells (cell-mediated immunity). These coordinated mechanisms recognize, neutralize, and eliminate infectious organisms and create immunologic memory to reduce future infection risk. The circulatory system helps transport immune cells and mediators but is not the system whose core function is infection control.
Lymphocytes are related to ...?
- Clotting
- Immunity
- Respiration
- Excretion
Explanation: Answer reason: B lymphocytes differentiate into plasma cells that produce antibodies, while T lymphocytes provide cell-mediated immunity and immune regulation. This directly links them to immune responses rather than organ functions like respiration or excretion. Clotting is primarily mediated by platelets and coagulation factors, not lymphocytes.
A nurse practicing in a nurse-managed clinic suspects that an 8 year-old child's chronic sinusitis and upper respiratory tract infections may result from allergies. She orders an immunoglobulin assay. Which immunoglobulin would the nurse expect to find elevated?
- Immunoglobulin G
- Immunoglobulin M
- Immunoglobulin E
- Immunoglobulin D
Explanation: Answer reason: With allergen exposure, IgE cross-linking triggers release of histamine and other mediators, producing allergic rhinitis/sinus inflammation that can predispose to recurrent upper respiratory symptoms. IgG is primarily a marker of past exposure and long-term humoral immunity, not classic atopy. IgM reflects early primary immune responses, and IgD is mainly a B-cell surface receptor, so neither would be expected to rise as the key immunoglobulin in allergy.
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