Endocrine System Practice Test 8
Endocrine System NCLEX Practice Test
Endocrine System is a key topic within the NCLEX test plan, located under Nursing Science → Clinical Foundations → Endocrine System. This section reviews hormonal regulation and nursing priorities in metabolic and endocrine disorders. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 8th part of the Endocrine System series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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In the Endocrine System Study Cards section, shared by real NCLEX candidates, you’ll find concise summaries and high-yield insights related to the most tested concepts. It’s a perfect space to reinforce challenging topics and sharpen your recall through quick, focused repetitions. Short, powerful, and repeatable!
Endocrine System Practice Test 8
Diabetes is controlled by?
- Adrenaline
- Thyroxine
- Insulin
Explanation: Answer reason: Diabetes mellitus is characterized by impaired insulin secretion and/or insulin action, leading to hyperglycemia. Insulin is the primary hormone that lowers blood glucose by facilitating cellular glucose uptake and suppressing hepatic glucose production. Adrenaline and thyroxine tend to increase blood glucose or metabolic rate rather than control diabetes.
Which gland is also known as the “third eye”?
- Pituitary
- Pineal
- Parathyroid
- Thymus
Explanation: Answer reason: The pineal gland is traditionally referred to as the “third eye” because it is photosensitive in many species and, in humans, helps regulate circadian rhythms via melatonin secretion. Melatonin production is influenced by light exposure transmitted through the retina and hypothalamic pathways. The pituitary is the “master gland,” the parathyroids regulate calcium via PTH, and the thymus is involved in T-cell maturation, so they do not fit the “third eye” description.
Insulin is secreted by?
- Liver
- Bone marrow
- Pituitary gland
- Pancreas
Explanation: Answer reason: Insulin is produced by beta (β) cells located in the islets of Langerhans of the pancreas. It is the primary anabolic hormone that lowers blood glucose by promoting cellular glucose uptake and glycogen synthesis. The liver responds to insulin but does not secrete it; bone marrow and the pituitary gland are not sources of insulin.
Insulin is used to treat?
- Cough
- Fever
- Malaria
- Diabetes
Explanation: Answer reason: Insulin is a pancreatic hormone used as a medication to lower blood glucose by promoting cellular glucose uptake and inhibiting hepatic glucose output. It is essential in type 1 diabetes and is also used in type 2 diabetes when endogenous insulin is insufficient or during acute hyperglycemic crises. It is not a treatment for infections like malaria, nor for nonspecific symptoms such as cough or fever.
Insulin is secreted by which cells of Pancreas?
- Gamma cells
- Alpha cells
- Beta cells
- Delta cells
Explanation: Answer reason: Insulin is produced by the pancreatic beta (β) cells located in the islets of Langerhans. Beta cells secrete insulin in response to elevated blood glucose to promote cellular glucose uptake and storage. In contrast, alpha cells secrete glucagon and delta cells secrete somatostatin, making beta cells the correct choice.
What is the term for low blood glucose ...?
- Hyponatremia.
- Hypokalemia.
- Hypoglycemia.
- Hypoxia
Explanation: Answer reason: Low blood glucose is termed hypoglycemia (typically <70 mg/dL). Hyponatremia and hypokalemia refer to low serum sodium and potassium, respectively, not glucose. Hypoxia refers to low oxygen levels in tissues or blood. Therefore, the correct term for low blood glucose is hypoglycemia.
Which organ produces hormones that regulate metabolism and energy levels?
- Thyroid
- Pancreas
- Adrenal glands
- Pituitary gland
Explanation: Answer reason: The thyroid gland produces thyroid hormones (T3 and T4), which set the body’s basal metabolic rate and strongly influence energy expenditure, heat production, and overall metabolism. When thyroid hormone levels rise, metabolism and energy use increase; when they fall, metabolism slows and fatigue can occur. The pancreas primarily regulates blood glucose (insulin/glucagon), adrenal glands mainly mediate stress responses (cortisol/epinephrine), and the pituitary largely regulates other endocrine glands rather than directly controlling metabolic rate.
Which of the following is a risk factor for Type 2 DM?
- Viral infection
- Autoimmune disorder
- Obesity
- Low blood pressure
Explanation: Answer reason: Obesity is a major modifiable risk factor for type 2 diabetes mellitus because excess adipose tissue (especially visceral fat) promotes insulin resistance through inflammatory mediators and altered adipokine signaling. Over time, insulin resistance increases pancreatic beta-cell workload and contributes to beta-cell dysfunction, leading to hyperglycemia. Viral infection and autoimmune disorders are more associated with type 1 diabetes pathogenesis, and low blood pressure is not a recognized risk factor for type 2 DM.
In human body pituitary gland is situated in?
- Neck
- Brain
- Kidney
- Abdomen
Explanation: Answer reason: The pituitary gland is located at the base of the brain within the sella turcica of the sphenoid bone and is connected to the hypothalamus via the pituitary stalk. It functions as the “master gland,” secreting hormones that regulate other endocrine glands and many body processes. Therefore, among the options given, the correct location is the brain.
__________ is milky breast discharge that happens in women who aren't pregnant or breastfeeding?
- Leukorrhea
- Menorrhagia
- Galactorrhea
- Amenorrhea
Explanation: Answer reason: Galactorrhea is defined as milky nipple discharge unrelated to pregnancy or lactation. It is commonly due to hyperprolactinemia, such as from a pituitary prolactinoma or dopamine-antagonist medications. The other options refer to vaginal discharge (leukorrhea) or menstrual abnormalities (menorrhagia, amenorrhea), not breast milk secretion.
Male breast enlargement is known as?
- Mastitis
- Fibroadenoma
- Gynecomastia
- Lipoma
Explanation: Answer reason: Male breast enlargement due to proliferation of glandular breast tissue is termed gynecomastia, commonly related to an imbalance of estrogen and androgen effects. Mastitis refers to inflammatory/infectious changes of breast tissue, usually presenting with pain, erythema, and systemic signs. Fibroadenoma is a benign breast tumor classically seen in females, and lipoma is a benign fatty tumor rather than glandular breast enlargement.
Anti-Diuretic Hormone also know as ...?
- Testosterone
- Progesterone
- Vasopressin
- Oxytocin
Explanation: Answer reason: Antidiuretic hormone (ADH) is also called vasopressin. It is synthesized in the hypothalamus and released from the posterior pituitary, where it increases water reabsorption in the kidney collecting ducts via V2 receptors. This decreases urine output and helps regulate plasma osmolality and blood pressure. Testosterone, progesterone, and oxytocin are different hormones with distinct functions.
A patient’s fasting blood glucose level is measured at 160mg/dl this condition referred to us?
- Hyperglycemia
- Hypoglycemia
- Normoglycemia
Explanation: Answer reason: A fasting blood glucose of 160 mg/dL is above the normal fasting range (typically ~70–99 mg/dL) and exceeds the diagnostic threshold for diabetes (≥126 mg/dL on fasting testing). Therefore, the condition is elevated blood glucose, i.e., hyperglycemia. Hypoglycemia refers to low glucose (commonly <70 mg/dL), and normoglycemia refers to normal levels.
Which organ produces insulin?
- Liver
- Pancreas
- Kidney
- Stomach
Explanation: Answer reason: Insulin is produced by beta (β) cells in the islets of Langerhans of the pancreas. It is released in response to elevated blood glucose and promotes glucose uptake by tissues while decreasing hepatic glucose output. The liver responds to insulin but does not produce it; kidneys and stomach also do not synthesize insulin as their primary endocrine function.
Which hormone surge triggers ovulation?
- LH
- FSH
- Estrogen
- Progesterone
Explanation: Answer reason: Ovulation is triggered by the mid-cycle surge of luteinizing hormone (LH) from the anterior pituitary, which causes the dominant follicle to rupture and release the oocyte. FSH primarily supports follicular growth and maturation rather than initiating follicle rupture. Rising estrogen from the maturing follicle creates positive feedback on the hypothalamus/pituitary that induces the LH surge. Progesterone increases after ovulation from the corpus luteum and supports the luteal phase, not the ovulatory trigger.
A patient with a traumatic brain injury (TBI) is MOST likely to suffer from what condition?
- Diabetes mellitus
- Cerebral palsy
- Diabetes Insipidus
- Myxedema coma
Explanation: Answer reason: Traumatic brain injury can damage the hypothalamus or posterior pituitary, disrupting antidiuretic hormone (ADH) production or release. This leads to central diabetes insipidus, characterized by inability to concentrate urine with polyuria and resulting hypernatremia/dehydration risk. Diabetes mellitus is pancreatic/insulin related, cerebral palsy is a non-acute neurodevelopmental disorder, and myxedema coma results from severe hypothyroidism rather than TBI.
Which hormone is secreted by the anterior pituitary gland?
- Cortisol
- Anti-diuretic hormone
- Corticotropin
- Oxytocin
Explanation: Answer reason: The anterior pituitary secretes tropic hormones including ACTH (corticotropin), which stimulates the adrenal cortex to produce cortisol. Cortisol itself is produced by the adrenal cortex, not the pituitary. Anti-diuretic hormone (ADH) and oxytocin are released from the posterior pituitary (synthesized in the hypothalamus). Therefore, corticotropin is the only anterior pituitary hormone listed.
Hyperglycemia occurs due to?
- Increased insulin
- Insulin resistance
- Decreased insulin
- Over weight
Explanation: Answer reason: Hyperglycemia results when there is insufficient effective insulin to promote glucose uptake by skeletal muscle and adipose tissue and to suppress hepatic glucose output. A decrease in insulin (absolute deficiency, as in type 1 diabetes, or relative deficiency) directly causes elevated blood glucose. Insulin resistance can also cause hyperglycemia, but the question asks for the best single cause; decreased insulin is the most direct mechanism. Overweight is a risk factor for insulin resistance rather than an immediate physiologic cause.
When teaching a group of adolescents about male hormone production, which of the following would the nurse include as being produced by the Leydig cells?
- Follicle-stimulating hormone
- Testosterone
- Luteinizing hormone
- Gonadotropin releasing hormone
Explanation: Answer reason: Leydig (interstitial) cells in the testes synthesize and secrete testosterone in response to luteinizing hormone stimulation. Follicle-stimulating hormone primarily acts on Sertoli cells to support spermatogenesis rather than being produced by testicular cells. Luteinizing hormone and gonadotropin-releasing hormone are produced in the anterior pituitary and hypothalamus, respectively, not by Leydig cells. Therefore, testosterone is the correct choice.
The Hot Flushes can be seen in the ___?
- Pregnant mother
- Post-natal mother
- Menopausal woman
- Adolescent girl
Explanation: Answer reason: Hot flushes (vasomotor symptoms) are classically associated with menopause due to declining ovarian estrogen production and hypothalamic thermoregulatory instability. This estrogen withdrawal leads to episodic vasodilation, sweating, and a sudden sensation of heat. While postpartum or pregnancy involve hormonal shifts, recurrent hot flushes are most characteristic of the menopausal transition. Therefore, the best answer is menopausal woman.
Growth Hormone releasing hormone is produced by?
- Anterior pituitary
- Posterior pituitary
- Hypothalamus
- Thyroid gland
Explanation: Answer reason: Growth hormone–releasing hormone (GHRH) is synthesized in the hypothalamus and delivered to the anterior pituitary via the hypophyseal portal circulation. It stimulates somatotrophs in the anterior pituitary to secrete growth hormone. The posterior pituitary primarily stores/releases hypothalamic ADH and oxytocin, and the thyroid gland produces thyroid hormones, not hypothalamic releasing hormones.
Which condition may require emergency administration of hydrocortisone injection?
- Diabetes
- Adrenal crisis
- Hypertension
- Anemia
Explanation: Answer reason: An adrenal crisis (acute adrenal insufficiency) is a life-threatening emergency caused by critically low cortisol levels, often presenting with hypotension/shock, dehydration, and hypoglycemia. Immediate IV/IM hydrocortisone is the standard urgent treatment to replace glucocorticoid (and provide some mineralocorticoid) activity while fluids and supportive care are started. Diabetes, hypertension, and anemia do not typically require emergent hydrocortisone as definitive therapy. Therefore, adrenal crisis is the best indication for emergency hydrocortisone injection.
Estrogen in girls is mainly produced by?
- Adrenal glands
- Pituitary gland
- Ovarian follicles
- Hypothalamus
Explanation: Answer reason: In girls and reproductive-age females, the primary source of circulating estrogens is the ovaries, especially granulosa cells of developing ovarian follicles, which aromatize androgens into estradiol. The adrenal glands mainly produce androgen precursors that can be peripherally converted to estrogens but are not the main source. The pituitary and hypothalamus regulate ovarian estrogen production via FSH/LH and GnRH, respectively, but they do not primarily synthesize estrogen.
Which of the following is not a steroid hormone?
- Estrogen
- Cortisol
- Insulin
- Aldosterone
Explanation: Answer reason: Insulin is a peptide (protein) hormone synthesized as preproinsulin in pancreatic beta cells and acts via cell-surface receptors. Steroid hormones are cholesterol-derived, lipid-soluble hormones that typically bind intracellular receptors and influence gene transcription. Estrogen, cortisol, and aldosterone are all steroid hormones produced from cholesterol (gonads/placenta and adrenal cortex). Therefore, insulin is the only option that is not a steroid hormone.
A 36yr old female has gestational diabetes. Her baby is at increased risk to have all of the following except?
- Preterm birth
- Macrosomia
- Hyperglycemia soon after birth
- Respiratory distress after birth
Explanation: Answer reason: Infants of mothers with gestational diabetes are exposed to maternal hyperglycemia in utero, which stimulates fetal pancreatic beta cells and leads to fetal hyperinsulinemia. After delivery, the maternal glucose supply stops abruptly while insulin levels remain high, predisposing the newborn to hypoglycemia (not hyperglycemia). Gestational diabetes is also associated with macrosomia and increased risk of preterm birth and neonatal respiratory distress. Therefore, the exception is hyperglycemia soon after birth.
What is the main cause of kidney failure?
- Smoking
- Dehydration
- Diabetes
Explanation: Answer reason: Diabetes mellitus is the leading cause of chronic kidney disease and end-stage kidney failure in many populations due to diabetic nephropathy. Chronic hyperglycemia causes glomerular hyperfiltration, progressive albuminuria, and glomerulosclerosis, leading to irreversible loss of nephron function over time. Dehydration can cause acute kidney injury from reduced renal perfusion but is not the most common overall cause of kidney failure. Smoking increases kidney disease risk and progression but is not the primary leading cause compared with diabetes.
Egg production stops after?
- Puberty
- Menopause
- Gestation
- Ovulation
Explanation: Answer reason: Ovarian follicular activity and ovulation cease permanently after menopause due to depletion of functional follicles and reduced ovarian responsiveness, resulting in marked declines in estrogen and progesterone. Puberty initiates ovulatory cycles rather than stopping them. Gestation suppresses ovulation temporarily but does not end egg production permanently. Ovulation is the monthly release of an oocyte, not a point at which production stops.
Which gland is called the master gland of the body?
- Thyroid gland
- Adrenal gland
- Pituitary gland
- Pineal gland
Explanation: Answer reason: The pituitary gland is considered the “master gland” because it secretes tropic hormones (e.g., TSH, ACTH, LH/FSH) that regulate the activity of other endocrine glands such as the thyroid, adrenal cortex, and gonads. Under hypothalamic control, it coordinates growth, metabolism, reproduction, and stress responses. While the thyroid, adrenal, and pineal glands have important functions, they are not the primary central regulators of other endocrine glands in the same way.
In Diabetes disease the urine contains ?
- Salt
- Fat
- Protein
- Sugar
Explanation: Answer reason: In diabetes mellitus, blood glucose can rise above the renal threshold, causing glucose to spill into the urine (glycosuria). This occurs because renal tubular reabsorption becomes saturated when plasma glucose is sufficiently elevated. Glycosuria is a classic finding in uncontrolled diabetes and contributes to osmotic diuresis, leading to polyuria and dehydration. The other listed substances are not the hallmark routine urine finding for diabetes.
Diabetes insipidus is caused by deficiency of?
- Adh
- Insulin
- Glucagon
- Aldosterone
Explanation: Answer reason: Diabetes insipidus is most commonly due to deficiency of antidiuretic hormone (ADH) from the posterior pituitary (central DI) or renal resistance to ADH (nephrogenic DI). Lack of effective ADH prevents water reabsorption in the renal collecting ducts, leading to excretion of large volumes of dilute urine and compensatory polydipsia. Insulin deficiency causes diabetes mellitus, while glucagon and aldosterone are not the primary hormones responsible for the classic presentation of diabetes insipidus.
Iodine is the main part of which hormones?
- Oxytocin
- Thyroxin
- Thyroid
- None
Explanation: Answer reason: Iodine is an essential component of thyroid hormones, which are synthesized by iodination of tyrosine residues in thyroglobulin. Thyroxine (T4) specifically contains four iodine atoms, making iodine a key structural part of the hormone. Oxytocin is a peptide hormone and does not contain iodine, and "thyroid" is a gland rather than a hormone. Therefore, the best answer is thyroxin.
The primary site for estrogen production in premenopausal women is?
- Liver
- Adrenal cortex
- Ovary
- Placenta
Explanation: Answer reason: In premenopausal women, the ovaries are the main source of estrogen (especially estradiol), produced primarily by granulosa cells of developing follicles under FSH/LH regulation. The adrenal cortex produces androgen precursors that can be peripherally converted to estrogen, but this is not the primary source before menopause. The placenta becomes a major estrogen source only during pregnancy. The liver is involved in metabolism and conjugation of hormones rather than primary estrogen production.
Destruction of Anterior pituitary gland causes decrease functioning of which of the following?
- Zona granulosa
- Adrenal medulla
- Zona fasciculata
- Medulla
Explanation: Answer reason: The anterior pituitary secretes ACTH, which trophically stimulates the adrenal cortex—especially the zona fasciculata—to produce cortisol. Destruction of the anterior pituitary lowers ACTH, leading to adrenal cortical atrophy and decreased cortisol output, so zona fasciculata function decreases. Zona glomerulosa (listed as “zona granulosa”) is primarily regulated by the renin-angiotensin-aldosterone system and potassium, and the adrenal medulla is regulated mainly by sympathetic innervation rather than pituitary hormones.
Type 1 Diabetes Mellitus is caused by?
- Insulin resistance
- Overeating
- Autoimmune destruction of beta cells
- Increased insulin production
Explanation: Answer reason: Type 1 diabetes mellitus results from autoimmune-mediated destruction of pancreatic beta cells, leading to an absolute insulin deficiency. This process commonly involves autoantibodies (e.g., GAD, IA-2) and progressive loss of insulin secretion. In contrast, insulin resistance is the hallmark of type 2 diabetes, and overeating is a risk factor more associated with type 2 via obesity/insulin resistance. Increased insulin production would not cause hyperglycemia and is inconsistent with type 1 DM pathogenesis.
Which hormone is important for fight and flight response ...?
- Adrenaline
- Insulin
- Oxytocin
- Melatonin's
Explanation: Answer reason: The fight-or-flight response is mediated primarily by the sympathetic nervous system and the adrenal medulla, which rapidly releases adrenaline (epinephrine). Adrenaline increases heart rate, blood pressure, bronchodilation, and mobilizes glucose to prepare the body for acute stress. Insulin lowers blood glucose, oxytocin is involved in labor and bonding, and melatonin regulates sleep-wake cycles, so they are not the main acute stress hormones.
The hormone that confirms pregnancy in urine tests?
- LH
- FSH
- HCG
- Progesterone
Explanation: Answer reason: Urine pregnancy tests detect human chorionic gonadotropin (hCG), a hormone produced by the developing trophoblast/placenta shortly after implantation. hCG rises rapidly in early pregnancy and is filtered into urine, making it the standard marker for home and clinical urine tests. LH and FSH are pituitary gonadotropins related to ovulation and follicle development, not pregnancy confirmation. Progesterone supports the endometrium but is not the primary analyte used for urine pregnancy testing.
Which of the following is a sign of hypoglycemia?
- Increased thirst.
- Slow, deep breathing.
- Shakiness or tremors.
- Warm, dry skin.
Explanation: Answer reason: Hypoglycemia triggers an adrenergic (sympathetic) response, producing early warning symptoms such as shakiness, tremors, sweating, palpitations, and anxiety. Increased thirst and warm, dry skin are more consistent with hyperglycemia/dehydration. Slow, deep breathing suggests Kussmaul respirations seen with diabetic ketoacidosis rather than low blood glucose.
Blood Pressure in Human body is controlled by?
- Thymus
- Thyroid Gland
- Adrenal Gland
- Corpus Luteum
Explanation: Answer reason: Blood pressure is strongly regulated by adrenal hormones: aldosterone (adrenal cortex) increases sodium and water retention, raising blood volume and BP, and catecholamines like epinephrine/norepinephrine (adrenal medulla) increase heart rate and peripheral vasoconstriction, raising BP. The thyroid mainly influences basal metabolic rate and can affect cardiac output indirectly but is not the primary controller. The thymus is primarily immune-related, and the corpus luteum is a reproductive endocrine structure.
Insulin is secreted by?
- Liver
- Pancreas
- Kidney
- Adrenal
Explanation: Answer reason: Insulin is produced and secreted by the beta (β) cells in the islets of Langerhans of the pancreas. It is released primarily in response to elevated blood glucose to promote cellular glucose uptake and storage (glycogenesis and lipogenesis). The liver responds to insulin but does not secrete it, and kidneys/adrenals are not the source of insulin secretion.
Which hormone is known as the “hunger hormone”?
- Ghrelin
- Leptin
- Cortisol
- Oxytocin
Explanation: Answer reason: Ghrelin is primarily secreted by the stomach and rises before meals, stimulating appetite via hypothalamic pathways, which is why it is termed the “hunger hormone.” In contrast, leptin is produced by adipose tissue and promotes satiety (decreases appetite). Cortisol is a stress hormone that can affect metabolism and appetite but is not the primary physiologic hunger signal. Oxytocin is mainly involved in uterine contraction, milk ejection, and social bonding, not hunger regulation.
Which condition causes 'moon face' and 'buffalo hump'?
- Addison’s disease
- Hypothyroidism
- Cushing’s syndrome
- Hyperkalemia
Explanation: Answer reason: Moon face and a dorsocervical fat pad (“buffalo hump”) are classic signs of hypercortisolism, most commonly due to Cushing’s syndrome (endogenous cortisol excess or exogenous glucocorticoids). Cortisol causes central fat redistribution with relative thinning of extremities. Addison’s disease is adrenal insufficiency with weight loss and hyperpigmentation, not fat redistribution. Hypothyroidism can cause myxedematous facial puffiness but not a buffalo hump, and hyperkalemia is a lab abnormality rather than a syndrome producing these physical features.
Diabetes is related to?
- Liver
- Pancreas
- Heart
- Lungs
Explanation: Answer reason: Diabetes mellitus is primarily a disorder of insulin production and/or insulin action. Insulin is produced by beta cells in the pancreatic islets, and impaired secretion (type 1) or insulin resistance with relative deficiency (type 2) leads to chronic hyperglycemia. While the liver is important in glucose storage and release, the key organ directly implicated in diabetes pathophysiology is the pancreas.
The father of gland is-?
- Thyroid
- Pituitary
- Pancreas
- Adernal
Explanation: Answer reason: The pituitary gland is commonly called the "master gland" because it secretes trophic hormones (e.g., TSH, ACTH, LH/FSH) that regulate the activity of other endocrine glands such as the thyroid, adrenal cortex, and gonads. Although the hypothalamus controls pituitary function, the pituitary is the central endocrine regulator in classic teaching. Therefore, it is referred to as the "father" (master) gland among the options provided.
Which organ is both an endocrine and exocrine gland?
- Liver
- Stomach
- Pancreas
- Esophagus
Explanation: Answer reason: The pancreas has endocrine functions via the islets of Langerhans, which secrete hormones such as insulin and glucagon directly into the bloodstream. It also has exocrine functions via acinar cells that produce digestive enzymes (e.g., amylase, lipase, proteases) released into the duodenum through pancreatic ducts. The liver and stomach have important secretory roles, but they are not classically categorized as having both endocrine and exocrine gland functions in the way the pancreas does. The esophagus does not serve as an endocrine-exocrine gland.
Which hormone imbalance is most common in male infertility?
- Cortisol
- Testosterone
- FSH
- LH
Explanation: Answer reason: FSH is central to spermatogenesis because it stimulates Sertoli cells and supports sperm production. Abnormal FSH levels are commonly seen in male infertility evaluations: elevated FSH suggests primary testicular failure/damage, while low FSH suggests hypogonadotropic hypogonadism. Therefore, among the listed hormones, FSH imbalance is most directly and commonly associated with impaired fertility.
Which hormone increases during stress response?
- Insulin
- Cortisol
- Thyroxine
- Oxytocin
Explanation: Answer reason: During physiologic stress, the hypothalamic-pituitary-adrenal (HPA) axis is activated, increasing ACTH release and stimulating the adrenal cortex to secrete cortisol. Cortisol supports the stress response by increasing gluconeogenesis, mobilizing energy stores, and modulating inflammation and immune activity. Insulin typically decreases in acute stress due to counter-regulatory hormones, and thyroxine/oxytocin are not the primary hormones that rise for the acute stress response.
The "Dawn phenomenon" in diabetics refers to?
- Morning hypoglycemia
- Late-night hunger
- Morning rise in blood glucose
- Insulin overdose
Explanation: Answer reason: The dawn phenomenon is an early-morning increase in blood glucose due to circadian surges of counterregulatory hormones (e.g., cortisol, growth hormone, catecholamines) that increase hepatic glucose output and insulin resistance. It typically occurs in the pre-dawn hours and leads to elevated fasting glucose on waking. This differs from the Somogyi effect, which is morning hyperglycemia following nocturnal hypoglycemia from excess insulin. Therefore, the best answer is a morning rise in blood glucose.
Which hormone regulates circadian rhythm?
- Melatonin
- Cortisol
- Serotonin
- Dopamine
Explanation: Answer reason: Melatonin, secreted by the pineal gland, is the primary hormonal signal for regulating the sleep–wake cycle and synchronizing circadian rhythms to the light–dark cycle. Its secretion increases in darkness and is suppressed by light, helping promote sleep onset and nighttime physiology. Cortisol has a diurnal pattern but is not the main regulator of circadian timing. Serotonin and dopamine are neurotransmitters with roles in mood and arousal, not the principal circadian rhythm hormone.
Which hormone is responsible for milk ejection reflex?
- Oxytocin
- Prolactin
- Estrogen
- Progesterone
Explanation: Answer reason: Milk ejection (let-down) is mediated by oxytocin released from the posterior pituitary in response to nipple stimulation. Oxytocin causes contraction of myoepithelial cells around mammary alveoli and ducts, pushing milk toward the nipple. Prolactin, in contrast, primarily stimulates milk production (lactogenesis) by the mammary glands. Estrogen and progesterone support breast development and during pregnancy tend to inhibit full lactation until after delivery.
Oxytocin is ...?
- Medicine
- Hormone
Explanation: Answer reason: Oxytocin is a naturally occurring peptide hormone synthesized in the hypothalamus and released from the posterior pituitary. Physiologically it stimulates uterine contractions during labor and promotes milk ejection (let-down) during breastfeeding. Although it is also available as a medication (synthetic oxytocin), its biological classification is a hormone. Category reason: The item tests identification of oxytocin as a pituitary hormone and its role in human physiology, which is a foundational endocrine concept rather than a nursing-care decision.
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