Screenings and Immunizations Practice Test 5
Screenings and Immunizations NCLEX Practice Test
Screenings and Immunizations is a key topic within the NCLEX test plan, located under Health Promotion and Maintenance → Growth and Development → Screenings and Immunizations. This section reinforces evidence-based prevention schedules and follow-up for optimal health outcomes. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 5th part of the Screenings and Immunizations series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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Screenings and Immunizations Practice Test 5
How often is the influenza vaccine administered?
- Annually
- Biannually
- Quarterly
- Semiannually
Explanation: Answer reason: Because both viral antigenic drift and decreasing antibody levels reduce protection, a yearly dose provides the best ongoing prevention. Routine annual vaccination is recommended for most people aged 6 months and older, typically before the start of flu season. More frequent schedules (quarterly, semiannual, or biannual) are not standard and do not align with how the vaccine is updated and recommended.
A 17-year-old is at his annual appointment with a primary care provider. She has been taking Methylphenidate (Ritalin) for the last eight years for attention deficit hyperactivity disorder. Which of the following should the nurse be assessing for?
- Significant weight gain
- Fidgeting
- Trouble focusing
- Height and weight on the growth chart
Explanation: Answer reason: At annual health visits, the nurse should therefore monitor growth trends by plotting height and weight to detect deviations from expected percentiles. This assessment targets an important long-term adverse effect rather than ongoing ADHD symptoms. A common distractor is significant weight gain, which is not the typical growth-related concern with stimulant therapy.
The nurse has taught a pregnant client who has an elevated alpha-fetoprotein (AFP) level. Which of the following statements by the client would indicate a correct understanding of the teaching?
- My baby may have a hole in the spinal column.
- My baby may need surgery to repair the hard palate.
- My baby may have thick mucus that plugs the airways.
- My baby may have an enlarged liver and yellow skin after birth.
Explanation: Answer reason: An elevated maternal serum AFP is a screening finding most classically associated with open fetal neural tube defects due to fetal protein leaking into the amniotic fluid and maternal circulation. A defect such as spina bifida involves incomplete closure of the vertebral arches, which can be described as a “hole” in the spinal column. The other choices reflect conditions not primarily linked to increased AFP (e.g., cleft palate, cystic fibrosis, neonatal hepatitis/hemolysis), making them less consistent with this screening result. Therefore, this statement best demonstrates accurate understanding of what an elevated AFP may indicate and why follow-up diagnostic testing is needed.
MSAFP testing is most commonly performed during which gestational age range?
- 10 - 13 weeks
- 15 - 20 weeks
- 20 - 24 weeks
- 28 - 32 weeks
Explanation: Answer reason: The standard screening window is about 15–20 weeks’ gestation (often cited as 15–18 weeks as ideal), aligning with when abnormal elevations can be detected and followed up promptly. Testing earlier (first trimester) is not the typical timing for MSAFP and uses different screening approaches (e.g., PAPP-A, nuchal translucency). Testing much later reduces the usefulness for timely diagnostic confirmation and pregnancy management options.
A nurse is reviewing labs for a pregnant patient. If MSAFP is low, what does that indicate for the pregnancy?
- Diabetes
- Down syndrome
- Multiple fetuses present
- Neural tube defects
Explanation: Answer reason: The mechanism relates to altered fetoplacental production/transfer patterns that yield lower maternal circulating AFP compared with unaffected pregnancies. In contrast, neural tube defects and multiple gestation typically increase MSAFP due to greater fetal AFP exposure to maternal circulation. Abnormal screening results prompt confirmatory evaluation (e.g., detailed ultrasound and diagnostic testing) rather than serving as a definitive diagnosis.
The nurse is teaching the parents of a neonate about the Centers for Disease Control and Prevention (CDC) recommendations for hepatitis B vaccine. Which statement by the nurse would be the most accurate concerning these recommendations?
- It should be given to all neonates.
- It should be given to neonates exposed to hepatitis B only.
- It should be given to neonates showing symptoms of hepatitis B.
- It should be given to neonates whose mothers have human immunodeficiency virus.
Explanation: Answer reason: The CDC recommends that all newborns receive the hepatitis B vaccine shortly after birth, regardless of maternal infection status. This universal vaccination strategy helps prevent perinatal transmission and provides early protection. Options B and C are incorrect because vaccination is not limited to exposed or symptomatic infants. Option D is incorrect because the recommendation applies to all neonates, not only those born to mothers with HIV.
A man stepped on a piece of sharp glass while walking barefoot. He comes to the emergency department with a deep laceration on the bottom of his foot. Which question is the most important for the nurse to ask?
- “Was the glass dirty?”
- “Are you immune to tetanus?”
- “When did you have your last tetanus shot?”
- “How many diphtheria-pertussis-tetanus (DTaP) shots did you receive as a child?”
Explanation: Answer reason: Determining the timing of the last tetanus immunization is critical in wound management to assess the need for tetanus prophylaxis. This directly guides immediate clinical decision-making. Option A is less relevant than immunization status. Option B is vague and less actionable. Option D is not useful for acute decision-making in adults.
A 12-year-old child sustains a moderate burn injury. The mother reports that the child last received a tetanus injection when he was 5 years old. An appropriate nursing intervention would be to administer which immunization?
- 0.5 ml of tetanus toxoid I.M.
- 0.5 ml of tetanus toxoid I.V.
- 250 units of Hyper-Tet I.M.
- 250 units of Hyper-Tet I.V
Explanation: Answer reason: For a child with a wound and incomplete or outdated tetanus immunization (more than 5 years since last dose for a significant injury), a booster dose of tetanus toxoid is indicated. Intramuscular administration is the correct route.
The parent of a neonate asks the nurse what is the recommended age for beginning hepatitis B immunization. Which response is the most accurate?
- Birth
- 4 months
- 6 months
- 1 year
Explanation: Answer reason: The hepatitis B vaccine is recommended to be administered at birth, typically within the first 24 hours of life, regardless of maternal status. Early immunization helps prevent perinatal transmission and provides initial protection against hepatitis B infection. Subsequent doses are given according to the immunization schedule.
Which is the first vaccine typically given to a newborn at birth?
- Polio
- DTP
- BCG
- Tetanus
Explanation: Answer reason: BCG is commonly administered at birth in many immunization schedules to provide protection against severe forms of tuberculosis. Although some vaccines like hepatitis B may also be given at birth, among the provided options, BCG is the most appropriate first vaccine for a newborn.
Second dose of DPT is at—?
- 6 weeks
- 10 weeks
- 14 weeks
- 9 months
Explanation: Answer reason: In standard schedules using 6-10-14 week timing, the second dose is administered 4 weeks after the first. This interval supports adequate priming and boosting of immune response before later doses. Options like 14 weeks represent the third dose timing, while 9 months aligns more with vaccines such as measles-containing vaccines rather than DPT dose 2.
Which vaccine is given at birth?
- BCG, OPV-0, Hepatitis B
- Measles
- DPT
- JE vaccine
Explanation: Answer reason: Birth immunization schedules typically include vaccines aimed at preventing severe early-life infections and perinatal transmission. BCG is administered at birth in many national programs to reduce severe forms of tuberculosis in infants, and OPV-0 is given as a “zero dose” to prime mucosal immunity against polio. A hepatitis B birth dose is given to prevent early acquisition, especially from an infected mother, which carries a high risk of chronic infection. Measles, DPT, and JE are generally scheduled later in infancy because effective protection is timed around immune maturity and maternal antibody interference.
Which vaccine is given to pregnant women?
- Tetanus toxoid
- Measles
- BCG
- DPT
Explanation: Answer reason: Maternal tetanus immunization reduces neonatal tetanus by generating protective antibodies that cross the placenta. Measles (MMR) and BCG are live vaccines and are contraindicated during pregnancy in routine circumstances. DPT includes whole-cell pertussis formulations and is not the standard pregnancy recommendation; instead, pregnancy immunization focuses on tetanus-containing vaccines (commonly Tdap in many guidelines) for maternal and neonatal protection.
Which disease is NOT included in the Expanded Program on Immunization (EPI)?
- Measles
- Polio
- Malaria
- Tuberculosis
Explanation: Answer reason: The Expanded Program on Immunization focuses on vaccine-preventable diseases such as measles, polio, and tuberculosis (via BCG vaccine). Malaria is not part of the traditional EPI schedule because it is not routinely prevented through standard childhood immunization programs.
According to standard breast cancer screening guidelines, which recommendation is appropriate for asymptomatic women?
- Annual mammogram screening beginning at age 40
- Physical breast exams and biopsy screening between ages 40 and 50
- Monthly breast self-examinations for all women age 16 and older
- Biannual mammogram screening for all women over 40
Explanation: Answer reason: Traditional screening guidelines recommend annual mammography starting at age 40 for early detection of breast cancer in asymptomatic women. Other options either include outdated practices or incorrect screening intervals.
A public health nurse identifies increased lead toxicity among children in a community and implements a screening program. This action is an example of which ethical principle?
- Social justice
- Policy resources
- Autonomy
- Moral justification
Explanation: Answer reason: The nurse is implementing a community-wide screening program, which is a form of secondary prevention aimed at early detection of disease. This action reflects social justice by promoting equitable health protection for at-risk populations through accessible screening services.
A patient is in her first trimester of her second pregnancy. The patient's first child was born with a trisomy 21 defect. The patient is requesting testing to determine whether the current fetus has the same defect. Which initial testing does the nurse expect the HCP to prescribe?
- Magnetic resonance imaging
- Fetal ultrasound
- Chorionic villa sampling
- Amniocentesis
Explanation: Answer reason: In the first trimester, chorionic villus sampling can obtain placental tissue early (about 10–13 weeks), making it the appropriate initial diagnostic test when a high-risk history exists. Amniocentesis is also diagnostic but is typically performed later in the second trimester, so it is not the earliest option for this gestational age. Ultrasound and MRI can identify some anatomic markers but cannot confirm fetal aneuploidy as a standalone diagnostic test.
Which organization provides polio vaccines globally?
- WHO
- UNICEF
- Red Cross
- UNESCO
Explanation: Answer reason: UNICEF is the world’s largest single buyer of vaccines and is a primary channel for procuring and delivering polio vaccines for routine immunization and eradication efforts. WHO provides technical guidance, surveillance standards, and coordination, but it is not the main global procurement/supply organization for vaccine commodities. Red Cross and UNESCO have important humanitarian/education roles, yet they are not the core global vaccine-supply mechanism for polio.
EPI challenges include—?
- Low coverage in remote areas
- Vaccine hesitancy
- Cold chain problems
- All of the above
Explanation: Answer reason: Remote geographic areas commonly have reduced service reach and fewer opportunities for timely vaccination, lowering coverage. Community acceptance barriers, including hesitancy and misinformation, directly reduce uptake even when services are available. Cold chain failures compromise vaccine potency, producing ineffective immunization and avoidable outbreaks, so each listed factor is a recognized EPI challenge; therefore the combined choice is best.
EPI is monitored by—?
- Pediatricians
- Public health authorities
- Mothers only
- Teachers
Explanation: Answer reason: Public health agencies coordinate these functions through standardized schedules, registries, and disease notification systems, allowing detection of gaps in vaccination and rapid response to vaccine-preventable diseases. Individual clinicians (e.g., pediatricians) administer vaccines and counsel families, but they do not oversee program-wide monitoring and performance metrics. Non-clinical groups such as teachers or “mothers only” cannot provide the centralized epidemiologic tracking and accountability needed for an expanded immunization program.
Rotavirus vaccine schedule is—?
- Birth, 6 weeks, 10 weeks
- 6, 10, 14 weeks
- 9 months only
- 12 months only
Explanation: Answer reason: Routine childhood immunization schedules time vaccines to protect infants early in life when vulnerability to severe gastroenteritis is highest. Rotavirus vaccine is administered in early infancy as a multi-dose series with doses spaced about 4 weeks apart, aligning with the standard infant visit timeline. This option matches the typical early-week schedule used in many national programs and avoids late single-dose timing, which would miss the required series and delay protection. The other choices either incorrectly include a birth dose or place vaccination at 9–12 months, which is not how rotavirus immunization is scheduled in infancy.
At what age should an infant receive their first MMR vaccine?
- At birth
- 2 months
- 6 months
- 12 months
Explanation: Answer reason: The first dose of the measles, mumps, and rubella (MMR) vaccine is routinely administered at 12–15 months of age. Earlier administration is not standard unless in special high-risk situations.
A nurse is providing anticipatory guidance to a parent of a 1-month-old infant. The nurse should include that it is recommended to start this series of which of the following immunizations first?
- Varicella
- Measles, mumps, rubella
- Inactivated poliovirus
- Hepatitis A
Explanation: Answer reason: The inactivated poliovirus (IPV) vaccine series begins at 2 months of age, making it the earliest among the listed options. MMR and varicella are given at 12 months, and hepatitis A typically starts at 12–23 months. Anticipatory guidance includes upcoming immunizations in the first months of life.
According to WHO immunization guidelines, which vaccine is given at 9 months of age?
- MMR
- OPV
- Measles vaccine
- DPT
Explanation: Answer reason: This timing aims to provide protection as maternally derived antibodies wane and before peak community exposure. OPV and DPT are typically started earlier in infancy with multiple primary-series doses, making them less specifically tied to the 9-month milestone. MMR is often scheduled later (e.g., around 12–15 months) in many schedules, whereas a single measles dose at 9 months is a classic standard in several public health programs.
Which of the following groups is at the lowest risk for iron deficiency anemia?
- Toddlers
- School-age children
- Adolescents
- Pregnant women
Explanation: Answer reason: Toddlers are high risk due to rapid growth and often excessive cow’s milk intake with low dietary iron. Adolescents—especially those with menstrual blood loss and growth spurts—are also a key at-risk group, and pregnant women have markedly increased iron requirements. Compared with these groups, generally healthy school-age children have a lower baseline risk and are not typically the primary target group for focused community monitoring.
The nurse administers a PPD test to a co-worker. The nurse will read the test at?
- 12-24 hours.
- 24-48 hours.
- 48-72 hours.
- 72-96 hours.
Explanation: Answer reason: PPD (Mantoux) interpretation depends on a delayed-type (type IV) hypersensitivity response that peaks after 2–3 days. Reading it earlier can miss developing induration and yield a false-negative result, while reading too late may allow the induration to begin resolving and underestimate the reaction. The nurse must measure induration (not erythema) within the recommended window for accurate screening. This timing is a standard occupational health screening practice for tuberculosis exposure surveillance.
A parent has a question about the Rotavirus vaccine and when it is administered. As the nurse you know that ______ doses are given, and the last dose is given at ______?
- 2; 6 months
- 3; 4 months
- 4; 4-6 years
- 3; 6 months
Explanation: Answer reason: Rotavirus vaccination is an oral infant immunization series that must be completed early in life due to age-related safety and scheduling limits. The full series can be 2-dose or 3-dose depending on product, but when asked as a single best generalized schedule, the common series is given at 2, 4, and 6 months with completion by 6 months. Options that end at 4 months are incomplete for the 3-dose product schedule, and an option extending to 4–6 years confuses it with other childhood boosters (e.g., DTaP/MMR/Varicella). Finishing the series by 6 months aligns with routine immunization timing and the need to complete before upper age cutoffs for later doses.
During Rubella vaccination first priority is given to?
- All children
- 15-39 years old female
- Adolescent girl
- Pregnant woman
Explanation: Answer reason: Vaccinating girls in adolescence captures those nearing reproductive age before exposure through pregnancy and allows time to avoid conception shortly after vaccination (live attenuated vaccine). Pregnant individuals should not receive rubella vaccine because live vaccines are contraindicated in pregnancy. While broad childhood immunization is important, the question asks “first priority,” which most directly targets future mothers before childbearing begins.
At what age should blood test screening for lead poisoning in a low-risk child begin?
- 6 months
- 24 months
- 12 months
- 18 months
Explanation: Answer reason: Lead exposure risk increases as infants become mobile and engage in frequent hand-to-mouth behavior, making the first routine blood lead screening at 12 months appropriate even in low-risk settings. A later start delays identification during a critical brain-development window. Earlier universal testing at 6 months is not standard because exposures typically rise after increased crawling/walking and environmental exploration, though targeted testing may be done sooner if risk factors are present.
If an infant has not been immunized with BCG at birth or with DPT-I than-?
- These should be avoided
- These should be given at the age of five years
- These can be given any time upto the age of one year
- Both of BCG and DPT-I should be given with DPT-II and DPT-III
Explanation: Answer reason: BCG is ideally given at birth but can still be administered later in infancy, and primary DPT series should be initiated promptly with appropriate spacing between doses. Delaying until 5 years increases the period of susceptibility to vaccine-preventable diseases in early childhood. Co-administering the first DPT dose only at the time of later doses is not the recommended approach; instead, the series should be started and continued on a catch-up schedule.
Which diagnostic test would be the most important to have for a primigravid client in the second trimester of her pregnancy?
- Culdocentesis.
- Chorionic villus sampling.
- Ultrasound testing.
- Α-fetoprotein (AFP) testing.
Explanation: Answer reason: Second-trimester prenatal care emphasizes screening for fetal structural anomalies and aneuploidy risk using maternal serum testing. AFP (typically drawn around 15–20 weeks) helps screen for open neural tube defects and, when part of a multiple-marker screen, contributes to risk assessment for chromosomal abnormalities. Chorionic villus sampling is performed earlier (first trimester) and is not the routine second-trimester screen. Culdocentesis is not a standard obstetric screening test and is generally unrelated to routine prenatal second-trimester diagnostics.
First vaccine given at birth is?
- DPT
- OPV
- BCG
- Measles
Explanation: Answer reason: BCG is commonly administered at birth (or as soon as possible afterward) to reduce the risk of severe forms of tuberculosis such as miliary TB and TB meningitis. In contrast, DPT is typically started later in infancy as a primary series rather than at birth, and measles vaccine is deferred because maternal antibodies reduce vaccine effectiveness early on. OPV timing varies by program, but the classic single best “at birth” vaccine tested in many nursing exams is BCG.
The parent of an 11-month-old child calls the pediatric outpatient clinic and tells the nurse that the child was exposed to measles 2 days ago during a family trip to a theme park. What is the best response by the nurse?
- Bring the baby into the clinic for the measles, mumps, rubella (MMR) vaccine
- Check the baby's temperature twice a day
- Do not allow the child to have contact with other children
- Does your child have a fever or rash?
Explanation: Answer reason: The exposure occurred 2 days ago, placing the child within that window, so prompt vaccination is the most effective immediate nursing guidance. Simply monitoring temperature or asking about symptoms does not address prevention and may delay a time-sensitive intervention. Avoiding contact with other children is important if illness develops, but it is not the primary best initial response when effective post-exposure prophylaxis is available.
A 50-year-old male went to his family practitioner for his annual wellness exam. Since the patient was 50, the practitioner ordered the patient to have a double-contrast barium enema done. What type of screening is the practitioner ordering the patient to have done?
- Prostate screening
- Fasting lipid profile
- Colorectal screening
- Mammogram
Explanation: Answer reason: A double-contrast barium enema is an imaging test used to evaluate the colon and rectum for masses, polyps, or other abnormalities and has historically been used for colorectal cancer screening. At age 50 (traditional starting age in many screening guidelines), average-risk adults are recommended to begin colorectal cancer screening, making this test aligned with that goal. Prostate screening would involve PSA testing and/or digital rectal exam rather than a barium enema, and a mammogram is a breast cancer screening test, not applicable here.
The parents of a 9-month-old bring the infant to the clinic for a regular checkup. The infant has received no immunizations. Which vaccine order would the nurse question?
- Diphtheria, tetanus, and acellular pertussis (DTaP).
- Haemophilus influenzae type B (Hib).
- Measles, mumps, and rubella (MMR).
- Hepatitis B (Hep B).
Explanation: Answer reason: Routine immunization schedules time specific vaccines to ages when they are both safe and most effective. MMR is a live attenuated vaccine that is typically first given at 12–15 months, so ordering it at 9 months (without a special indication like international travel/outbreak) should be questioned. In contrast, DTaP, Hib, and Hep B are started in early infancy and are appropriate to begin as catch-up vaccines at 9 months. The nurse’s role is to verify timing/indications and prevent administration outside recommended age windows.
Polio is prevented by which vaccine?
- BCG
- OPV
- MMR
- DPT
Explanation: Answer reason: The oral polio vaccine provides protective immunity and, because it is live-attenuated, also promotes intestinal (mucosal) immunity that helps interrupt fecal–oral transmission. The other listed vaccines target different pathogens (e.g., BCG for tuberculosis, MMR for measles/mumps/rubella, DPT for diphtheria/pertussis/tetanus) and therefore would not prevent polio. Selecting the vaccine that specifically contains poliovirus antigen is the key principle in matching vaccine to disease prevention.
An elderly client asks the nurse how often he will need to receive immunizations against pneumonia. The nurse should tell the client that she will need an immunization against pneumonia?
- Every year
- Every 2 years
- Every 5 years
- Every 10 years
Explanation: Answer reason: A 5-year interval aligns with the commonly tested guidance for repeat pneumococcal immunization in certain older/high-risk populations when revaccination is indicated. Annual schedules are associated with influenza, making that a common distractor. Ten years is more consistent with tetanus/diphtheria boosters, not pneumococcal protection.
A primigravid adolescent client at approximately 15 weeks' gestation who is visiting the prenatal clinic with her mother is to undergo alpha-fetoprotein (AFP) screening. When developing the teaching plan for this client, the nurse should include which of the following?
- Ultrasonography usually accompanies AFP testing.
- Results are usually very accurate until 20 weeks' gestation.
- A clean-catch midstream urine specimen is needed.
- Increased levels of AFP are associated with neural tube defects.
Explanation: Answer reason: Maternal serum AFP is a screening test in the second trimester where elevated values reflect increased fetal protein leakage into amniotic fluid and maternal circulation, classically seen with open neural tube defects. Teaching should emphasize what an abnormal result may indicate so the client understands the purpose and implications of the screening. The urine specimen option is incorrect because AFP screening is performed on maternal blood, not urine. While ultrasound may be used after an abnormal screen to help confirm gestational age or evaluate fetal anatomy, it does not “usually accompany” routine AFP screening.
The nurse is performing community health screenings. A client tells the nurse that they smoke two packs a day of cigarettes and have smoked for six years. The nurse should document this finding as how many pack years?
- 3.5 pack years
- 3 pack years
- 12 pack years
- 6 pack years
Explanation: Answer reason: Pack-years quantify lifetime tobacco exposure using the formula packs per day multiplied by years smoked. The client reports 2 packs/day for 6 years, so the cumulative exposure is 2 × 6 = 12 pack-years. This standardized documentation supports risk stratification for conditions like COPD, cardiovascular disease, and lung cancer during community screening. Other options reflect incorrect multiplication or misapplication of the pack-year definition.
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