Gastrointestinal System Practice Test 2
Gastrointestinal System NCLEX Practice Test
Gastrointestinal System is a key topic within the NCLEX test plan, located under Nursing Science → Clinical Foundations → Gastrointestinal System. This section explains digestion, elimination, and nursing care for GI pathologies and nutrition issues. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 2nd part of the Gastrointestinal System series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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In the Gastrointestinal System Study Cards section, shared by real NCLEX candidates, you’ll find concise summaries and high-yield insights related to the most tested concepts. It’s a perfect space to reinforce challenging topics and sharpen your recall through quick, focused repetitions. Short, powerful, and repeatable!
Gastrointestinal System Practice Test 2
The following digestive enzyme is present in gastric juice?
- Pepsin
- Trypsin
- Chymotrypsin
- Peptidases
Explanation: Answer reason: Gastric juice contains pepsin (from pepsinogen) for protein digestion; trypsin and chymotrypsin are pancreatic enzymes and peptidases act mainly in the intestine.
Which of the following is the most common type of Hirschsprung's disease?
- Congenital
- Acquired
- Vascular
- Non-Vascular
Explanation: Answer reason: Hirschsprung disease is a congenital absence of enteric ganglion cells in the distal bowel, making the condition predominantly congenital rather than acquired.
Which of the following passages best describes esophageal atresia?
- A soft trachea causing respiratory difficulty in childhood.
- An incomplete passageway from the mouth to the stomach, present at birth.
- A passageway joining the trachea and the esophagus, present at birth.
- When stomach contents return to the esophagus.
Explanation: Answer reason: Esophageal atresia is a congenital interruption of the esophagus, leaving a blind upper segment and no continuous passage to the stomach. Option C describes a tracheoesophageal fistula; A is tracheomalacia; D is GERD.
In Hirschsprung's disease, the aganglionic segment most commonly occurs in?
- Rectum
- Ileum
- Ascending colon
- Caecum
Explanation: Answer reason: Hirschsprung disease is congenital aganglionosis of the distal bowel, most commonly the rectosigmoid region beginning at the rectum; hence the aganglionic segment most commonly involves the rectum.
Which part of the body is affected by typhoid?
- Lungs
- Intestines
- Liver
- Pancreas
Explanation: Answer reason: Typhoid fever (Salmonella typhi) primarily targets the intestinal lymphoid tissue, especially Peyer’s patches of the ileum, causing enteric symptoms and complications.
Screening test for Hirschsprung's disease?
- Suction biopsy
- Electromanometry
- Rectal biopsy
- Invertogram
Explanation: Answer reason: Anorectal manometry (electromanometry) is used as the screening test for Hirschsprung disease by demonstrating absence of the rectoanal inhibitory reflex; the definitive test is rectal suction biopsy.
The confirmatory diagnostic test for Hirschsprung's disease is ______?
- Invertogram
- Rectal biopsy
- Abduction CT
- Fiber-optic nasoenteric tube
Explanation: Answer reason: The definitive diagnosis for Hirschsprung disease is made by rectal suction biopsy showing absence of ganglion cells. Invertogram is for anorectal malformations; CT and nasoenteric tube are not confirmatory tests for Hirschsprung.
A newborn has dribbling after feeds. He has respiratory distress and froths at the mouth. Diagnosis?
- Tracheoesophageal fistula
- Tetralogy of Fallot
- Respiratory distress syndrome
- None of the above
Explanation: Answer reason: Newborn with drooling/frothy saliva and respiratory distress after feeds is classic for esophageal atresia with tracheoesophageal fistula causing aspiration and inability to handle secretions.
A patient with cystic fibrosis is diagnosed with pancreatic insufficiency. As the nurse you know that the patient will not be lacking?
- Amylase
- Pepsin
- Protease
- Lipase
Explanation: Answer reason: Cystic fibrosis causes exocrine pancreatic insufficiency, reducing pancreatic enzymes amylase, lipase, and proteases. Pepsin is a gastric enzyme produced by the stomach, so it is not lacking due to pancreatic insufficiency.
The part of digestive system not found in abdominal cavity is-?
- Liver
- Small intestine
- Bile ducts
- Rectum
Explanation: Answer reason: The rectum lies in the pelvic cavity, whereas the liver, small intestine, and bile ducts are located within the abdominal cavity.
Double bubble sign in the X-ray suggestive of _________?
- Double atresia
- Intestinal obstruction
- Aganglionic megacolon
- Trachea esophageal fistula
Explanation: Answer reason: The classic 'double bubble' on abdominal X-ray represents gas in the stomach and proximal duodenum with absent distal gas, which is characteristic of duodenal atresia (listed here as 'Double atresia'). Other options do not produce this specific sign.
Which of the following statement about Hirschsprung disease is are true?
- A B C
- A D E
- A B D E
- A C D E
Explanation: Answer reason: Hirschsprung disease is congenital aganglionosis of the distal bowel with absence of ganglion cells in Auerbach (and Meissner) plexuses (A). It has increased association with Down syndrome (B) and can lead to Hirschsprung-associated enterocolitis (D). Long-segment/total colonic disease may extend into the small intestine (E). It is more common in males, not girls, so (C) is false.
False statement regarding Hirschsprungs disease?
- Aganglionosis mostly involved rectum and sigmoid colon.
- Non passage of meconium in first 24 hours is a cardinal feature
- Diagnosis is established by suction rectal biopsy
- No passage of stool after per rectal examination.
Explanation: Answer reason: In Hirschsprung disease, recto‑sigmoid aganglionosis is common and diagnosis is by suction rectal biopsy; delayed passage of meconium is typical. On digital rectal exam there is usually explosive passage of stool (squirt sign), not absence—making option D false.
“3C’s” (Coughing and choking during feeding and unexplained cyanosis) is associated with....?
- Tracheoesophageal fistula
- Cleft lip and cleft palate
- Pyloric stenosis
- GERD
Explanation: Answer reason: The classic triad of coughing, choking during feeds, and cyanosis indicates tracheoesophageal fistula/esophageal atresia due to aspiration and inability of feeds to pass into the stomach.
A Clinical condition in which "narrowing of the outlet of the stomach so that food cannot pass easily from it into the duodenum"?
- Intussuscection
- Hirschsprung disease
- Pyloric Stenosis
- GERD
Explanation: Answer reason: Pyloric stenosis is narrowing of the pyloric sphincter at the gastric outlet, preventing gastric contents from passing easily into the duodenum. Intussusception is telescoping of bowel, Hirschsprung disease is aganglionic megacolon, and GERD is reflux.
Hirschprungs disease has been seen is association with the following except?
- Microcephaly
- Mental Retardation
- Autism
- Cleft lip
Explanation: Answer reason: Hirschsprung disease is often syndromic and associated with conditions such as Down syndrome and Mowat-Wilson syndrome, which include microcephaly and intellectual disability. Autism is not a recognized association.
Nurse was going through the file of a child who is admitted with hypertrophic pyloric stenosis. All among the following except one can be seen in the file?
- Olive like mass
- Radiating pain towards left shoulder
- String sign in the X-Ray
- Projectile Vomiting
Explanation: Answer reason: Hypertrophic pyloric stenosis presents with an olive-like epigastric mass, projectile non-bilious vomiting, and a string sign on imaging. Radiating pain to the left shoulder is not a feature of pyloric stenosis.
Vomiting caused by Pyloric stenosis generally not bile stained because?
- Bile duct is also obstructed
- The obstruction of the cardiac sphincter prevent bile from entering the oesophagus.
- The sphincter of the bile duct is connected to the hyper trophied
- Obstruction is about the opening of the common bile duct
Explanation: Answer reason: In pyloric stenosis the obstruction is proximal to the duodenal papilla where bile enters; therefore vomitus is non‑bilious.
Gasless abdomen on X-Ray is seen in what type of trachea esophageal fistula?
- Isolated TEF
- EA with proximal TEF
- EA with distal TEF
- EA with double TEF
Explanation: Answer reason: A gasless abdomen occurs when there is no connection between the trachea and the distal esophagus, so air cannot reach the stomach—seen with esophageal atresia with a proximal TEF. Distal or double TEF provide a route for air to the stomach, producing gas.
In Hirschsprungs disease, in colon where Aganglionic segment is located?
- Distal to dilated segment of colon
- Proximal to dilated segment of colon
- At the dilated segment of colon
- Entire colon
Explanation: Answer reason: In Hirschsprung disease the distal colon and rectum lack enteric ganglion cells; functional obstruction at this distal aganglionic segment causes proximal dilation (megacolon).
Surgery for Hirschprungs disease all except?
- Swenson procedure
- Altemeier’s procedure
- Duhamel procedure
- Soave procedure
Explanation: Answer reason: Swenson, Duhamel, and Soave are classic pull-through operations for Hirschsprung disease. Altemeier’s procedure is a perineal rectosigmoidectomy for rectal prolapse, not for Hirschsprung disease.
All of following are clinical feature of a congenital hypertrophied pyloric stenosis in children are except?
- Dehydration
- Nonbilirus vomiting
- Visible peristalsis
- Regurgitation
Explanation: Answer reason: Hypertrophic pyloric stenosis presents with nonbilious projectile vomiting, visible gastric peristalsis, and dehydration. Simple regurgitation is typical of GERD, not pyloric stenosis, so it is the exception.
Which one of the following life threatening congenital anomalies in the newborn presents with polyhydramnios, aspiration pneumonia, excessive salivation and difficulty in passing a nasogastric tube?
- Gastroschisis
- Tracheo-esophageal fistula
- Diphragmatic hernia
- Choanal atresia
Explanation: Answer reason: Esophageal atresia with tracheoesophageal fistula causes inability to swallow amniotic fluid leading to polyhydramnios; newborn has excessive drooling, coughing/aspiration, and an NG/OG tube cannot be passed into the stomach.
Most usual biochemical abnormality in congenital hypertropic pyloric stenosis?
- Hypokalemia metabolic alkalosis
- Hyperkalemia metabolic acidosis
- Hypokalemia Metabolic acidosis
- Hyperkalemia metabolic alkalosis
Explanation: Answer reason: Projectile vomiting of gastric HCl causes metabolic alkalosis; volume depletion activates RAAS leading to renal potassium loss and hypokalemia.
All of the following are characteristics of Hirschsprung's disease except?
- Explosive diarrhea
- Abdominal distension
- Bile-stained vomiting
- Telescoping of intestine
Explanation: Answer reason: Telescoping of intestine refers to intussusception, not Hirschsprung disease. Hirschsprung presents with abdominal distension and may have bile-stained vomiting and explosive stools.
Which explanation is most accurate when the nurse teaches a client about intussusception of the bowel?
- Kinking of the bowel onto itself
- A band of connective tissue compressing the bowel
- Telescoping of a proximal loop of bowel into a distal loop
- A protrusion of an organ or part of an organ through the wall that contains it
Explanation: Answer reason: Intussusception is defined as telescoping of one segment of intestine into an adjacent distal segment. Other options describe volvulus, adhesions, and hernia.
In a children, herniation of the abdominal organ through a wide open umbilicus is termed as-?
- Gastroschisis
- Exomphalos
- Hirshsprung’s disease
- Hiatal hernia
Explanation: Answer reason: Exomphalos (omphalocele) is herniation of abdominal viscera through the umbilical ring; gastroschisis occurs lateral to the umbilicus, Hirschsprung’s is aganglionosis, and hiatal hernia involves the diaphragm.
Appendix is a part of?
- Liver
- Stomach
- Small intestine
- Large intestine
Explanation: Answer reason: The vermiform appendix is attached to the cecum, which is part of the large intestine.
Pepsin is the example of .........?
- Amylase
- Nuclease
- Protease
- None of these
Explanation: Answer reason: Pepsin is a digestive enzyme in the stomach that breaks down proteins; it is a protease.
A tubular structure that joins the pharynx to the stomach is?
- Trachea
- Larynx
- Cricoid cartilage
- Esophagus
- Crania
Explanation: Answer reason: The esophagus is the muscular tube that connects the pharynx to the stomach; trachea and larynx are parts of the airway, cricoid cartilage is part of the larynx, and crania refers to the skull.
A tubular structure that joins the pharynx to the stomach is?
- Trachea
- Larynx
- Cricoids cartilage
- Esophagus
Explanation: Answer reason: The esophagus is the muscular tube that connects the pharynx to the stomach; trachea and larynx are respiratory structures, and cricoid cartilage is a laryngeal cartilage.
The dome-shaped full of gas part of the stomach called?
- Fundus
- Pylorus
- Antrum
- Body of the stomach
- Cardiac orifice
Explanation: Answer reason: The gas-filled dome at the superior portion of the stomach is the fundus.
The duct which connects the neck of gall bladder to the common hepatic duct is called?
- Hepatic duct
- Cystic duct
- Bile duct
- Bancreatic duct.
Explanation: Answer reason: The cystic duct connects the neck of the gallbladder to the common hepatic duct; together they form the common bile duct. The hepatic duct drains the liver, the bile duct is the resulting common bile duct, and the pancreatic duct is unrelated.
Dilated part of the alimentary canal between the esophagus and the small intestine called?
- Esophagus
- Colon
- Stomach
- Rectum
Explanation: Answer reason: The stomach is the dilated sac of the GI tract located between the esophagus and the duodenum (first part of the small intestine).
A tubular structure that joins the pharynx to the stomach is?
- Crania
- Cricoid cartilage
- Esophagus
- Trachea
- Larynx
Explanation: Answer reason: The esophagus is the muscular tube that connects the pharynx to the stomach. The trachea leads to the lungs, the larynx and cricoid cartilage are parts of the airway, and the crania refers to the skull.
Dilated part of the alimentary canal between the esophagus and small intestine called?
- Colon
- Esophagus
- Jejunum
- Rectum
- Stomach
Explanation: Answer reason: The stomach is the dilated muscular sac situated between the esophagus and the small intestine. Colon and rectum are parts of the large intestine; jejunum is a segment of the small intestine; esophagus is proximal to the stomach.
The most tubular part of stomach is?
- Antrum
- Body of stomach
- Cardiac orifice
- Fundus
- Pylorus
Explanation: Answer reason: The pylorus (pyloric canal) is the narrow tubular segment of the stomach leading into the duodenum; other regions are more sac-like.
The dome shaped full of gas part of stomach is called?
- Antrum
- Body of stomach
- Cardiac orifice
- Fundus
- Pylorus
Explanation: Answer reason: The fundus is the dome-shaped superior portion of the stomach under the diaphragm that commonly contains a gas bubble. The antrum and pylorus are distal parts, the body is central, and the cardiac orifice is an opening.
The greater curvature of the stomach provides space for the attachment of __________?
- Greater Omentum
- Inferior Mesentery
- Lesser Omentum
- Superior Mesentery
- Visceral Peritoneum
Explanation: Answer reason: The greater curvature is the attachment site for the greater omentum, while the lesser curvature attaches the lesser omentum; mesenteries are for intestines and visceral peritoneum simply covers organs.
What does the liver store?
- Vitamins
- Blood cells
- Carbs
Explanation: Answer reason: The liver stores several vitamins (notably A, D, K, and B12) and minerals; it does not store blood cells. While it stores glucose as glycogen, the option given is broadly 'carbs,' making vitamins the best single answer.
Which among the following is the longest?
- Stomach
- Esophagus
- Small intestine
- Large intestine
Explanation: Answer reason: The small intestine is the longest GI segment (~6–7 meters), longer than the large intestine (~1.5 m), esophagus (~25 cm), or stomach.
Insufficient intrinsic factor commonly occurs in elderly adults. It causes inadequate absorption of?
- Cobalamin
- Riboflavin
- Pyridoxin
- Niacin
Explanation: Answer reason: Intrinsic factor from gastric parietal cells is required for vitamin B12 (cobalamin) absorption in the terminal ileum; its deficiency leads to B12 malabsorption.
What is inflammation of the appendix called?
- Colitis
- Gastritis
- Appendicitis
- Hepatitis
Explanation: Answer reason: The suffix -itis means inflammation; inflammation of the appendix is called appendicitis.
What is the appendix?
- Digestive gland
- Vestigial organ
- Blood vessel
- Bone
Explanation: Answer reason: The appendix is a narrow, wormlike structure attached to the cecum and is considered a vestigial organ, not a gland, vessel, or bone.
Ileum is located in which intestine?
- Small intestine
- Large intestine
- Liver
- Rectum
Explanation: Answer reason: The ileum is the distal segment of the small intestine (following the jejunum), not part of the large intestine, liver, or rectum.
Digestion in small intestine occurs in ..........?
- Acidic medium
- Alkaline medium
- Neutral medium
- Isotonic solution
Explanation: Answer reason: Pancreatic bicarbonate and bile alkalinize the duodenal contents (pH ~7.5–8.5), and digestive enzymes of the small intestine function optimally in an alkaline medium.
What is phototherapy used for?
- Dehydration
- Malaria
- Kidney failure
- Neonatal jaundice
Explanation: Answer reason: Phototherapy converts unconjugated bilirubin into water‑soluble isomers for excretion, treating neonatal hyperbilirubinemia (jaundice).
Jaundice occurs due to accumulation of?
- Urea
- Bilirubin
- Creatinine
- Ketone bodies
Explanation: Answer reason: Jaundice is yellow discoloration from elevated bilirubin levels (hyperbilirubinemia). Urea and creatinine relate to renal function; ketone bodies to ketoacidosis.
The bile is produced through?
- Stomach
- Liver
- Kidney
Explanation: Answer reason: Bile is synthesized by hepatocytes in the liver and stored in the gallbladder.
Most common site of carcinoma pancreas is-?
- Head
- Body
- Tail
- None of the above
Explanation: Answer reason: Pancreatic adenocarcinoma most commonly arises in the head of the pancreas (about two-thirds of cases).
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