Endocrine System Practice Test 18
Endocrine System NCLEX Practice Test
Endocrine System is a key topic within the NCLEX test plan, located under Nursing Science → Clinical Foundations → Endocrine System. This section reviews hormonal regulation and nursing priorities in metabolic and endocrine disorders. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 18th part of the Endocrine System series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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Endocrine System Practice Test 18
Which metabolic alteration characteristic might be associated with growth hormone deficiency?
- Galactosemia
- Homocystinuria
- Hyperglycemia
- Hypoglycemia
Explanation: Answer reason: When growth hormone is deficient, especially in infants and young children, decreased gluconeogenesis and reduced mobilization of alternative fuels can predispose to low serum glucose. This makes episodes of fasting intolerance and low blood sugar a recognized metabolic association of growth hormone deficiency. In contrast, hyperglycemia is more consistent with excess counter-regulatory hormones or diabetes rather than growth hormone deficiency.
Thyroid radioactive iodine uptake and scan is usually performed on clients with an established diagnosis of?
- Hypothyroidism.
- Myxedema.
- Thyroid storm.
- Thyrotoxicosis.
Explanation: Answer reason: Radioactive iodine uptake (RAIU) and scanning evaluate thyroid function and etiology by measuring how much iodine the gland traps and how it is distributed. This test is most useful in hyperthyroid states to distinguish causes such as Graves disease (diffusely increased uptake) versus thyroiditis or exogenous thyroid hormone use (low uptake). In severe acute presentations like thyroid storm, diagnosis and treatment are clinical and emergent, so imaging/uptake testing is not typically performed at that time. In hypothyroidism or myxedema, RAIU is generally not the usual diagnostic test because thyroid function tests and antibody studies are more direct.
The nurse cares for a client with Addison’s disease. Which should the nurse expect to observe when assessing the client?
- Anorexic appearance.
- Tachycardia.
- Edema.
- Dry skin.
Explanation: Answer reason: Primary adrenal insufficiency causes deficient cortisol and aldosterone, leading to chronic fatigue, weight loss, anorexia, and GI complaints (e.g., nausea). Decreased cortisol reduces appetite and contributes to unintended weight loss, making an undernourished or anorexic appearance a classic assessment finding. Edema is less likely because low aldosterone promotes sodium and water loss rather than retention. Tachycardia can occur secondary to hypovolemia or hypotension but is less characteristic as a defining expected baseline finding than weight loss/anorexia.
The nurse suspects a client of having diabetic ketoacidosis. Which blood glucose value would be observed with this condition?
- 50 mg/dl
- 90 mg/dl
- 150 mg/dl
- 300 mg/dl
Explanation: Answer reason: Blood glucose is typically significantly elevated (commonly >250 mg/dL) due to increased hepatic glucose output and reduced peripheral uptake. A value of 300 mg/dl fits this expected hyperglycemic range in DKA. By contrast, 50 and 90 mg/dl represent hypoglycemia/normal glucose and would not support DKA, while 150 mg/dl is only mildly elevated and less consistent with classic DKA.
The nurse is caring for a client with an adrenal medulla tumor. Which of the following symptoms would the nurse expect to assess?
- Carpopedal spasm
- Hyperglycemia
- Hypertension
- “Moon face”
Explanation: Answer reason: This drives peripheral vasoconstriction and increased cardiac output, making elevated blood pressure a hallmark expected finding. Hyperglycemia can also occur from catecholamine-induced glycogenolysis and insulin inhibition, but it is less characteristic as the primary presenting symptom than high blood pressure. Carpopedal spasm points more toward hypocalcemia, and “moon face” is typical of cortisol excess from adrenal cortex disorders such as Cushing syndrome.
A nurse should recognize that exophthalmos (protruding eyeballs) may occur in children with which condition?
- Hypothyroidism
- Hyperthyroidism
- Hypoparathyroidism
- Hyperparathyroidism
Explanation: Answer reason: This process is linked to thyroid-stimulating immunoglobulins that drive hyperthyroidism and can produce eye findings independent of hormone level severity. Hypothyroidism more typically presents with fatigue, weight gain, cold intolerance, and bradycardia rather than proptosis. Parathyroid disorders primarily affect calcium and phosphorus balance (tetany, bone changes, renal stones) and do not typically cause protruding eyeballs.
Which chronic complications are associated with diabetes mellitus?
- Angina and dyspnea on exertion.
- Leg ulcers and pulmonary infarcts.
- Retinopathy and neuropathy.
- Fatigue, nausea, and cardiac dysrhythmias.
Explanation: Answer reason: Chronic hyperglycemia causes long-term microvascular injury and nerve ischemia/demyelination, leading to classic diabetic microvascular complications. Retinal capillary damage progresses to diabetic retinopathy with risk of vision loss, while peripheral and autonomic nerve damage produces diabetic neuropathy with sensory loss and pain. Angina and exertional dyspnea can occur from accelerated atherosclerosis in diabetes, but the option is less specific and not the hallmark paired chronic complications tested together. Fatigue, nausea, and dysrhythmias are more consistent with acute metabolic derangements or electrolyte shifts rather than defining chronic diabetic complications.
A client asks the nurse what complications can occur from diabetes mellitus. What is the best response by the nurse?
- Multiple sclerosis
- Diabetic ketoacidosis
- Cardiovascular disease
- Hyperosmolar hyperglycemic nonketotic syndrome (HHNS)
Explanation: Answer reason: This option best fits the question’s broad wording about complications by capturing a common, high-impact, ongoing risk rather than an acute metabolic crisis. The other diabetes-related choices are acute, episodic emergencies that can occur but do not represent the most general complication category asked for. Multiple sclerosis is unrelated to diabetes mellitus as a typical complication.
The nurse admits a client whose initial laboratory tests reveal hyperphosphatemia and hypocalcemia. The nurse suspects which of the following disorders?
- Cushing’s syndrome
- Graves’ disease
- Hypoparathyroidism
- Hypothyroidism
Explanation: Answer reason: This lab pattern is classic for inadequate PTH effect and aligns most directly with parathyroid failure. Cushing’s syndrome is more associated with hyperglycemia and protein catabolism rather than this calcium-phosphate signature. Thyroid disorders (Graves’ or hypothyroidism) do not typically cause the paired finding of low calcium with high phosphate in the same characteristic way.
The nurse is evaluating the long-term success of a child’s control of type 1 DM. Which laboratory test results should the nurse monitor?
- Hemoglobin A1c levels
- Blood insulin levels
- Blood glucose levels
- Urinary glucose levels
Explanation: Answer reason: Hemoglobin A1c reflects mean glycemia over roughly the prior 2–3 months because glucose irreversibly binds to hemoglobin for the lifespan of red blood cells. This makes it the standard lab used to evaluate overall diabetes control and risk for chronic microvascular complications. In contrast, blood glucose and urine glucose reflect short-term or threshold-based changes and can miss sustained hyperglycemia patterns, and insulin levels do not reliably indicate adequacy of control in type 1 diabetes managed with exogenous insulin.
The nurse is assessing the 4-year-old child diagnosed with precocious puberty. Which physical assessment findings should the nurse expect?
- Short stature
- Hypothalamic tumor
- Advanced bone age
- Pubic and axillary hair
Explanation: Answer reason: A key expected physical finding is early appearance of androgen-mediated changes such as pubic and axillary hair. Advanced bone age can occur in precocious puberty but is typically confirmed by radiographic testing rather than being a direct bedside physical finding. A hypothalamic tumor is a possible underlying cause in some cases, but it is not itself a physical assessment finding, and short stature is more a potential long-term outcome from early epiphyseal closure than an expected initial finding.
A client comes to the clinic complaining of sensitivity to cold, weight gain, and dry skin. The nurse recognizes that the client may be suffering from?
- Hypothyroidism.
- Hyperthyroidism.
- Hyperparathyroidism.
- Hypoparathyroidism.
Explanation: Answer reason: These symptoms reflect a decreased metabolic rate due to insufficient thyroid hormone. Reduced thermogenesis explains cold intolerance, while slowed metabolism contributes to weight gain and generalized skin changes such as dryness. Hyperthyroidism typically causes heat intolerance, weight loss, and diaphoresis rather than dry skin. Parathyroid disorders primarily affect calcium/phosphate balance and present with neuromuscular or bone/kidney manifestations, not classic metabolic slowing.
Treatment for Cushing’s syndrome may involve removal of one of the adrenal glands, which could cause a temporary state of which condition?
- Hyperkalemia
- Adrenal insufficiency
- Excessive adrenal hormone
- Syndrome of inappropriate antidiuretic hormone (SIADH)
Explanation: Answer reason: In Cushing’s syndrome, endogenous ACTH drive is often suppressed by prolonged hypercortisolism, so postoperative steroid production may be inadequate for a period of time. This creates a transient adrenal insufficiency risk that may require glucocorticoid replacement and monitoring for hypotension, hypoglycemia, and fatigue. Hyperkalemia can occur with mineralocorticoid deficiency, but the broader and most test-relevant temporary postoperative state is adrenal insufficiency rather than an isolated electrolyte change.
The nurse is admitting a client who is scheduled for a thyroidectomy. The initial serum laboratory tests indicate high levels of T3 and T4. The nurse expects to see which of the following related to levels of thyroid-stimulating hormone (TSH) for this client?
- High
- Low
- Normal
- Not important
Explanation: Answer reason: When circulating T3 and T4 are elevated, they suppress pituitary release of TSH to reduce further thyroid hormone production. This pattern is most consistent with primary hyperthyroidism, where the thyroid is overproducing hormone and pituitary TSH becomes suppressed. A common distractor is “High,” which would be expected in primary hypothyroidism (low T3/T4) rather than in a state of excess thyroid hormone.
A client is diagnosed with a somatotrophin-secreting tumor that could lead to development of acromegaly, Cushing’s syndrome, and hypopituitarism. Which gland is related to this tumor?
- Adrenal gland
- Hypothalamus
- Pituitary gland
- Thyroid gland
Explanation: Answer reason: Excess GH after epiphyseal closure causes acromegaly, matching the clinical consequence described. Pituitary adenomas can also compress normal pituitary tissue, leading to hypopituitarism. Additionally, pituitary tumors can alter ACTH secretion (or mass effect on pituitary regulation), which can contribute to a Cushingoid picture, making this gland the most directly related site.
The nurse is caring for a client who is diagnosed with an unilateral pheochromocytoma and is scheduled for surgery to remove the left adrenal gland. The nurse is aware that the main manifestation of this disease process is which of the following?
- Hypertension
- Renal failure
- Hyponatremia
- Heart failure
Explanation: Answer reason: The dominant clinical manifestation is elevated blood pressure due to intense alpha-adrenergic vasoconstriction, often accompanied by headaches, palpitations, and diaphoresis. Renal failure and heart failure can occur as complications of long-standing severe hypertension, but they are not the primary presenting manifestation. Hyponatremia is more characteristic of disorders like SIADH or adrenal insufficiency rather than catecholamine excess.
The nurse is preparing to care for the stable client with Addison’s disease. Which skin appearance should the nurse expect when performing an assessment?
- Very white, dry, and scaly
- Bronzed and suntanned hue
- Diaphoretic and cyanotic
- Puffy and butterfly-like rash
Explanation: Answer reason: ACTH is derived from POMC, which also increases melanocyte-stimulating activity, leading to diffuse hyperpigmentation that can look “bronzed,” especially in skin creases, scars, and mucous membranes. This finding is characteristic of Addison’s disease and helps distinguish it from secondary adrenal insufficiency, where hyperpigmentation is typically absent. Other listed appearances point to different conditions (e.g., malar rash for lupus) rather than chronic adrenal insufficiency.
The clinic nurse is reviewing the history of the client diagnosed with bacterial vaginosis (BV). Which identified disorder places the client at a higher risk of developing BV?
- Gastroesophageal reflux
- Hypothyroidism
- Cardiovascular disease
- Diabetes mellitus
Explanation: Answer reason: Diabetes is associated with higher rates of vaginitis and dysbiosis, making BV more likely compared with unrelated chronic conditions. In contrast, gastroesophageal reflux and cardiovascular disease do not directly change the vaginal environment or host defenses in a way that increases BV risk. Hypothyroidism also lacks a strong, direct link to BV development compared with the infection-prone state seen in diabetes.
When reviewing the results of radiographic examinations of a child with hypopituitarism, which characteristic should the nurse expect to observe?
- Bone age near normal
- Epiphyseal maturation normal
- Epiphyseal maturation retarded
- Bone maturation greatly retarded
Explanation: Answer reason: On radiographs this presents as a markedly delayed skeletal (bone) age compared with chronological age. Because overall skeletal development is broadly slowed, the retardation is typically more than just a subtle delay in epiphyseal changes. Options describing normal bone age or normal epiphyseal maturation contradict the expected effects of inadequate pituitary growth hormone on skeletal development.
Hyperosmolar hyperglycemic nonketotic syndrome (HHNS) can be differentiated from diabetic ketoacidosis (DK) by which physiologic finding?
- Increased serum osmolarity.
- Hypokalemia.
- Hyperglycemia.
- Absence of ketosis.
Explanation: Answer reason: HHNS typically has enough circulating insulin to prevent lipolysis and ketone production, so significant ketosis and metabolic acidosis are minimal or absent. In contrast, DKA features insulin deficiency leading to fat breakdown, ketone accumulation, and anion-gap metabolic acidosis. While both conditions can present with marked hyperglycemia and dehydration, that overlap makes hyperglycemia a poor differentiator. Increased serum osmolarity is prominent in HHNS but can also be elevated in severe DKA, so the clearest distinguishing physiologic finding is the lack of ketosis.
A client presents with flushed skin, exophthalmos, and perspiration and states that he has been “irritable” and having palpitations. The nurse interprets these symptoms as indicating which disorder?
- Hyperthyroidism
- Hyperparathyroidism
- Hypothyroidism
- Type 1 diabetes mellitus
Explanation: Answer reason: Palpitations, irritability, heat intolerance with sweating, and flushed warm skin are classic hyperthyroid manifestations. Exophthalmos is especially associated with Graves disease due to autoimmune inflammation and tissue expansion behind the eyes. Hypothyroidism would more typically cause cold intolerance, bradycardia, and weight gain, while hyperparathyroidism primarily presents with hypercalcemia-related bone, kidney, and GI symptoms rather than eye and sympathetic signs.
The nurse is teaching a client with hypothyroidism about the thyroid gland. Which of the following statements by the nurse would be the most accurate about which gland controls the secretion of thyroid hormone?
- Adrenal gland
- Parathyroid gland
- Pituitary gland
- Thyroid gland
Explanation: Answer reason: The anterior pituitary releases TSH, which directly stimulates the thyroid gland to synthesize and secrete T3 and T4; therefore the controlling gland in this feedback loop is the pituitary. When circulating T3/T4 levels fall (as in hypothyroidism), pituitary TSH typically rises to drive more hormone production (unless there is central hypothyroidism). The parathyroids regulate calcium via PTH and the adrenal gland regulates corticosteroids/catecholamines, so they do not control thyroid hormone secretion.
The nurse is caring for a client who is diagnosed with hyperparathyroidism. The client asks what conditions may contribute to the development of hyperparathyroidism. What is the most appropriate response by the nurse?
- Chronic renal failure
- Thyroidectomy
- Elevated serum calcium level
- Steroid use
Explanation: Answer reason: This persistent stimulation causes parathyroid hyperplasia and elevated PTH levels over time. In contrast, an elevated serum calcium level typically suppresses PTH via negative feedback, so it is more a consequence of primary hyperparathyroidism than a cause. Thyroidectomy is more associated with hypoparathyroidism if parathyroid tissue is damaged or removed, and chronic steroid use more commonly contributes to bone loss rather than directly causing hyperparathyroidism.
The 10-year-old child is undergoing testing to diagnose possible Cushing’s syndrome. The nurse should plan to prepare the child and parents for which initial tests?
- Glucose tolerance test (GTT)
- Urine or saliva cortisol level
- Dexamethasone suppression test
- Serum 17 -hydroxyprogesterone level
Explanation: Answer reason: Late-night salivary cortisol and 24-hour urinary free cortisol reflect loss of normal circadian rhythm and increased cortisol burden, making them appropriate initial evaluations in suspected Cushing’s syndrome. The dexamethasone suppression test is also used, but it is typically part of confirmatory/etiologic evaluation after initial evidence of cortisol excess is obtained. GTT targets diabetes evaluation rather than diagnosing Cushing’s, and 17-hydroxyprogesterone is used to assess congenital adrenal hyperplasia, a different adrenal disorder.
Which method is considered the definitive treatment for hypopituitarism due to growth hormone deficiency?
- Treatment with desmopressin acetate (DDAVP)
- Replacement of antidiuretic hormone (ADH)
- Treatment with testosterone or estrogen
- Replacement with biosynthetic growth hormone
Explanation: Answer reason: Recombinant (biosynthetic) human growth hormone directly addresses the underlying pituitary hormone deficit and is the standard therapy in pediatric hypopituitarism when GH is deficient. Desmopressin or ADH replacement is used for central diabetes insipidus, not isolated GH deficiency. Sex steroid therapy is reserved for pubertal induction/hypogonadism and does not correct impaired linear growth from GH deficiency.
A client recently diagnosed with prediabetes asks the nurse about the risk factors for developing diabetes mellitus. The nurse is aware that the client’s greatest risk factor is which of the following?
- Obesity
- Japanese descent
- A great-grandparent with diabetes mellitus
- Delivery of a neonate weighing more than 10 lb
Explanation: Answer reason: Among the listed choices, obesity is the strongest and most modifiable predictor of developing diabetes. Japanese descent can increase risk, but it is not typically a larger independent risk than obesity in a person with prediabetes. A remote family history (great-grandparent) and history of delivering a macrosomic infant are risk factors, but they generally confer less overall risk than current obesity.
The nurse is caring for a client with newly diagnosed Cushing’s disease. Which of the following signs and/or symptoms would the nurse expect to find on initial assessment?
- Bruising and hypotension
- Truncal obesity and petechiae
- Hypertension and emaciation
- Weight loss and moon face
Explanation: Answer reason: Central (truncal) obesity is classic from cortisol-driven adipose redistribution, while petechiae (and easy bruising) occur due to protein catabolism leading to thin skin and fragile capillaries. Options featuring hypotension or weight loss conflict with cortisol’s typical effects, which include volume expansion and weight gain. Emaciation is more consistent with cortisol deficiency or other wasting states rather than hypercortisolism.
A client exhibiting exophthalmos, weight loss, and tachycardia would be evaluated by checking the levels of which hormones?
- Amylase, lipase, and trypsin
- Triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH)
- Glucocorticoids, mineralocorticoids, and androgens
- Vasopressin and oxytocin
Explanation: Answer reason: The appropriate evaluation is thyroid function testing to quantify circulating thyroid hormones and the pituitary response. In hyperthyroidism, T3 and/or T4 are elevated, and TSH is typically suppressed from negative feedback (unless rare central causes). The other options reflect pancreatic enzymes, adrenal cortex hormones, or posterior pituitary hormones and do not explain the described constellation of findings.
The nurse is caring for a client who is admitted with untreated hypothyroidism. Which of the following laboratory serum values will the nurse expect to see?
- High T3 and T4 and low thyroid-stimulating hormone (TSH)
- High T3 and T4 and normal TSH
- Low T3 and T4 and low TSH
- Low T3 and T4 and high TSH
Explanation: Answer reason: Reduced circulating thyroid hormone removes negative feedback inhibition on the pituitary and hypothalamus, so TSH increases in an attempt to stimulate the thyroid. This pattern (low T3/T4 with high TSH) is the classic untreated primary hypothyroidism lab profile. By contrast, low TSH with low T3/T4 would suggest central (pituitary/hypothalamic) hypothyroidism rather than the typical untreated presentation.
The nurse is assessing a postmenopausal woman for evidence of heart disease- Which factor contributes to the client’s increased risk for heart disease after menopause?
- A decreased level ofestrogen hormone
- A psychological craving for high-fat food
- An increased level of progesterone hormone
- An intolerance to exercise and physical activity
Explanation: Answer reason: This mechanism directly explains why heart disease risk rises after menopause. Progesterone does not rise postmenopause and is not the main driver of increased cardiovascular risk in this setting. While diet and physical activity influence cardiovascular risk, they are not the core physiologic menopause-related factor being tested here.
A client is admitted with an adrenal malfunction. The nurse demonstrates an understanding of the function of the adrenal gland by identifying which hormones as being released by the adrenal medulla?
- Epinephrine and norepinephrine
- Glucocorticoids, mineralocorticoids, and androgens
- Thyroxine, triiodothyronine, and calcitonin
- Insulin, glucagon, and somatostatin
Explanation: Answer reason: It primarily releases epinephrine and norepinephrine into the bloodstream to increase heart rate, blood pressure, bronchodilation, and glucose availability. In contrast, glucocorticoids, mineralocorticoids, and androgens are produced by the adrenal cortex (zona fasciculata, glomerulosa, and reticularis). The other options describe hormones produced by the thyroid gland and pancreatic islet cells, not the adrenal gland.
The nurse admits a client with a diagnosis of chronic adrenal insufficiency. The nurse is aware that adrenal insufficiency develops secondary to inadequate secretion of which pituitary hormone?
- Adrenocorticotropic hormone (ACTH)
- Antidiuretic hormone (ADH)
- Follicle-stimulating hormone (FSH)
- Thyroid-stimulating hormone (TSH)
Explanation: Answer reason: The anterior pituitary hormone that directly drives cortisol synthesis in the adrenal cortex is ACTH. When ACTH is deficient (e.g., pituitary disease or suppression after exogenous steroids), the adrenal glands underproduce glucocorticoids and may atrophy over time. ADH primarily regulates water balance, TSH targets the thyroid, and FSH regulates gonadal function, so they do not directly cause adrenal cortical hypofunction.
The nurse is admitting a client who is suspected of having adrenal insufficiency, or Addison’s disease. An initial serum chemistry test is done. The nurse expects to see which of the following abnormalities?
- Hyponatremia and hyperkalemia
- Hypernatremia and hypokalemia
- Hyperglycemia and hypernatremia
- Hypercalcemia and hyperglycemia
Explanation: Answer reason: Low aldosterone reduces renal sodium reabsorption and impairs potassium and hydrogen excretion, producing hyponatremia with hyperkalemia and often volume depletion. Cortisol deficiency can also contribute to low serum sodium via increased ADH and reduced free-water clearance. Options featuring hypernatremia/hypokalemia align more with excess mineralocorticoid effect, and hyperglycemia is less consistent because cortisol deficiency tends to lower glucose.
The nurse is caring for a 47-year-old client admitted with joint pain and weakness. The client describes a gradual coarsening of facial features and enlargement of hands and feet over the past year. The nurse is aware that these are early clinical manifestations of which condition?
- Acromegaly
- Cushing’s syndrome
- Graves’ disease
- Pheochromocytoma
Explanation: Answer reason: This leads to enlarged hands and feet, coarsened facial features, and musculoskeletal complaints such as joint pain and weakness from tissue overgrowth and arthropathy. Cushing’s syndrome is characterized by hypercortisolism findings (central obesity, striae, proximal muscle wasting) rather than acral enlargement and facial coarsening. Graves’ disease produces hyperthyroid symptoms and ophthalmopathy, and pheochromocytoma presents with episodic headaches, diaphoresis, and hypertension, not gradual somatic enlargement.
A 37-year-old client complains of muscle weakness, anorexia, and darkening of his skin. The nurse reviews his laboratory data and notes findings of low serum sodium and high serum potassium levels. The nurse recognizes that these signs and symptoms are associated with which condition?
- Addison’s disease
- Cushing’s disease
- Diabetes insipidus
- Thyrotoxic crisis
Explanation: Answer reason: Aldosterone deficiency leads to renal sodium wasting (hyponatremia) and impaired potassium excretion (hyperkalemia), producing weakness and anorexia. Elevated ACTH occurs due to loss of negative feedback and increases melanocyte stimulation, explaining skin hyperpigmentation. In contrast, Cushing’s syndrome typically produces hypernatremia and hypokalemia from excess corticosteroid/mineralocorticoid effects, not the electrolyte pattern shown.
The nurse is caring for a client who is diagnosed with Addison’s disease. While completing the initial assessment and reviewing serum laboratory test results, the nurse expects to find which of the following signs and symptoms?
- Weight gain and loss of skin pigment
- Fatigue and muscle weakness
- Hypertension and hypernatremia
- Increased appetite and hypokalemia
Explanation: Answer reason: Cortisol deficiency contributes to fatigue, while aldosterone deficiency can cause dehydration and electrolyte disturbances that worsen muscle weakness. By contrast, Addison’s classically presents with hypotension and hyponatremia (and often hyperkalemia), not hypertension and hypernatremia. It also tends toward weight loss and hyperpigmentation rather than weight gain and loss of skin pigment.
The nurse is admitting a client who is diagnosed with untreated Cushing's syndrome. While performing the initial assessment, the nurse can expect to see which of the following signs and symptoms?
- Moon face and truncal obesity
- Weight loss and heat intolerance
- Changes in skin texture and low body temperature
- Polyuria and dehydration
Explanation: Answer reason: This produces centripetal (truncal) weight gain with facial rounding (“moon face”) and often a dorsocervical fat pad. Weight loss with heat intolerance is more consistent with hyperthyroidism, not Cushing’s. Polyuria can occur if steroid-induced hyperglycemia develops, but it is not as defining for initial recognition as the classic body habitus changes.
The nurse is providing health maintenance education to a group of clients. As the nurse talks about thyroid disorders, one of the clients asks about risk factors for Graves’ disease. Which of the following would be most at risk for developing this disease?
- A 40-year-old male
- A 30-year-old female
- A 15-year-old female
- A 35-year-old male
Explanation: Answer reason: The risk is highest in women roughly 20–40 years old, making this choice the best match to the classic epidemiology. Male sex is a relative protective factor compared with female sex, so both male options are less likely. While Graves’ can occur in adolescents, it is less common than in reproductive-age adults, so the teenage female is a weaker fit than the 30-year-old female.
The nurse is providing education about the thyroid gland and aging to a group of nursing students. Which of the following would be appropriate to include in this discussion?
- The thyroid gland increases in size with increasing age.
- Older adults require higher doses of replacement therapy.
- Thyroid hormone secretion increases with age.
- The basal metabolic rate decreases with age.
Explanation: Answer reason: Aging is associated with a general decline in metabolic activity and lean body mass, leading to a lower basal metabolic rate even when thyroid function tests are normal. This statement accurately reflects a common physiologic change seen in older adults and helps explain age-related tendencies toward cold intolerance, weight gain, and reduced energy expenditure. In contrast, thyroid hormone secretion does not typically increase with age, and the thyroid gland more often shows atrophy/fibrosis rather than enlargement. Replacement therapy dosing in older adults is usually started lower and titrated cautiously due to cardiac sensitivity, not routinely increased.
An unemployed client with no health insurance hasn’t filled his prescriptions for some time. According to his roommate, the client has been “getting sicker by the day.” Which problem suggests the client isn’t taking his prescribed levothyroxine (Synthroid)?
- Diarrhea and vomiting
- Rapid heart rate
- Warm, dry, flushed skin
- Temperature of 94° F (34.4° C)
Explanation: Answer reason: Temperature of 94° F (34.4° C) Untreated hypothyroidism lowers basal metabolic rate and heat production, so hypothermia and cold intolerance are hallmark findings when thyroid hormone replacement is missed. A low core temperature fits progressive thyroid hormone deficiency and can precede severe decompensation (myxedema coma). In contrast, rapid heart rate, warm flushed skin, and GI hypermotility symptoms are more consistent with excess thyroid hormone (hyperthyroidism) rather than lack of levothyroxine. Therefore, the low temperature most strongly indicates the client is not taking prescribed replacement therapy.
A nonpregnant client tells the nurse that two recent fasting blood glucose results were 132 mg/dl and 146 mg/dl. The nurse should expect which of the following actions to occur?
- These are normal results; no further action is needed.
- These results indicate diabetes mellitus; further follow-up is needed.
- The fasting blood glucose tests should be repeated two more times.
- The client should be scheduled for an HbA1C test.
Explanation: Answer reason: Diabetes mellitus can be diagnosed with fasting plasma glucose values ≥ 126 mg/dL on two separate occasions in a nonpregnant adult. Both reported fasting results exceed this threshold, so the pattern is consistent with diabetes rather than normal or isolated impaired fasting glucose. The appropriate next step is confirmation/medical evaluation and initiation of diabetes care planning rather than dismissing the findings. While an HbA1c can be used as an additional diagnostic/monitoring test, the key expected action is follow-up for diabetes based on the already diagnostic fasting values.
The nurse is teaching the parents of a neonate newly diagnosed with hypothyroidism about the condition. What is the most important information for the nurse to provide?
- “A large goiter in a neonate doesn’t present a problem.”
- “Preterm neonates usually aren’t affected by hypothyroidism.”
- “Usually, the neonate exhibits obvious signs of hypothyroidism.”
- “The severity of the disorder depends on the amount of thyroid tissue present.”
Explanation: Answer reason: Congenital hypothyroidism most commonly results from thyroid dysgenesis (absent, ectopic, or hypoplastic gland) or dyshormonogenesis, and the degree of hormone deficiency generally tracks with how much functional thyroid tissue exists. This is key teaching because it explains why some infants have profound hypothyroidism while others have milder disease that may be detected only by newborn screening. A large neonatal goiter can be clinically significant (e.g., airway compromise) and is not automatically benign. Also, neonates often have few or subtle early findings, so relying on “obvious signs” is unsafe and underscores the importance of screening and timely treatment.
The nurse is obtaining the health history of a child with diabetes insipidus. The nurse expects the history to include which findings?
- Delayed closure of the fontanels, coarse hair, and hypoglycemia in the morning
- Gradual onset of personality changes, lethargy, and blurred vision
- Vomiting early in the morning, headache, and decreased thirst
- Abrupt onset of polyuria, nocturia, and polydipsia
Explanation: Answer reason: This results in large volumes of dilute urine with compensatory excessive thirst, and nighttime urination is common due to persistent high urine output. The presentation can appear relatively sudden to caregivers when the child begins voiding frequently and drinking constantly. A common distractor is diabetes mellitus, which can cause blurred vision and lethargy, but DI is defined by water balance symptoms rather than hyperglycemia-related findings.
The nurse is admitting a client who is diagnosed with a new onset of type 1 diabetes mellitus. While performing the initial physical assessment and nursing history, the nurse expects to find which of the following signs/symptoms?
- Polydipsia, polyuria, and weight loss
- Weight gain, tiredness, and bradycardia
- Irritability, diaphoresis, and tachycardia
- Diarrhea, abdominal pain, and weight loss
Explanation: Answer reason: Glucose spilling into the urine pulls water with it, causing frequent urination and dehydration that triggers excessive thirst. Because cells cannot effectively use glucose without insulin, the body breaks down fat and muscle for energy, producing unintended weight loss. A common distractor is adrenergic symptoms like diaphoresis and tachycardia, which more strongly suggest hypoglycemia rather than new-onset untreated hyperglycemia.
The 10-year-old child with a 6-year history of type 1 DM has been seen in a clinic for enuresis over the past 2 weeks. Which conclusion by the nurse regarding the likely cause of the enuresis is correct?
- Sustained blood glucose levels lower than normal
- Acquired adrenoecortieal hyperfunction
- Sustained blood glucose levels higher than normal
- Acquired syndrome of inappropriate antidiuretic hormone (SIADH)
Explanation: Answer reason: In a child with type 1 diabetes, new enuresis over 2 weeks is most consistent with inadequate glycemic control producing excessive urine output during sleep. Hypoglycemia does not produce osmotic diuresis and is more associated with adrenergic/neuroglycopenic symptoms. SIADH causes water retention and concentrated urine rather than increased urine volume, making it an unlikely cause of bedwetting here.
A child has been brought to a pediatrician’s office for concerns about growth. The physician suspects hypopituitarism. The mother asks the nurse which test will be done to determine the diagnosis. Which response by the nurse would be appropriate?
- Hypersecretion of thyroid hormone
- Increased reserves of growth hormone
- Hyposecretion of antidiuretic hormone (ADH)
- Decreased reserves of growth hormone
Explanation: Answer reason: Diagnostic evaluation commonly uses stimulation testing to assess pituitary growth hormone reserve because random levels are pulsatile and unreliable. A reduced response/low reserve on stimulation supports the diagnosis of growth hormone deficiency from pituitary dysfunction. Thyroid hormone excess would suggest hyperthyroidism rather than pituitary failure, and ADH deficiency is a posterior pituitary problem that presents primarily as diabetes insipidus rather than growth delay.
A 40-year-old client is curious about visible appearance changes related to menopause. In general, menopausal clients experience?
- Bone loss and fractures.
- Loss of muscle mass and increased fat tissue.
- Improved skin turgor and elasticity.
- A reduction in waist size.
Explanation: Answer reason: Declining estrogen during the menopausal transition contributes to unfavorable body composition changes, including decreased lean muscle mass and a relative increase in adiposity. Clinically this often appears as weight redistribution and central fat accumulation, making it a “visible appearance” change. Improved skin turgor is inconsistent with menopause, as estrogen loss tends to reduce collagen and skin elasticity. Bone loss can occur, but fractures are not a typical early visible appearance change compared with shifts in muscle and fat.
The nurse is caring for a middle-aged athletic client with hyperparathyroidism. The client has been further diagnosed with kidney stones. The client is currently showing signs of apathy and depression, and despite the client’s athleticism, the nurse’s assessment finds flabby musculature. Based on the diagnosis and signs and symptoms, the nurse suspects which of the following conditions?
- Hypercalcemia
- Hypocalcemia
- Hypernatremia
- Hyponatremia
Explanation: Answer reason: Elevated calcium commonly causes renal calculi from hypercalciuria and is classically associated with neuropsychiatric changes such as lethargy, apathy, and depression. Proximal muscle weakness with decreased muscle tone can present as “flabby” musculature, fitting the neuromuscular effects of high calcium. In contrast, hypocalcemia more typically produces neuromuscular excitability (tetany, paresthesias, Chvostek/Trousseau) rather than stones and depressive/apathic features.
The parents of a child who’s going through testing for hypopituitarism ask the nurse what type of test results they should expect. The nurse’s response should be based on which factor?
- Measurement of growth hormone will occur only one time.
- Growth hormone levels are decreased after strenuous exercise.
- There will be increased overnight urine growth hormone concentration.
- Growth hormone levels are elevated 45 to 90 minutes following the onset of sleep.
Explanation: Answer reason: Growth hormone secretion is pulsatile and strongly linked to slow-wave sleep, so random daytime levels can be misleading when evaluating suspected deficiency. The most reliable physiologic rises occur shortly after sleep onset, which explains why testing strategies may incorporate overnight sampling or stimulation paradigms rather than a single baseline value. Strenuous exercise typically increases, not decreases, growth hormone secretion, making that distractor physiologically incorrect. Overnight urinary growth hormone is not expected to be increased in hypopituitarism and is not a core rationale for interpreting results compared with sleep-related pulsatility.
A client newly diagnosed with diabetic ketoacidosis has a serum glucose level of 485 mg/dl. After treatment, the serum glucose level drops to 185 mg/dl, and the cardiac monitor starts to show ventricular ectopic beats. Which factor is the most probable cause factor in arrhythmia?
- Decreased serum chloride level
- Decreased serum potassium level
- Elevated serum glucose level
- Elevated serum sodium level
Explanation: Answer reason: Hypokalemia increases myocardial irritability and is a classic precipitant of ventricular ectopy and more dangerous ventricular dysrhythmias. A rapid glucose drop itself does not directly cause ventricular ectopic beats in the way potassium shifts do. Chloride and sodium abnormalities are less directly arrhythmogenic than low potassium in this clinical context.
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