Physiology Practice Test 2
Physiology NCLEX Practice Test
Physiology is a key topic within the NCLEX test plan, located under Nursing Science → Clinical Foundations → Physiology. This section explores body functions to strengthen nursing understanding of assessment and intervention planning. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 2nd part of the Physiology series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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In the Physiology Study Cards section, shared by real NCLEX candidates, you’ll find concise summaries and high-yield insights related to the most tested concepts. It’s a perfect space to reinforce challenging topics and sharpen your recall through quick, focused repetitions. Short, powerful, and repeatable!
Physiology Practice Test 2
A nurse is reviewing the effects of the autonomic nervous system on vital organs. Which physiological change would most likely occur when the sympathetic nervous system is activated during a “fight-or-flight” response?
- Decreased heart rate and bronchoconstriction
- Increased gastrointestinal motility and saliva production
- Increased heart rate and bronchodilation
- Decreased blood glucose and peripheral vasoconstriction
Explanation: Answer reason: The sympathetic nervous system prepares the body for stress by stimulating the release of catecholamines (epinephrine and norepinephrine). These neurotransmitters increase heart rate and contractility to enhance blood flow to vital organs, and cause bronchodilation to improve oxygen intake. Parasympathetic effects are the opposite, promoting rest and digestion.
A 4-week-old male infant is brought to the emergency department because of persistent vomiting. Examination shows dry mucous membranes and an olive-shaped mass palpated in the right upper quadrant of the abdomen. Which of the following acid–base abnormalities is most likely in this patient? (Columns: pH, PaCO2 (mm Hg), HCO3 (mEq/L))?
- 7.10, 80, 24
- 7.40, 40, 24
- 7.55, 46, 42
- 7.62, 21, 21
Explanation: Answer reason: Pyloric stenosis causes persistent nonbilious vomiting with loss of gastric HCl leading to hypochloremic metabolic alkalosis. Expected ABG: elevated pH and HCO3 with compensatory hypoventilation (increased PaCO2). Option C matches this pattern.
Gastric suction can cause ?
- Metabolic acidosis
- Respiratory acidosis
- Metabolic alkalosis
- Respiratory alkalosis
Explanation: Answer reason: Removal of gastric contents via suction leads to loss of hydrochloric acid (H+ and Cl−), producing a hypochloremic metabolic alkalosis.
Main nitrogenous product formed in man is?
- Urea
- Ammonia
- Uric acid
- Ammonium nitrate
Explanation: Answer reason: Humans are ureotelic; the liver converts toxic ammonia to urea via the urea cycle, which is the primary nitrogenous waste excreted.
Which one of the following values would represent a normal pH value for blood?
- 6.80-7.0
- 7.00-7.35
- 7.35-7.45
- 7.45-8.00
Explanation: Answer reason: Normal arterial blood pH is maintained between 7.35 and 7.45.
What is the normal oral temperature range?
- 36.7-38 degrees C
- 35.4-37.4 degrees C
- 36-38 degrees C
- 34.5-36 degrees C
Explanation: Answer reason: Accepted adult oral temperature range is approximately 36–38 °C; the other options are either too low or have an inappropriately low minimum for normal oral temperature.
The exchange of material takes place?
- Only by diffusion
- Only by active transport
- Only by pinocytosis
- All of these
Explanation: Answer reason: Cells exchange materials via multiple mechanisms including diffusion, active transport, and pinocytosis; therefore all listed methods are involved.
Sympathetic nervous system is known as?
- Fight and flight
- Rest and digest
- Both (A) and (B)
- None of above
Explanation: Answer reason: The sympathetic division mediates the fight-or-flight response; parasympathetic is rest-and-digest. Therefore option A is correct.
Which organ is primarily responsible for detoxifying the body?
- Liver
- Kidneys
- Lungs
- Pancreas
Explanation: Answer reason: The liver is the primary detoxification organ, performing biotransformation of toxins and drugs (e.g., via cytochrome P450) before excretion; kidneys mainly excrete water‑soluble wastes.
Each compartment of the body has a water-fluid distribution movement of its own. These fluids move and distribute themselves between these compartments via a process known as?
- Active transport.
- Diffusion.
- Filtration.
- Osmosis.
Explanation: Answer reason: Water moves between body compartments primarily by osmosis across semipermeable membranes driven by osmotic gradients; diffusion and active transport describe solute movement, and filtration is pressure-driven bulk flow.
Both the intracellular and extracellular fluids are made up of many different electrolytes, but the most abundant intracellular positively charged electrolyte is?
- Calcium.
- Chloride.
- Potassium.
- Sodium.
Explanation: Answer reason: Potassium is the principal intracellular cation; sodium is the main extracellular cation, and chloride is an anion. Calcium is mostly extracellular or stored in bone.
What is the correct sequence for how the Renin-Angiotensin-Aldosterone System (RAAS) works to increase blood pressure?
- Angiotensin I -> Angiotensin II -> ACE -> Renin -> Angiotensinogen
- Renin -> Angiotensinogen -> Angiotensin I -> ACE -> Angiotensin II
- Renin -> Angiotensin I -> Angiotensinogen -> ACE -> Angiotensin II
- Angiotensinogen -> Renin -> ACE -> Angiotensin I -> Angiotensin II
Explanation: Answer reason: Renin converts angiotensinogen to angiotensin I; ACE then converts angiotensin I to angiotensin II, which raises blood pressure.
A solution having the same tonicity as that of body fluid or plasma is considered as?
- Hypertonic
- Hypotonic
- Isotonic
- Supersaturated
Explanation: Answer reason: An isotonic solution has the same effective osmotic pressure as plasma/body fluids; thus water movement across membranes is balanced.
Normal body temperature is?
- 36.5°C
- 37°C
- 38°C
- 35°C
Explanation: Answer reason: The commonly accepted normal core body temperature is 37°C; 36.5–37.5°C is a normal range, but the standard single value is 37°C.
What is the normal pH range of the blood and what ratio of base to acid does this reflect?
- 7.32 to 7.42; 25 to 2
- 7.35 to 7.45; 20 to 1
- 7.32 to 7.42; 28 to 2
- 7.35 to 7.45; 30 to 1
Explanation: Answer reason: Normal arterial blood pH is 7.35–7.45, maintained by a bicarbonate to carbonic acid ratio of about 20:1.
With an oxygen debt, which of the following is observed in muscle?
- Low levels of Lactic acid
- High levels of Glycogen
- Low levels of ATP
- High levels of Calcium
Explanation: Answer reason: During oxygen debt after anaerobic exercise, ATP and phosphocreatine stores are depleted while lactic acid accumulates and glycogen is reduced. Therefore low ATP is observed.
Dehydration means loss of which of the following?
- Blood
- Water
- Glucose
- Plasma
Explanation: Answer reason: Dehydration is defined as a deficit of body water; it is not a loss of blood, glucose, or plasma specifically.
What is the normal temperature of the human body?
- 98.4°C
- 99.0°C
- 99.0°F
- 99.0°C
Explanation: Answer reason: Normal core body temperature is about 37°C (98.6°F); among the options, 99.0°F is the only value in that physiologic range. The Celsius choices are far too high.
What is the percentage of water in a newborn infant's body?
- 50%
- 60%
- 70%
- 80%
Explanation: Answer reason: Newborns have a high total body water content, approximately 75–80% of body weight; 80% is the best option.
A type of heat loss that occurs when the heat is dissipated by air current?
- Convection
- Conduction
- Radiation
- Evaporation
Explanation: Answer reason: Heat loss via movement of air or fluid over the skin is convection. Conduction is direct contact, radiation is infrared heat transfer, and evaporation is heat loss via vaporization of moisture.
Tick the second messenger of G-protein-coupled (metabotropic) receptor?
- Adenylyl cyclase
- Sodium ions
- Phospholipase C
- CAMP
Explanation: Answer reason: In GPCR signaling, cAMP functions as a classic intracellular second messenger. Adenylyl cyclase and phospholipase C are effector enzymes, and sodium ions are not typical second messengers.
When water moves from an area where there is more water to an area where there is less, the process is called _____?
- Transfusion
- Diffusion
- Osmosis
- Passive transport
Explanation: Answer reason: Movement of water across a semipermeable membrane from higher water concentration (lower solute) to lower water concentration (higher solute) is osmosis.
The control mechanism in which the effector decreases the effect of the original stimulus is called?
- Positive feedback
- Negative feedback
- Both A & B
- None of the above
Explanation: Answer reason: In negative feedback the effector response counteracts or decreases the original stimulus, maintaining homeostasis.
Which stage of sleep is responsible for the incidence of dreams?
- REM sleep
- Slow wave sleep
- Stage 2NREM sleep
- All of the above
Explanation: Answer reason: Dreaming occurs predominantly during REM sleep; NREM stages (including slow-wave and stage 2) are not the primary dreaming stages.
The ability of the body to maintain a relatively stable internal condition under changing external conditions is defined as?
- Negative feedback.
- Positive feedback.
- Homeostasis.
- Hematopoiesis.
Explanation: Answer reason: Homeostasis is the process of maintaining a stable internal environment; negative feedback is a mechanism used to achieve it, and hematopoiesis is blood cell formation.
Sympathetic stimulation is mediated by?
- Release of norepinephrine from nerve terminals
- Activation of adrenoreceptors on postsynaptic sites
- Release of epinephrine from the adrenal medulla
- All of the above
Explanation: Answer reason: Sympathetic effects result from norepinephrine release by sympathetic nerve terminals and epinephrine release from the adrenal medulla, both acting on adrenergic (adreno)receptors; therefore all listed mechanisms mediate sympathetic stimulation.
The process by which the body regulates its temperature is referred to as?
- Chemotropism
- Osmosis
- Homeostasis
- Hemostasis
Explanation: Answer reason: Temperature regulation is a classic example of homeostasis, the body's maintenance of internal equilibrium.
What is the process by which water flows from the soil into the roots?
- Diffusion
- Osmosis
- Active diffusion
- Facilitated diffusion
Explanation: Answer reason: Water enters root cells across a semipermeable membrane down its water potential gradient, which is osmosis, not simple diffusion, facilitated diffusion, or an active process.
A process of heat loss which involves the transfer of heat from one surface to another is?
- Radiation
- Conduction
- Convection
- Evaporation
Explanation: Answer reason: Conduction is heat transfer by direct contact from one surface to another; radiation, convection, and evaporation are different mechanisms.
Identify which situation does not contribute to a reduced body temperature?
- Exercise
- Anaesthesia
- Hibernation
- Hypothermia
Explanation: Answer reason: Exercise increases metabolic heat production and typically raises core temperature, whereas anaesthesia, hibernation, and hypothermia are associated with decreased body temperature.
What does the pancreas secrete?
- Insulin
- Glucagon
- Enzymes
- All Of These
Explanation: Answer reason: The pancreas has endocrine cells that secrete insulin and glucagon, and exocrine acinar cells that secrete digestive enzymes.
What form of food does the liver store?
- Glycogen
- Glucose
- ATP
- Albumen
Explanation: Answer reason: The liver stores carbohydrates as glycogen for later release as glucose. Glucose circulates in blood, ATP is energy currency not a storage form, and albumen is a protein.
How many types of respiration are there?
- One
- Two
- Three
- Four
Explanation: Answer reason: Respiration is commonly classified into two types: aerobic and anaerobic (also described as external and internal in physiology), hence two.
In which phase of the cell cycle are chromosomes inactive, condensed, and not transcribed into messenger RNA?
- G1 phase
- S phase
- M phase
- G2 phase
Explanation: Answer reason: During mitosis (M phase) chromosomes are highly condensed and transcription is largely silenced, making them inactive and not transcribed into mRNA.
Which of the following is NOT an example of a transport system?
- Blood
- Lymphatic system
- Nervous system
- Cardiovascular system
Explanation: Answer reason: Blood, lymphatic, and cardiovascular systems transport substances throughout the body, whereas the nervous system primarily transmits electrical signals and does not serve as a transport system for fluids or solutes.
What is the most important electrolyte of intracellular fluid?
- Sodium
- Chloride
- Potassium
- Calcium
Explanation: Answer reason: Potassium is the principal intracellular cation; sodium and chloride are mainly extracellular, and calcium is largely extracellular/bone.
Dehydration in the human body is caused due to the deficiency of which substance?
- Vitamin
- Salt
- Hormone
- Water
Explanation: Answer reason: Dehydration is defined as a deficit of body water; thus the deficiency is water.
What is the normal pH range for human blood?
- 6.5 to 7.0
- 7.35 to 7.45
- 7.5 to 8.0
- 8.0 to 8.5
Explanation: Answer reason: Arterial blood pH is tightly regulated within 7.35–7.45; values outside this range indicate acidosis or alkalosis.
What percentage of the human body is water?
- 30%
- 50%
- 70%
- 80%
- None of these
Explanation: Answer reason: Average human body water content is commonly cited as about two-thirds of body weight, approximated to 70%.
Which condition may cause hypokalemia?
- Diabetic ketoacidosis
- Addison’s disease
- Metabolic alkalosis
- Chronic renal failure
- Cushing’s syndrome
Explanation: Answer reason: In metabolic alkalosis hydrogen ions move out of cells and potassium shifts into cells, lowering serum K+ and causing hypokalemia.
An excessive vomiting and hemorrhage leads to which condition?
- Hypovolemia
- Hypervolemia
- Fluid overload
- Oedema
Explanation: Answer reason: Vomiting and hemorrhage cause significant fluid and blood loss, reducing intravascular volume and leading to hypovolemia. Hypervolemia, fluid overload, and edema indicate excess fluid.
Which organ can function after death?
- Skin
- Brain
- Heart
Explanation: Answer reason: Skin cells can remain viable and continue limited metabolic activity and division for hours after death, whereas brain and heart function cease rapidly due to hypoxia.
In the human body, which organ has the maximum power of regeneration?
- Brain
- Kidney
- Liver
- Stomach
Explanation: Answer reason: The liver possesses the greatest regenerative capacity in humans; hepatocytes proliferate to restore liver mass after injury or partial hepatectomy.
Which organ is known as the blood bank in the body?
- Kidney
- Liver
- Spleen
- Lung
Explanation: Answer reason: The spleen acts as a reservoir for blood and can release stored blood into circulation when needed, hence it is called the body’s blood bank.
What percentage of the human body is composed of water?
- 50%
- 60%
- 70%
- 80%
Explanation: Answer reason: In the average adult, total body water accounts for about 60% of body weight, varying with age, sex, and body fat.
What biochemical abnormality is produced by repeated vomiting?
- Metabolic acidosis
- Metabolic alkalosis
- Uraemia
- Septicaemia
Explanation: Answer reason: Repeated vomiting causes loss of gastric HCl, decreasing hydrogen ions and increasing serum bicarbonate, leading to metabolic alkalosis.
What is the normal human body temperature in Fahrenheit?
- 81.1 °F
- 37.5 °F
- 98.6 °F
- 95.9 °F
Explanation: Answer reason: Normal core body temperature is approximately 37°C, which equals 98.6°F.
Which type of solution causes water to shift from cells to plasma?
- Alkaline
- Hypotonic
- Isotonic
- Hypertonic
Explanation: Answer reason: A hypertonic extracellular solution has higher osmolality than the intracellular fluid, drawing water out of cells into the plasma. Hypotonic moves water into cells; isotonic causes no net shift; alkaline refers to pH, not tonicity.
What is the normal temperature of the human body?
- 46°C
- 89°C
- 98.6°F
- 37°C
Explanation: Answer reason: Normal core body temperature is about 37°C (equivalent to 98.6°F); the other Celsius options are far from physiologic.
Skeletal muscle relaxation and paralysis can occur from interruption of functions at several sites, including all of the following EXCEPT?
- Nicotinic acetylcholine receptors
- Muscarinic acetylcholine receptors
- The motor end plate
- Contractile apparatus
Explanation: Answer reason: Skeletal muscle neuromuscular junctions use nicotinic, not muscarinic, acetylcholine receptors. Paralysis can result from dysfunction of nicotinic receptors, the motor end plate, or the contractile apparatus; muscarinic receptors are not involved.
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