Pathology Practice Test 15
Pathology NCLEX Practice Test
Pathology is a key topic within the NCLEX test plan, located under Nursing Science → Clinical Foundations → Pathology. This section connects disease mechanisms to clinical manifestations and nursing priorities for safe patient care. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 15th part of the Pathology series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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Pathology Practice Test 15
Viral meningitis usually resolves within?
- 2–4 days
- 7–10 days
- 1 month
- 3 months
Explanation: Answer reason: Symptoms and clinical course usually improve over about a week, with many cases resolving within roughly 7–10 days. A timeframe of only a few days is often too short for meningeal inflammation and associated systemic symptoms to fully subside. Durations of 1–3 months suggest chronic meningitis etiologies (e.g., TB, fungal) or complications rather than an uncomplicated viral course.
Incidence of postpartum psychosis is approximately?
- 1 in 10
- 1 in 100
- 1 in 500
- 1 in 1000
Explanation: Answer reason: 1–0.2% of births. That epidemiologic range corresponds most closely to about 1 per 1000 deliveries (and can be cited as up to ~1–2 per 1000). The higher-frequency distractors (1 in 100 and 1 in 10) align more with postpartum depression and “baby blues,” respectively, rather than psychosis. Recognizing the low incidence is important because, despite rarity, the condition has high risk for suicide/infanticide and requires urgent specialist care.
Which condition is a degenerative disease primarily of the joint cartilage?
- Osteoarthritis
- Rheumatoid arthritis
- Gout
- Osteoporosis
Explanation: Answer reason: This directly matches the condition described as primarily affecting joint cartilage. Rheumatoid arthritis is primarily an autoimmune inflammatory synovitis leading to pannus formation and subsequent cartilage erosion rather than primary cartilage degeneration. Gout is due to monosodium urate crystal deposition causing episodic inflammatory arthritis, and osteoporosis is decreased bone mass with fracture risk rather than a cartilage disorder.
Which of the following terms best describes the pain associated with appendicitis?
- Aching
- Fleeting
- Intermittent
- Steady
Explanation: Answer reason: This evolution is typically described as persistent/steady pain rather than brief, passing discomfort. “Fleeting” suggests transient pain and is inconsistent with an inflamed appendix, and “intermittent” is more typical of colicky pain from obstruction (e.g., biliary or renal colic). Although early discomfort can be vague, the hallmark clinical descriptor as it progresses is steady pain that intensifies and localizes to the right lower quadrant.
Hepatic encephalopathy develops when the blood level of which substance increases?
- Ammonia
- Amylase
- Calcium
- Potassium
Explanation: Answer reason: Elevated ammonia crosses the blood-brain barrier and is converted to glutamine in astrocytes, causing osmotic swelling and impaired neurotransmission that manifests as altered mental status and asterixis. This mechanism directly links rising serum ammonia with worsening encephalopathy severity in liver failure or portosystemic shunting. Amylase more specifically reflects pancreatic injury, while calcium and potassium disturbances can affect cognition but are not the hallmark pathophysiologic driver of hepatic encephalopathy.
A child presents to the emergency department with a maculopapular rash and small white spots on the inside of their cheeks. What condition should the nurse suspect?
- Measles
- Paramyxovirus
- Parvovirus B19
- Rubella
Explanation: Answer reason: A maculopapular rash that follows is consistent with the typical progression of measles. Rubella can also cause a maculopapular rash but does not characteristically produce Koplik spots. Parvovirus B19 more often presents with a “slapped cheek” facial rash and lacy body rash rather than buccal mucosal white spots.
A nurse is caring for a patient with suspected lyme disease. The patient presents with a ring-shaped, bullseye lesion. Which stage of lyme disease does this finding indicate?
- Stage I
- Stage II
- Stage III
- Unstageable
Explanation: Answer reason: This corresponds to stage I disease, before hematogenous dissemination produces neurologic, cardiac, or migratory joint findings. Stage II is characterized by early disseminated manifestations (e.g., facial palsy, meningitis, carditis) rather than an isolated skin lesion. Stage III refers to late/persistent disease such as Lyme arthritis or late neurologic complications occurring months to years later.
Which of the following information is true about congenital disorders?
- It develops shortly after birth
- It is a condition that appears prior to delivery
- Congenital disorders result from a stressful labor and delivery
- It can be acquired by infants from exposure to pathogenic organisms
Explanation: Answer reason: A disorder can be present before delivery even if it is not diagnosed until after birth, which makes timing of origin (prenatal) the key idea. Stressful labor/delivery may contribute to birth injury but does not cause congenital anomalies, which are formed earlier. Postnatal exposure to pathogens describes acquired infections, not congenital disorders.
A nurse is caring for a patient with acute lymphoblastic leukemia (ALL). Which of the following is the most likely age range of the patient?
- 3-10 years.
- 25-35 years.
- 45-55 years.
- Over 60 years.
Explanation: Answer reason: ALL is classically a pediatric malignancy, with the highest incidence in early childhood (often around ages 2–5) and commonly presenting throughout the grade-school years. The stem asks for epidemiologic likelihood rather than management, so the age group most associated with this diagnosis is the youngest range offered. In contrast, acute myeloid leukemia and chronic leukemias are more typical of older adults, making the adult ranges less likely for ALL. Therefore, the childhood range best fits the expected demographic pattern for ALL.
Which of these bizarre conditions has not been featured on Grey’s Anatomy?
- Tree Man Syndrome
- Fish Odor Syndrome
- Absorbing a Twin in the Womb
- Man Growing Horns
Explanation: Answer reason: The other options correspond to highly sensationalized, visually dramatic presentations that are commonly portrayed in medical dramas and have been publicized in pop-media medical segments. In contrast, trimethylaminuria (the basis of this option) is a metabolic condition with a malodor presentation that is less visually distinctive and less commonly dramatized. Therefore, among the choices, it is the best answer for the one not featured.
In TB meningitis, CSF shows?
- Clear fluid, lymphocytes, high protein, low glucose
- Purulent fluid, neutrophils
- Normal glucose
- RBC predominance
Explanation: Answer reason: Protein rises due to increased blood–brain barrier permeability and exudation from inflamed meninges. Glucose is typically low because of impaired transport and consumption by inflammatory cells/mycobacteria. A purulent, neutrophil-predominant CSF pattern is more typical of acute pyogenic bacterial meningitis, while RBC predominance suggests hemorrhage/traumatic tap rather than TB.
Pathological jaundice appears—?
- After 3 days of birth
- Within the first 24 hours
- After 1 week
- After 2 weeks
Explanation: Answer reason: Very early onset suggests hemolysis (e.g., Rh/ABO incompatibility, G6PD deficiency), infection, or other significant pathology causing rapid bilirubin rise. This timing is a key discriminator used clinically to triage newborns for urgent bilirubin measurement and evaluation to prevent bilirubin neurotoxicity. In contrast, jaundice starting after the first day and peaking around days 3–5 is more consistent with physiologic jaundice in many term infants.
Necrosis is defined as?
- Programmed cell death
- Unregulated cell death due to injury
- Cell adaptation
- Cell proliferation
Explanation: Answer reason: This matches unregulated death from insults such as ischemia, toxins, infection, or trauma. In contrast, programmed cell death refers to apoptosis, which is energy-dependent, regulated, and typically does not elicit inflammation. The remaining options describe non-lethal cellular responses (adaptation) or increased cell number (proliferation), not cell death.
Risk of kernicterus increases when bilirubin is—?
- <10 mg/dL
- 10–12 mg/dL
- >20 mg/dL
- Normal
Explanation: Answer reason: The risk rises sharply at very high total serum bilirubin levels, classically around or above 20 mg/dL, especially when additional risk factors (prematurity, hemolysis, low albumin, acidosis) reduce bilirubin binding. The lower ranges listed are more consistent with mild-to-moderate physiologic jaundice and do not typically correlate with bilirubin encephalopathy in otherwise stable term infants. Therefore the threshold given in this option best matches the level associated with increased kernicterus risk.
First-line treatment of neonatal jaundice is—?
- Exchange transfusion
- Phototherapy
- Surgery
- Antibiotics
Explanation: Answer reason: Unconjugated hyperbilirubinemia in newborns is most commonly physiologic and is managed first by enhancing bilirubin breakdown and clearance to prevent kernicterus. Phototherapy converts bilirubin into water-soluble photoisomers that can be excreted in bile and urine without hepatic conjugation. This makes it an effective, noninvasive initial therapy for the majority of neonatal jaundice cases. Exchange transfusion is reserved for severe or rapidly rising bilirubin or failure of intensive phototherapy, while antibiotics are only indicated if jaundice is due to suspected infection and do not directly treat bilirubin elevation.
Jaundice appearing within 24 hours is considered—?
- Physiological
- Pathological
- Mild
- Self-limiting
Explanation: Answer reason: Very early onset suggests an underlying disease process such as hemolysis (e.g., Rh/ABO incompatibility, G6PD deficiency), infection, or other causes of excessive bilirubin load. This timing implies a higher risk of rapidly rising unconjugated bilirubin and bilirubin neurotoxicity, requiring prompt evaluation and treatment. By contrast, physiologic jaundice usually peaks later (around days 3–5) and resolves as hepatic clearance improves. Therefore, jaundice within 24 hours is classified as abnormal rather than benign or self-limited.
Gangrene is best defined as?
- Localized apoptosis
- Death of tissue with putrefaction
- Inflammation of tissue
- Scar formation
Explanation: Answer reason: The presence of putrefaction (foul-smelling breakdown) reflects bacterial activity and autolysis in devitalized tissue, classically seen in wet gangrene. Apoptosis is a regulated, non-inflammatory programmed cell death and does not produce putrefactive changes. Inflammation and scar formation can be associated sequelae of injury, but they are not defining features of gangrene.
Coagulative necrosis is most commonly seen in?
- Brain
- Heart (myocardial infarction)
- Pancreas
- Lung abscess
Explanation: Answer reason: Ischemia in most solid organs denatures structural proteins and enzymes, preserving tissue architecture initially, which defines coagulative necrosis. Myocardial infarction is a classic setting because coronary occlusion causes acute ischemia of cardiac muscle with this necrosis pattern. In contrast, the brain typically undergoes liquefactive necrosis after ischemic injury due to high lipid content and enzymatic digestion. The pancreas is associated with enzymatic fat necrosis (e.g., acute pancreatitis), and lung abscesses characteristically show liquefactive necrosis from suppurative infection.
Most common symptom of meningitis in infants is?
- Neck stiffness
- Bulging fontanelle
- Petechial rash
- Convulsion
Explanation: Answer reason: Meningeal inflammation can raise intracranial pressure, which is more readily appreciated in infants as a full or bulging anterior fontanelle. Neck stiffness is more characteristic in older patients, while petechial rash is suggestive of meningococcemia rather than being the most common general presentation of meningitis. Seizures can occur but are less common than the nonspecific early signs that reflect increased intracranial pressure and systemic illness.
Neonatal jaundice is caused by—?
- Infection
- Increased bilirubin in blood
- Low hemoglobin
- Low blood sugar
Explanation: Answer reason: Elevated unconjugated bilirubin deposits in the skin and sclera, producing the characteristic yellow discoloration. This mechanism is the direct pathophysiologic cause being tested, not an associated trigger or complication. Infection can contribute to jaundice in some cases, but it is not the fundamental definition or primary cause across neonatal jaundice presentations. Low hemoglobin and low blood sugar are not causal mechanisms for bilirubin accumulation.
Karyolysis means?
- Dissolution of nucleus
- Condensation of nucleus
- Fragmentation of nucleus
- Swelling of cell
Explanation: Answer reason: This produces progressive dissolution and eventual disappearance of the nucleus on histology, classically seen in necrosis. In contrast, condensation of the nucleus describes pyknosis, and fragmentation of the nucleus describes karyorrhexis. Cell swelling is an early, potentially reversible change and is not a nuclear pattern.
The most common cause of necrosis is?
- Infection
- Ischemia (loss of blood supply)
- Autoimmunity
- Vitamin deficiency
Explanation: Answer reason: Reduced blood flow also limits nutrient delivery and waste removal, amplifying cellular damage and promoting coagulative necrosis in many tissues. Infections and immune-mediated injury can cause necrosis, but they are less frequent overall compared with ischemic injury across common clinical contexts such as infarction. Vitamin deficiencies primarily cause functional impairment and specific deficiency syndromes rather than being the predominant mechanism of widespread tissue necrosis.
The classical histological feature of necrosis is?
- Karyolysis, Pyknosis, Karyorrhexis
- Cell proliferation
- Fat deposition
- Apoptotic bodies
Explanation: Answer reason: The progression includes pyknosis (nuclear shrinkage and hyperchromasia), karyorrhexis (nuclear fragmentation), and karyolysis (fading/disappearance of the nucleus). These findings reflect cell death with membrane breakdown and inflammation rather than regeneration. Apoptotic bodies are typical of apoptosis, which is programmed cell death with preserved membranes and minimal inflammation, making it a key distractor here.
Schizophrenia causes ?
- Hallucination
- Hairfall
- Diarrhea
- Acne
Explanation: Answer reason: g., hallucinations, delusions), disorganized thinking/behavior, and negative symptoms. Hallucinations—most commonly auditory—are a hallmark symptom and reflect impaired reality testing. The other options are nonspecific physical complaints and are not defining clinical features of schizophrenia (though they may occur for unrelated reasons or as medication side effects). Therefore the option that best matches a core manifestation of schizophrenia is the one describing hallucinations.
The nurse is admitting an eight year old patient with the following signs/ symptoms: strawberry red tongue, red palms, and a high fever. The nurse understands these are likely signs of which disease?
- Cystic fibrosis
- Kawasaki disease
- Rheumatic fever
- Sickle cell anemia
Explanation: Answer reason: A “strawberry tongue” and erythema of the palms are classic mucous membrane and peripheral findings that point toward this diagnosis. Identifying it matters because untreated disease can cause coronary artery aneurysms, so early recognition supports timely therapy (e.g., IVIG and aspirin). Rheumatic fever can follow streptococcal infection with migratory arthritis and carditis but does not typically cause prominent red palms with this mucocutaneous pattern. Cystic fibrosis and sickle cell anemia do not produce this specific combination of fever with strawberry tongue and palmar erythema.
The nurse provides a teaching session to the nursing staff regarding osteosarcoma. Which statement by a member of the nursing staff indicates a need for information?
- The femur is the most common site of this sarcoma
- The child does not experience pain at the primary tumor site.
- Limping, if a weight-bearing limb is affected, is a clinical manifestation.
- The symptoms of the disease in the early stage are almost always attributed to normal growing pains.
Explanation: Answer reason: Osteosarcoma typically presents with localized bone pain that may be intermittent at first and then becomes persistent, often worsening at night or with activity. This pain is a key early symptom and is frequently mistaken for sports injury or “growing pains,” contributing to delayed evaluation. Limping can occur when a weight-bearing bone is involved due to pain and decreased function. Therefore, stating that the child does not have pain at the primary tumor site reflects incorrect understanding and indicates need for further teaching.
Nurse Lily is assessing a male client diagnosed with gonorrhea. Which symptom most likely prompted the client to seek medical attention?
- Rashes on the palms of the hands and soles of the feet.
- Cauliflower-like warts on the penis.
- Painful red papules on the shaft of the penis.
- Foul-smelling discharge from the penis
Explanation: Answer reason: Gonorrhea most commonly causes acute urethritis in males, with urethral irritation and purulent penile discharge that is noticeable and prompts care-seeking. This discharge results from neutrophil-rich exudate due to mucosal infection by Neisseria gonorrhoeae. In contrast, rashes on palms/soles are characteristic of secondary syphilis, and cauliflower-like warts are typical of HPV genital warts. Painful papules on the shaft suggest herpes or other dermatoses rather than gonococcal urethritis.
Which of the following definitions best describes gastritis?
- Erosion of the gastric mucosa.
- Inflammation of a diverticulum.
- Inflammation of the gastric mucosa.
- Reflux of stomach acid into the esophagus.
Explanation: Answer reason: Gastritis is defined by inflammation of the stomach lining, which may be acute (often irritant- or infection-related) or chronic (e.g., autoimmune or H. pylori-associated). This directly matches the concept of mucosal inflammatory change rather than a structural breakdown alone. Erosion of the mucosa is more consistent with erosive gastritis or peptic ulcer disease terminology, not the core definition. Acid reflux into the esophagus describes GERD, and inflammation of a diverticulum refers to diverticulitis in the colon.
The classic symptoms that define breast cancer includes the following except?
- Solitary, irregularly shaped mass
- “Pink peel” skin
- Firm, nontender, nonmobile mass
- Abnormal discharge from the nipple
Explanation: Answer reason: Skin changes associated with malignancy are typically described as “peau d’orange” (orange-peel dimpling) from lymphatic obstruction, not “pink peel.” A solitary irregular mass and a firm, nontender, nonmobile mass are hallmark suspicious findings on exam. “Pink” skin changes more strongly suggest inflammatory processes (e.g., mastitis/inflammatory breast cancer described as erythema and warmth) rather than a classic defining symptom phrased this way.
What information is correct about stomach cancer?
- Stomach pain is often a late symptom.
- Surgery is often a successful treatment.
- Chemotherapy and radiation are often successful treatments.
- The patient can survive for an extended time with TPN.
Explanation: Answer reason: Gastric cancer classically has vague, nonspecific early manifestations (e.g., dyspepsia, early satiety, anorexia, weight loss), so patients frequently present late in the disease course. Pain tends to appear when there is deeper wall invasion, obstruction, or metastatic involvement, making it a later finding rather than an early, reliable warning sign. Curative outcomes from surgery are not “often” achieved because many cases are diagnosed at an advanced stage, limiting resectability. Chemo-radiation may be used perioperatively or palliatively but is not typically described as “often successful” in a broad sense, and TPN supports nutrition without treating the malignancy or substantially extending survival by itself.
The nurse is caring for a client who is receiving a chemotherapy. Which of the following would be expected as a result of the massive cell destruction that occurred from the chemotherapy?
- Leukopenia
- Anemia
- Thrombocytopenia
- Hyperuricemia
Explanation: Answer reason: This can precipitate uric acid crystals in renal tubules, increasing risk for acute kidney injury and related electrolyte disturbances. The other options reflect bone marrow suppression from chemotherapy, which is common but is not the key consequence specifically tied to “massive cell destruction.” Therefore the expected result of rapid cell breakdown is elevated uric acid levels.
You are taking the history of a 14-year-old girl who has a BMI of 18. The girl reports an inability to eat, induced vomiting, and severe constipation. Which of the following would you most likely suspect?
- Multiple sclerosis
- Anorexia nervosa
- Bulimia
- Systemic sclerosis
Explanation: Answer reason: Self-induced vomiting is a classic compensatory behavior pointing to bulimia nervosa, and constipation can occur from dehydration, electrolyte disturbances, and disordered eating patterns. A BMI of 18 may be low-normal/underweight but does not exclude bulimia, whereas anorexia nervosa typically features prominent restriction with significantly low body weight as a defining feature. Neurologic (multiple sclerosis) and connective-tissue (systemic sclerosis) disorders do not primarily present with intentional vomiting for weight control.
On assessment of a child admitted with a diagnosis of acute-stage Kawasaki disease, the nurse expects to note which clinical manifestation of the acute stage of the disease?
- Cracked lips
- Normal appearance
- Conjunctival hyperemia
- Desquamation of the skin
Explanation: Answer reason: This finding reflects the systemic medium-vessel vasculitis and is expected early in the illness along with oral mucosal changes and rash. Skin desquamation is more characteristic of the subacute/convalescent phase (often periungual peeling after the acute fever begins to resolve), making it less fitting for “acute-stage.” “Normal appearance” is inconsistent with an acute inflammatory vasculitis syndrome.
A 24-year-old female is admitted to the emergency room for confusion. The patient has a history of multiple myeloma, constipation, intense abdominal pain, and polyuria. Which of the following would you most likely suspect?
- Diverticulosis
- Hypercalcemia
- Hypocalcemia
- Irritable bowel syndrome
Explanation: Answer reason: The symptom cluster of confusion, constipation, abdominal pain, and polyuria is classic for elevated serum calcium due to neurocognitive depression, decreased GI motility, and nephrogenic diabetes insipidus-like effects. Hypocalcemia would more typically present with neuromuscular irritability (e.g., tetany, paresthesias, seizures) rather than constipation and polyuria. Diverticulosis or IBS can cause abdominal discomfort and bowel changes but do not explain the prominent polyuria and acute mental status changes in the context of myeloma.
The pathological process causing esophageal varices is/are?
- Ascites and edema
- Systemic hypertension
- Portal hypertension
- Dilated veins and varicosities
Explanation: Answer reason: This chronic high-pressure flow causes progressive venous dilation and tortuosity, creating fragile varices prone to massive bleeding. Systemic arterial hypertension does not raise portal venous pressure and therefore is not the primary driver of this complication. Ascites/edema are common consequences of portal hypertension and liver dysfunction, while dilated veins are the anatomic result rather than the underlying pathologic process.
A client was admitted to the hospital due to pain and inflammation that were not relieved by rest. Which of the following statements by the client would demonstrate a correct understanding of the disease process of rheumatoid arthritis?
- This pain is just from overusing my joints, and it will go away if I rest enough.
- Rheumatoid arthritis is the same as osteoarthritis, just a different name.
- I don't need to take my medications unless I'm in pain.
- Rheumatoid arthritis is an autoimmune disease where my immune system mistakenly attacks my joints, causing inflammation and pain.
Explanation: Answer reason: Rheumatoid arthritis is a systemic autoimmune inflammatory disorder driven by immune-mediated synovitis, leading to joint swelling, pain, and progressive damage. This statement accurately explains the underlying mechanism (immune system attacking joint tissues) and why symptoms persist despite rest. In contrast, overuse-related pain and osteoarthritis are primarily degenerative/mechanical processes and are typically more relieved by rest and activity modification. RA therapy also targets ongoing inflammation and immune activity, so management is not based solely on whether pain is present at a given moment.
Which of the following statements is true concerning the risk factors for breast cancer?
- Hormones are not a risk factor for breast cancer.
- Other types of cancer history have no correlation with breast cancer.
- Ethnicity is a risk factor.
- Environment is not a risk factor for breast cancer.
Explanation: Answer reason: Breast cancer risk is influenced by nonmodifiable epidemiologic factors, including demographic background, as incidence varies across populations due to genetic susceptibility patterns and differing baseline risks. This makes the statement about ethnicity a true risk-factor concept. In contrast, hormonal exposure is a well-established contributor (e.g., prolonged estrogen exposure), so denying hormones as a risk factor is incorrect. Environmental and lifestyle-related exposures can also affect risk, so stating the environment is not a risk factor is inaccurate. Prior malignancy and shared genetic syndromes can correlate with breast cancer risk in some contexts, making the absolute “no correlation” claim unsafe.
When observıng a newborn wıth down syndrome Which of the following assessment finding evaluation from the nurse?
- Simian crease
- Brow sweating during feeding
- Small rounded skull
- Hypotonic muscles
Explanation: Answer reason: A single transverse palmar crease is a classic, commonly tested feature and directly fits the question’s focus on expected findings. Hypotonia is also common, but the item asks for the best assessment finding to evaluate, and the palmar crease is a more specific dysmorphic marker in typical exam framing. Brow sweating during feeding more strongly suggests increased cardiac workload (e.g., congenital heart disease/heart failure) rather than a defining phenotypic sign of the syndrome.
A hospitalized patient has a history of gout. The nurse knows that this is a type of arthritis that occurs due to the accumulation of what substance in the blood?
- Creatinine
- Lactic acid
- Tyramine
- Uric acid
Explanation: Answer reason: Elevated serum urate promotes crystal formation, which triggers intense neutrophil-mediated inflammation and acute joint pain/swelling. Creatinine is primarily a marker of renal filtration rather than a direct cause of crystal arthropathy. Lactic acid can contribute to reduced urate excretion during lactic acidosis, but it is not the deposited substance responsible for gouty arthritis.
A patient with Chagas disease (kissing bug disease) has eyelid swelling. This is known as?
- Cullen’s Sign
- Romaña’s Sign
- Goodell’s Sign
- Chvostek’s Sign
Explanation: Answer reason: This finding is specifically associated with Chagas disease and supports the diagnosis in the acute phase. Cullen’s sign is periumbilical ecchymosis related to intra-abdominal bleeding (e.g., pancreatitis), not an eye finding. Goodell’s sign indicates cervical softening in pregnancy, and Chvostek’s sign reflects neuromuscular irritability from hypocalcemia.
The Hodgkin’s disease patient described in the question above undergoes a lymph node biopsy for definitive diagnosis. If the diagnosis of Hodgkin’s disease were correct, which of the following cells would the pathologist expect to find?
- Reed-Sternberg cells.
- Lymphoblastic cells.
- Gaucher's cells.
- Rieder's cells
Explanation: Answer reason: Hodgkin lymphoma is defined histologically by the presence of malignant Reed–Sternberg cells within an inflammatory background on lymph node biopsy. These large atypical B cells (often described as “owl-eye” nuclei) are the diagnostic hallmark and distinguish Hodgkin lymphoma from most non-Hodgkin processes. Lymphoblastic cells are more characteristic of acute lymphoblastic leukemia/lymphoblastic lymphoma rather than Hodgkin lymphoma. Gaucher cells indicate a lysosomal storage disorder, and Rieder cells are not the defining diagnostic cell for Hodgkin lymphoma.
A female client went to the emergency department states that she is having burning and intense itching on the skin. A further assessment made by the nurse notes that the client is having red and white patches in the mouth. Based on this, the nurse understand that the client is most likely is suffering from?
- Shingles
- Erysipelas
- Eczema
- Candidiasis
Explanation: Answer reason: Oral thrush classically presents as erythematous mucosa with white plaques and is commonly due to Candida species. This constellation is not typical of shingles, which is a painful unilateral dermatomal vesicular eruption, nor erysipelas, which causes a sharply demarcated bacterial cellulitis with systemic signs. Eczema can cause pruritus and inflammation but does not characteristically produce oral white patches consistent with thrush.
A 3-year-old girl is brought to the physician because of fever. The mother reports that she has had fevers every day for a week despite regular doses of acetaminophen. The child has been lethargic and has diminished appetite. Her temperature is 39.0°C (102.2°F), pulse is 130/min, and respirations are 40/min. Physical examination shows bilateral nonexudative conjunctivitis sparing the limbus. Her lips are cracked, and her tongue is red and swollen. The posterior pharynx is erythematous without exudate. Tympanic membranes are mildly erythematous with normal mobility bilaterally. She has multiple bilateral tender cervical lymph nodes. Her lungs are clear and abdomen is diffusely mildly tender without masses. She has a desquamating rash on her trunk and her hands and feet are swollen and tender. What is the best treatment for this child's condition?
- Acetaminophen, good hydration, and observation
- Amoxicillin
- Ibuprofen, good hydration, and observation
- IVIG and high-dose aspirin
- Oseltamivir and isolation from other children
Explanation: Answer reason: The main treatment goal is preventing coronary artery aneurysms and thrombosis from the medium-vessel vasculitis. IV immunoglobulin given early markedly reduces coronary complications, and high-dose aspirin is used for anti-inflammatory and then antiplatelet effect during the acute/subacute phases. Supportive care alone or antibiotics/antivirals would not address the vasculitic process or reduce cardiac risk.
A client’s angiogram demonstrates the final stage of atherosclerosis. The nurse concludes that this client’s pathophysiology includes which late-developing element?
- Presence of atheromas
- Fatty deposits in the intima
- Lipoprotein accumulation in the intima
- Inflammation of the arterial wall
Explanation: Answer reason: The late stage is characterized by mature atheromatous plaques (atheromas) with a lipid-rich necrotic core and a fibrous cap that significantly narrows the arterial lumen and can rupture. The other choices describe earlier steps in lesion initiation and propagation rather than the late, fully developed lesion seen in advanced disease. Angiographic “final stage” implies substantial plaque burden producing fixed stenosis consistent with established atheroma.
A new mother has some questions about phenylketonuria (PKU). Which of the following statements made by a nurse is not correct regarding PKU?
- A Guthrie test can check the necessary lab values.
- The urine has a high concentration of phenylpyruvic acid.
- Mental deficits are often present with PKU.
- The effects of PKU are reversible.
Explanation: Answer reason: Untreated PKU causes neurotoxicity from elevated phenylalanine and its metabolites, leading to progressive and often permanent intellectual disability. Early newborn screening (e.g., Guthrie test) and prompt dietary phenylalanine restriction prevent neurologic injury, but they do not reliably undo damage already sustained. The presence of phenylpyruvic acid in urine and potential mental deficits are classic findings/risks that support the diagnosis and consequences. Therefore, claiming the effects are reversible is the inaccurate statement.
The client with which of the following types of lung cancer has the best prognosis?
- Adenocarcinoma
- Oat cell
- Squamous cell
- Small cell
Explanation: Answer reason: This type is more often peripheral and may present as a solitary lesion amenable to surgical resection, which improves survival compared with more aggressive neuroendocrine subtypes. Small cell (including “oat cell”) is typically rapidly proliferative, strongly associated with early metastasis, and is therefore treated primarily with systemic therapy rather than curative surgery, leading to a worse overall prognosis. Squamous cell can be localized but is commonly central and associated with complications (e.g., obstruction) and overall does not outperform the more frequently resectable peripheral pattern described above. Overall, the relative tendency toward earlier-stage diagnosis and operability supports the best prognosis among the listed options.
The third period of infectious processes characterized by development of specific signs and symptoms?
- Incubation period
- Prodromal period
- Illness period
- Convalescent period
Explanation: Answer reason: The stage where characteristic, disease-specific signs and symptoms are fully developed is the illness period, reflecting peak pathogen activity and host inflammatory response. This is when clinical findings best match a recognizable syndrome and diagnosis is most apparent. Convalescence follows as symptoms resolve and the patient returns toward baseline function.
A goal of medical treatment for patients with cirrhosis is to prevent complications and limit cell damage. A major approach is to promote rest. What rationale supports this approach?
- Allows time for a transplant
- Allows the liver to regenerate
- Prevents red cell destruction
- Decreases the risk of trauma
Explanation: Answer reason: By lowering energy expenditure and oxygen requirements, rest supports hepatocyte recovery and whatever regenerative capacity remains despite cirrhotic scarring. This directly aligns with the treatment goal of limiting ongoing cell damage and preventing decompensation. Options about transplant timing or red cell destruction do not explain the physiologic benefit of rest in cirrhosis, and trauma prevention is not the primary rationale for prescribing rest in this context.
A client is admitted to the ER for head trauma is diagnosed with an epidural hematoma. The underlying cause of epidural hematoma is usually related to which of the following conditions?
- Laceration of the middle meningeal artery
- Rupture of the carotid artery
- Thromboembolism from a carotid artery
- Venous bleeding from the arachnoid space
Explanation: Answer reason: The middle meningeal artery runs in grooves of the temporal bone and is prone to tearing with blunt head trauma, producing a rapidly expanding hematoma and possible lucid interval. Carotid rupture is not the typical mechanism for an epidural collection and would more commonly cause different intracranial bleeding patterns or catastrophic hemorrhage. Venous bleeding is more characteristic of subdural hematoma from bridging vein rupture rather than epidural bleeding.
A pregnant woman arrives at the emergency department (ED) with abruptio placentae at 34 weeks' gestation. She's at risk for which of the following blood dyscrasias?
- Heparin-associated thrombosis and thrombocytopenia (HATT)
- Idiopathic thrombocytopenic purpura (ITP)
- Thrombocytopenia
- Disseminated intravascular coagulation (DIC)
Explanation: Answer reason: Abruptio placentae can release large amounts of thromboplastin from damaged placental/decidual tissue into the maternal circulation, triggering widespread activation of the coagulation cascade. This causes consumption of platelets and clotting factors with secondary fibrinolysis, producing a classic consumption coagulopathy with bleeding risk. That mechanism specifically matches DIC rather than isolated thrombocytopenia, which does not explain the factor consumption and systemic microthrombi formation. HATT requires heparin exposure with immune-mediated platelet activation, and ITP is an autoimmune platelet destruction process not specifically precipitated by placental abruption.
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