Infection Control Practice Test 10
Infection Control NCLEX Practice Test
Infection Control is a key topic within the NCLEX test plan, located under Safe and Effective Care Environment → Safety and Infection Control → Infection Control. This section focuses on asepsis, transmission precautions, and infection prevention across all clinical settings. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 10th part of the Infection Control series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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In the Infection Control Study Cards section, shared by real NCLEX candidates, you’ll find concise summaries and high-yield insights related to the most tested concepts. It’s a perfect space to reinforce challenging topics and sharpen your recall through quick, focused repetitions. Short, powerful, and repeatable!
Infection Control Practice Test 10
The nurse in the intensive care unit (ICU) is giving unlicensed assistive personnel (UAP) directions for bathing a client who has a surgical incision infected with methicillin-resistant Staphylococcus aureus (MRSA). Which instructions would be most effective for reducing infection?
- Assist the client to the shower and provide directions to use antibacterial soap
- Delay the bath until the client has received antibiotic therapy for 24 hours
- Use a bath basin with warm water and a new wash cloth for each body area
- Use packaged pre-moistened cloths containing chlorhexidine to bathe the client
Explanation: Answer reason: Prepackaged CHG cloths also standardize technique and avoid contamination risks associated with reusable basins that can harbor pathogens and spread them between patients. Showering with “antibacterial soap” is less reliable and may not provide the sustained antimicrobial effect of CHG. Waiting for antibiotics delays hygiene and does not address contact spread from skin colonization, which is a key infection-control target.
A nurse manager is planning an in-service for a group of nurses about caring for clients following stem cell transplants. Which of the following instructions should the nurse manager include in the teaching?
- Assign two clients who have had a stem cell transplant to the same room.
- Obtain a rectal temperature on clients every 4 hr.
- Wear an N95 respirator mask while caring for these clients.
- Place clients in positive-pressure airflow rooms.
Explanation: Answer reason: Protective (reverse) isolation is the key principle after stem cell transplant because profound neutropenia makes the client highly susceptible to airborne and environmental pathogens. Positive-pressure rooms reduce entry of unfiltered corridor air and help prevent exposure to organisms such as fungal spores. Rectal temperatures should be avoided due to risk of mucosal injury and bacteremia in immunocompromised clients. Routine N95 use is not required unless the client is on airborne precautions for a specific infection; the priority is environmental protection and strict infection-control measures.
The nurse is preparing a continuous intravenous (IV) infusion at the medication cart. As the nurse goes to insert the spike end of the IV tubing into the IV bag, the tubing drops and the spike end hits the top of the medication cart. The nurse should take which action?
- Obtain a new IV bag.
- Obtain new IV tubing.
- Wipe the spike end of the tubing with povidone iodine.
- Scrub the spike end of the tubing with an alcohol swab.
Explanation: Answer reason: Maintaining sterility of the IV administration set is a core infection-control principle because any contamination of the spike can directly introduce microorganisms into the IV fluid pathway and bloodstream. Once the spike touches a nonsterile surface, it is considered contaminated and cannot be reliably re-sterilized at the bedside with wipes or swabs. Replacing the tubing removes the contaminated component and restores a sterile infusion setup. Replacing the IV bag is unnecessary because the bag has not been breached, and antiseptics on the spike risk incomplete decontamination and introducing chemical residue into the system.
A burn client's care plan reveals an expected outcome of no localized or systemic infection. Which assessment by the nurse supports this outcome?
- Wound culture results that show minimal bacteria
- Cloudy, foul-smelling urine output
- White blood cell count of 14,000
- Temperature of 101°F
Explanation: Answer reason: A culture showing minimal bacteria indicates no significant local colonization progressing toward invasive infection. The other findings suggest infection: cloudy, foul-smelling urine points to a UTI, a WBC of 14,000 indicates leukocytosis, and a temperature of 101°F indicates fever and possible systemic involvement. Therefore, the culture result is the assessment most consistent with the expected outcome.
The nurse plans to collect a urine specimen from a client with an indwelling urinary catheter. Which action does the nurse take?
- Clamp the drainage tubing below the aspiration port.
- Disconnect the catheter from drainage tubing to obtain the specimen.
- Insert a 21G needle into the shaft of the catheter tubing.
- Irrigate the catheter prior to collecting the specimen.
Explanation: Answer reason: Urine specimens from an indwelling catheter should be collected from the designated sampling (aspiration) port using aseptic technique to minimize CAUTI risk and to avoid contaminating the closed drainage system. Clamping the tubing distal to the sampling port allows fresh urine to pool in the tubing/bladder segment so an adequate, current sample can be withdrawn. Disconnecting the catheter from the drainage tubing breaks the closed system and increases infection risk. Inserting a needle into the tubing can create leaks and introduces contamination, and irrigating before collection dilutes the sample and can alter culture/urinalysis results unless specifically prescribed.
A client who has been diagnosed with possible avian influenza is admitted to the medical unit. Which prescribed action will the nurse take first?
- Place the client in an airborne isolation room.
- Initiate infusion of 500 mL of normal saline bolus.
- Ask the client about any recent travel to Asia.
- Obtain sputum specimen and nasal cultures.
Explanation: Answer reason: The core priority with suspected avian influenza is immediate transmission prevention because it is a potentially severe respiratory infection with risk of spread in a healthcare setting. Implementing appropriate isolation is a time-critical nursing action that protects other patients and staff before additional assessments or procedures increase exposure. Diagnostic cultures can be obtained after precautions are in place to reduce aerosol/droplet generation risk during specimen collection. A fluid bolus is only first if there is evidence of hemodynamic instability, which is not provided in the stem.
The home health nurse teaches a client how to procure a clean-catch urine specimen. Which statement indicates that the client understands the nurse’s instructions?
- “I will keep the collection bottle in an ice-filled cooler.”
- “I will strain my urine and empty the nephroliths into the specimen bag.”
- “I need to don sterile gloves, clean myself with iodine solution, and then collect a sterile specimen.”
- “I will urinate a small amount into the toilet and collect the remaining sample in a clean collection cup.”
Explanation: Answer reason: A clean-catch (midstream) urine specimen is collected by voiding the initial urine stream to flush urethral contaminants, then collecting the midstream portion in a clean container to reduce false contamination. This statement correctly describes discarding the first small amount and then collecting the remaining midstream sample. Keeping a bottle on ice is not part of the collection technique being taught and relates more to specimen preservation after collection. Using sterile gloves/iodine and calling it a sterile specimen describes a sterile collection (or an overly sterile technique) rather than the standard clean-catch method taught to most clients at home.
A home health nurse is planning care for a client who is receiving chemotherapy and has neutropenia. Which of the following foods should the nurse include in the client's plan of care?
- Soft-boiled eggs
- Raw carrots
- Spinach salad
- Baked chicken
Explanation: Answer reason: A fully cooked poultry dish fits this principle because heat reduces bacterial load and makes the food safer. Soft-boiled eggs are often undercooked and can harbor Salmonella, and raw vegetables/leafy salads can carry pathogens that are difficult to eliminate even with washing. Therefore, the safest choice among the options is the fully cooked entrée.
A mother has heard that several children have been diagnosed with mononucleosis. She asks the nurse what precautions should be taken to prevent this from occurring in her child. The nurse should instruct the mother to?
- Take no particular precautionary measures.
- Sterilize the child's eating utensils before they are reused.
- Wash the child's linens separately in hot, soapy water.
- Wear masks when providing direct personal care.
Explanation: Answer reason: Infectious mononucleosis (typically EBV) is primarily transmitted through saliva with close personal contact, and it is not effectively prevented by routine household sterilization or special laundry practices. Standard hygiene (handwashing, avoiding sharing drinks/utensils when someone is ill) is reasonable, but there are no specific isolation-type precautions recommended for healthy children in the community to prevent acquisition. Sterilizing utensils and separating linens suggest fomite or contact-spread control measures that are not central to EBV transmission. Mask use is aimed at droplet/airborne pathogens and is not indicated for typical mono exposure in the home/community setting.
The color of bag in which the infectious solids wastes are disposed?
- Red
- Black
- Blue
- Yellow
Explanation: Answer reason: Infectious solid waste (soiled items contaminated with blood/body fluids) is placed in designated biohazard bags intended for contaminated solids, which are commonly red. This directs staff to apply appropriate precautions and ensures correct downstream treatment (e.g., disinfection/incineration) for infectious material. Black is generally reserved for non-infectious/general waste, while blue and yellow are typically used for other specific waste streams depending on local policy, making them less appropriate for infectious solids here.
A client receiving parenteral nutrition (PN) suddenly develops a fever. The nurse notifies the health care provider (HCP), and the HCP initially prescribes that the solution and tubing be changed. What should the nurse do with the discontinued materials?
- Discard them in the unit trash.
- Return them to the hospital pharmacy.
- Save them for return to the manufacturer.
- Prepare to send them to the laboratory for culture.
Explanation: Answer reason: Fever in a client on PN raises concern for catheter-related bloodstream infection or contaminated PN solution, so potential sources should be cultured to guide targeted therapy. Sending the discontinued solution and tubing for culture preserves evidence of contamination and supports appropriate antimicrobial selection and infection-control actions. Discarding them removes the opportunity to identify the organism and source. Returning to pharmacy/manufacturer does not address the immediate clinical need to evaluate infection risk and manage the patient safely.
The nurse is caring for a client with a diagnosis of breast cancer who is immunosuppressed. The nurse would consider implementing neutropenic precautions if the client's white blood cell count was which value?
- 2000 mm3 (2.0 × 10^9/L)
- 5800 mm3 (5.8 × 10^9/L)
- 8400 mm3 (8.4 × 10^9/L)
- 11,500 mm3 (11.5 × 10^9/L)
Explanation: Answer reason: 2000 mm3 (2.0 × 10^9/L) Neutropenic precautions are implemented when the patient’s infection risk is high due to markedly reduced leukocyte/particularly neutrophil availability, most commonly reflected by very low WBC/ANC in oncology patients. A WBC of 2000/mm3 indicates significant leukopenia and strongly suggests a potentially dangerously low absolute neutrophil count, warranting protective measures (strict hand hygiene, avoiding sick contacts, limiting raw foods/flowers per policy, monitoring for fever). Values like 5800/mm3 and 8400/mm3 are within typical adult reference ranges and do not indicate neutropenia by themselves. Although 11,500/mm3 may indicate inflammation or stress leukocytosis, it does not signal immunosuppression requiring neutropenic precautions.
The nurse is assigned to care for an infant on the first postoperative day after a surgical repair of a cleft lip. Which nursing intervention is appropriate when caring for this child's surgical incision?
- Rinsing the incision with sterile water after feeding
- Cleaning the incision only when serous exudate forms
- Rubbing the incision gently with a sterile cotton-tipped swab
- Replacing the Logan bar carefully after cleaning the incision
Explanation: Answer reason: Gentle rinsing with sterile water after feeds helps keep the incision clean without applying friction or pressure that could disrupt the repair. Waiting to clean until drainage appears is reactive and allows residue to remain in place, increasing risk of crusting and infection. Direct rubbing with a swab can traumatize the delicate suture line and precipitate bleeding or dehiscence. Keeping the Logan bar in place is important, but the key appropriate routine incision-care action immediately after feeds is cleansing/rinsing to remove contaminants.
Anurag is put on a femoral venous catheter in a hospital. What should a nurse to while caring for Anurag-?
- Irrigate the catheter with sterile saline solution to retain patency
- Maintain sterility when working with the catheter
- Evaluate the pressure dressing frequently for bleeding
- Limit the mobility of the affected limb
Explanation: Answer reason: Using sterile technique for hub access, dressing changes, and line manipulation reduces contamination and subsequent sepsis risk. Routine irrigation/flushes are not universally indicated unless prescribed and can introduce organisms or cause complications if done improperly. While monitoring for bleeding and limiting hip flexion/movement can be helpful with femoral sites, infection prevention remains the highest-priority, always-applicable intervention.
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