Infection Control Practice Test 2
Infection Control NCLEX Practice Test
Infection Control is a key topic within the NCLEX test plan, located under Safe and Effective Care Environment → Safety and Infection Control → Infection Control. This section focuses on asepsis, transmission precautions, and infection prevention across all clinical settings. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 2nd part of the Infection Control series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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In the Infection Control Study Cards section, shared by real NCLEX candidates, you’ll find concise summaries and high-yield insights related to the most tested concepts. It’s a perfect space to reinforce challenging topics and sharpen your recall through quick, focused repetitions. Short, powerful, and repeatable!
Infection Control Practice Test 2
What is the most important principle in bag technique during a home visit in public health nursing?
- Should save time & effort
- Should minimize if not totally prevent spread of infection
- Should not overshadow concern for patient and his family
- May be done in variety of ways depending on home situation, etc.
Explanation: Answer reason: The primary objective of bag technique in community/home visits is to prevent cross-contamination; minimizing the spread of infection is the most important principle.
What is the most important client teaching for a client with inflammatory arthritis who takes prednisone and is scheduled for elective surgery?
- The purpose of coughing and deep breathing after anesthesia.
- The resources that are available to assist with care after discharge.
- The signs and symptoms that indicate the development of infection.
- The explanation of a precise schedule for stopping steroid medication.
Explanation: Answer reason: Chronic prednisone suppresses immune response and can mask infection, increasing postoperative infection risk. Teaching to recognize infection signs is the highest priority for safety.
What action should the nurse take when a visitor brings a potted plant to a client with neutropenia in the oncology unit?
- Allow the client to keep the plant.
- Place the plant by the window.
- Water the plant for the client.
- Ask the family to take the plant home.
Explanation: Answer reason: Clients with neutropenia require protective precautions; soil and standing water in potted plants harbor bacteria and fungi (e.g., Aspergillus) that can cause serious infection. The plant should be removed from the room.
What are the management strategies for an area with an Annual Parasitic Index (API) less than a certain threshold?
- Regular insecticidal spray
- Passive surveillance
- Detected cases get radical treatment
- Collection of follow-up blood smears
Explanation: Answer reason: For low-API areas, vector control through scheduled residual insecticidal spraying is a key public health strategy to prevent transmission; the other options reflect surveillance and case management activities rather than the primary prevention measure.
Which solution is effective for disinfecting instruments to make them free of the HIV virus when kept for 24 hours?
- Spirit for 24 hours
- 2% glutaraldehyde solution
- Solution (1:100 strength)
- Hydrogen Peroxide
Explanation: Answer reason: 2% glutaraldehyde (Cidex) is a high-level disinfectant that is virucidal, including against HIV, and is used for cold disinfection of instruments; the other options are not reliable for instrument high-level disinfection.
Which education points should the nurse prioritize for a patient with keratitis secondary to contact lens wear?
- Rinse lenses in tap water before use
- Replace lenses as prescribed
- Avoid sleeping in contact lenses
- Apply makeup after removing lenses
Explanation: Answer reason: Adhering to the recommended replacement schedule reduces biofilm and microbial buildup on lenses, lowering keratitis risk. Tap water is unsafe for lenses; sleeping in lenses increases risk but only one priority is asked; the makeup statement is incorrect.
What is an appropriate nursing intervention for a newborn's myelomeningocele prior to surgery?
- Leaving the sac open to air
- Applying petrolatum to cover the sac
- Applying moist saline dressings
- Applying dry dressings
Explanation: Answer reason: For myelomeningocele, the sac must be kept sterile and moist to prevent drying and infection before surgery. Use sterile normal saline–moistened dressings. Leaving it open, using petrolatum, or dry dressings increases risk of rupture and infection.
What should the infection control nurse recommend during a norovirus outbreak in the facility?
- Staff wears a surgical mask when providing client care.
- Disposable utensils and dishware are used for meals.
- Dietary staff wears a face shield when preparing client meals.
- Commonly touched surfaces be disinfected with a bleach solution.
Explanation: Answer reason: Norovirus is highly contagious and environmentally hardy; effective control requires bleach-based disinfection of high-touch surfaces. Routine masking or face shields for meal prep and using disposable dishware are not standard control measures.
What type of disinfection is performed after the discharge of material from the body of an infected person?
- Terminal disinfection
- Concurrent disinfection
- Primary disinfection
Explanation: Answer reason: Concurrent disinfection is applied immediately after infectious material is discharged from the patient; terminal disinfection is done after the patient leaves or recovers.
Which of the following is an important nursing intervention for a patient with Cushing syndrome?
- Assess left middle cerebral artery
- Observe for hypotension
- Protect from infection
- Restrict carbohydrate intake
Explanation: Answer reason: Cushing syndrome causes immunosuppression from excess cortisol, increasing infection risk; protecting the patient from infection is a key nursing intervention. Hypotension is unlikely (hypertension is common), assessing the left MCA is unrelated, and carbohydrate restriction is less critical than infection prevention.
What is the term for infections acquired by patients within a clinical facility?
- Community acquired infection
- Society acquired infection
- Family acquired infection
- Hospital-acquired infection
Explanation: Answer reason: Infections that develop during a stay in a healthcare facility are termed hospital-acquired (nosocomial) infections.
A baby born 2 hours ago by Cesarean section has a myelomeningocele with an intact sac and has been placed in an incubator; what potential complication should the nurse focus on when planning care?
- Disuse syndrome
- Infection
- Fluid volume deficit
- Decreased cardiac output
Explanation: Answer reason: Newborns with myelomeningocele are at high risk for meningitis and wound contamination, even with an intact sac. Preventing infection is the priority complication to focus on in early care.
What term describes the restriction of activities of healthy persons or animals who have been exposed to a communicable disease?
- Isolation
- Quarantine
- Contamination
- Carriers
Explanation: Answer reason: Quarantine is the restriction of movement/activities of persons exposed but not yet ill to prevent disease spread. Isolation is for those already infected; contamination and carriers do not describe the control measure.
Which of the following is an early sign of infection in a postoperative wound?
- Fever
- Purulent drainage
- Redness and warmth at the incision site
- Increased white blood cell count
Explanation: Answer reason: Local signs such as erythema and warmth at the incision occur early in wound infection; fever, purulent drainage, and leukocytosis are later systemic findings.
What position helps reduce the risk of ventilator-associated pneumonia (VAP) in a patient on mechanical ventilation?
- Supine
- High Fowler’s
- Head of bed 30-45°
- Right lateral
Explanation: Answer reason: Elevating the head of the bed 30–45° reduces aspiration of secretions and gastric contents, a key VAP prevention measure. Supine increases risk; High Fowler’s (60–90°) is not the guideline for ventilated patients.
Which of the following is NOT an important principle of bag technique?
- Should save time and effort
- Should minimise prevent spread of infection
- Should overshadow concern of patient and his family
- May be done in variety of ways depending on home situation
Explanation: Answer reason: Bag technique principles aim to save time, prevent infection, and adapt to the home setting. They should not compromise or overshadow patient and family concerns, making option C the incorrect principle.
While providing wound care, how should the nurse clean the wound?
- From center to periphery
- From periphery to center
- By considering wound into left and right halves
- By considering wound into upper and lower halves
Explanation: Answer reason: The wound should be cleaned from the least contaminated area (center) to the most contaminated area (periphery) to prevent the spread of microorganisms into the wound. Each stroke uses a new sterile swab to reduce infection risk.
A client who is receiving chemotherapy through a central line is admitted to the hospital with a diagnosis of sepsis. Which of the following nursing interventions should receive PRIORITY?
- Inspect all sites that may serve as entry ports for bacteria
- Place the client in reverse isolation
- Change the dressing over the site of the central line
- Restrict contact with persons having known or recent infections
Explanation: Answer reason: In a septic patient, the priority is rapid assessment to identify the source of infection so treatment can be initiated. Inspecting potential entry sites (e.g., central line, wounds) addresses this first. Reverse isolation and contact restriction are preventive, and changing the dressing is not the initial priority in active sepsis.
A surgical client develops a wound infection during hospitalization. How is this type of infection classified?
- Primary
- Secondary
- Superimposed
- Nosocomial
Explanation: Answer reason: An infection acquired in the hospital setting is classified as a nosocomial (hospital-acquired) infection.
A client is being admitted to a medical unit with a diagnosis of tuberculosis. Which type of room should this client be assigned by the nurse?
- Private room
- Semiprivate room
- Room with windows that can be opened
- Negative airflow room.
Explanation: Answer reason: Tuberculosis is an airborne disease; clients must be placed in an airborne infection isolation room (AIIR), also called a negative-airflow or negative-pressure room. These rooms prevent contaminated air from flowing into hallways by maintaining lower pressure inside the room and filtering exhaust air. This is the highest-level isolation required for TB.
Which physical assessment finding is most indicative of a systemic infection?
- Nasal drainage
- Bilateral 3+ pitting pedal edema
- Oral temperature of 101.1°F
- Pale skin and nail bed color
Explanation: Answer reason: Fever (101.1°F) indicates a systemic inflammatory response consistent with systemic infection; the other findings suggest local symptoms or noninfectious conditions.
What action by the nurse is most important when performing a dressing change using surgical aseptic technique?
- Comforting the client
- Maintaining sterility
- Obtaining extra gloves
- Organizing supplies.
Explanation: Answer reason: In a sterile dressing change, the critical priority is maintaining sterility to prevent infection; the other actions are secondary.
Which family member exposed to TB is at highest risk for contracting the disease?
- 45 year old mother
- 17 year old daughter
- 8 year old son
- 76 year old grandmother
Explanation: Answer reason: Elderly individuals have decreased immune function, placing them at higher risk of contracting and progressing to active tuberculosis compared with healthy adults and adolescents.
A client with frequent urinary tract infections asks the nurse how she can prevent the reoccurrence. The nurse should teach the client to?
- Douche after intercourse
- Void every 3 hours
- Obtain a urinalysis monthly
- Wipe from back to front after voiding
Explanation: Answer reason: Frequent voiding reduces urinary stasis and bacterial growth, helping prevent recurrent UTIs. Douching can increase risk, routine monthly urinalysis does not prevent infection, and wiping back to front promotes contamination.
The physician has ordered a histoplasmosis test for the elderly client. The nurse is aware that histoplasmosis is transmitted to humans by?
- Cats
- Dogs
- Turtles
- Birds
Explanation: Answer reason: Histoplasmosis (Histoplasma capsulatum) is acquired by inhaling fungal spores from soil contaminated with bird or bat droppings; among the options, birds best represent the source.
The nurse is teaching the client with AIDS regarding needed changes in food preparation. Which statement indicates that the client understands the nurse's teaching?
- Adding fresh ground pepper to my food will improve the flavor.
- Meat should be thoroughly cooked to the proper temperature.
- Eating cheese and yogurt will prevent AIDS-related diarrhea.
- It is important to eat four to five servings of fresh fruits and vegetables a day.
Explanation: Answer reason: Immunocompromised clients should avoid foodborne pathogens by cooking meats thoroughly. Fresh ground pepper and raw produce can harbor microbes, and dairy products do not prevent AIDS-related diarrhea.
The chart of a client hospitalized for a total hip repair reveals that the client is colonized with MRSA. The nurse understands that the client?
- Will not display symptoms of infection
- Is less likely to have an infection
- Can be placed in the room with others
- Cannot colonize others with MRSA
Explanation: Answer reason: Colonization indicates MRSA is present without causing active disease, so the client has no signs or symptoms. They remain at risk for transmission and should not be roomed with non-colonized clients.
After attending a company picnic, several clients are admitted to the emergency room with E. coli food poisoning. The most likely source of infection is?
- Hamburger
- Hot dog
- Potato salad
- Baked beans
Explanation: Answer reason: Coli O157:H7 is most commonly linked to undercooked ground beef; hamburgers at picnics are a typical source. Hot dogs are cooked/processed, potato salad is more associated with Staphylococcus aureus, and baked beans are less likely.
A pediatric client is admitted to the hospital for treatment of diarrhea caused by an infection with salmonella. Which of the following most likely contributed to the child's illness?
- Brushing the family dog
- Playing with a turtle
- Taking a pony ride
- Feeding the family cat
Explanation: Answer reason: Reptiles, especially turtles, commonly carry Salmonella and can transmit it to children through handling or contact. Dogs, cats, and pony rides are less typical sources.
A client is admitted with disseminated herpes zoster. According to the Centers for Disease Control Guidelines for Infection Control?
- Airborne precautions will be needed.
- No special precautions will be needed.
- Contact precautions will be needed.
- Droplet precautions will be needed.
Explanation: Answer reason: Disseminated herpes zoster (varicella-zoster virus) is spread by both airborne and contact routes. Immunocompromised clients or those with widespread lesions require full airborne isolation plus contact precautions to prevent transmission of aerosolized viral particles.
The nurse is aware that the best way to prevent post-operative wound infection in the surgical client is to?
- Administer a prescribed antibiotic
- Wash her hands for 2 minutes before care
- Wear a mask when providing care
- Ask the client to cover her mouth when she coughs
Explanation: Answer reason: Hand hygiene is the single most effective measure to prevent surgical site and wound infections; antibiotics or masks are adjuncts and not as universally effective.
The nurse is preparing to suction the client with a tracheotomy. The nurse notes a previously used bottle of normal saline on the client's bedside table. There is no label to indicate the date or time of initial use. The nurse should?
- Lip the bottle and use a pack of sterile 4x4 for the dressing
- Obtain a new bottle and label it with the date and time of first use
- Ask the ward secretary when the solution was requested
- Label the existing bottle with the current date and time
Explanation: Answer reason: An opened solution without a date/time is considered potentially contaminated. For tracheostomy suctioning sterile technique is required; discard the questionable bottle, obtain a new one, and label it at first use.
During a home visit, a client with AIDS tells the nurse that he has been exposed to measles. Which action by the nurse is most appropriate?
- Administer an antibiotic
- Contact the physician for an order for immune globulin
- Administer an antiviral
- Tell the client that he should remain in isolation for 2 weeks
Explanation: Answer reason: Immunocompromised clients exposed to measles should receive immune globulin within 6 days to prevent or modify disease. Antibiotics do not treat measles, there is no specific antiviral therapy, and isolation alone is not the priority intervention.
Teaching the mother about treatment for pediculosis capitis. Which instruction is correct?
- Treatment is not recommended for children less than 10 years of age.
- Bed linens should be washed in hot water.
- Medication therapy will continue for 1 year.
- Intravenous antibiotic therapy will be ordered.
Explanation: Answer reason: Pediculosis capitis is treated with topical pediculicide; linens and clothing must be laundered in hot water to kill lice and nits. Therapy is not IV, does not last a year, and is safe in young children.
What is the recommended period of isolation for a child with mumps?
- 21 days
- 7 days
- 14 days
- 10 days
Explanation: Answer reason: Mumps is spread by respiratory droplets; standard teaching recommends isolating affected children for about two weeks to limit transmission. Thus, 14 days is the best choice among the options.
The nurse is caring for a client hospitalized with nephotic syndrome. Based on the client's treatment, the nurse should?
- Limit the number of visitors
- Provide a low-protein diet
- Discuss the possibility of dialysis
- Offer the client additional fluids
Explanation: Answer reason: Clients with nephrotic syndrome are commonly treated with corticosteroids, which increase infection risk; limiting visitors helps reduce exposure. A low-protein diet is not indicated (protein losses require adequate intake), dialysis is not typical, and fluids are usually restricted due to edema.
Which statement describes the contagious stage of varicella?
- The contagious stage is 1 day before the onset of the rash until the appearance of vesicles.
- The contagious stage lasts during the vesicular and crusting stages of the lesions.
- The contagious stage is from the onset of the rash until the rash disappears.
- The contagious stage is 1 day before the onset of the rash until all the lesions are crusted.
Explanation: Answer reason: Varicella is communicable from about 1 day before rash onset until all lesions have crusted; once crusted, transmission risk is minimal.
A client with a C4 spinal cord injury has been placed in traction with cervical tongs. Nursing care should include?
- Releasing the traction for 5 minutes each shift
- Loosening the pins if the client complains of headache
- Elevating the head of the bed 90°
- Performing sterile pin care as ordered
Explanation: Answer reason: Cervical tongs traction must remain continuous and pins are never loosened; HOB is not raised to 90°. Sterile pin-site care is required to prevent infection.
A 5-month-old is diagnosed with atopic dermatitis. Nursing interventions will focus on?
- Preventing infection
- Administering antipyretics
- Keeping the skin free of moisture
- Limiting oral fluid intake
Explanation: Answer reason: Atopic dermatitis disrupts the skin barrier and itching leads to excoriations, making secondary infection a priority risk. Antipyretics are not indicated, skin should be moisturized rather than kept dry, and fluid restriction is unnecessary.
Which of the following is used for sterilization of cystoscopes, endoscopes, and bronchoscopes?
- Glutaraldehyde
- Ethanol
- Methanol
- Ethylene oxide
Explanation: Answer reason: Glutaraldehyde is a high-level disinfectant used for cold sterilization of heat-sensitive instruments like flexible endoscopes, cystoscopes, and bronchoscopes; alcohols are low-level disinfectants and ethylene oxide is not typically used for these scopes.
What is a person called who carries a disease-producing organism without showing any symptoms?
- Host
- Carrier
- Agent
Explanation: Answer reason: An asymptomatic individual who harbors and can transmit a pathogen is a carrier; a host is any organism that harbors the pathogen, and the agent is the pathogen itself.
What is the oldest communicable disease control measure?
- Quarantine
- Isolation
- Health education
Explanation: Answer reason: Isolation of the sick (e.g., lepers) has been practiced since ancient times, predating the later concept of quarantine from the 14th century.
What is the final step in the purification of water?
- Filtration
- Addition of lime
- Chlorination
Explanation: Answer reason: The final stage in water treatment is disinfection; chlorination kills remaining microorganisms after earlier steps like coagulation/filtration.
The client with AIDS tells the nurse that he has been using acupuncture to help with his pain. The nurse should question the client regarding this treatment because acupuncture uses?
- Pressure from the fingers and hands to stimulate the energy points in the body
- Oils extracted from plants and herbs
- Needles to stimulate certain points on the body to treat pain
- Manipulation of the skeletal muscles to relieve stress and pain
Explanation: Answer reason: Acupuncture involves inserting needles at specific points. In an immunocompromised client with AIDS, needle use poses infection risk, so the nurse should question this therapy.
The charge nurse is making assignments for the day. After accepting the assignment to a client with leukemia, the nurse tells the charge nurse that her child has chickenpox. Which initial action should the charge nurse take?
- Change the nurse’s assignment to another client
- Explain to the nurse that there is no risk to the client
- Ask the nurse if the chickenpox have scabbed
- Ask the nurse if she has ever had the chickenpox
Explanation: Answer reason: First assess the nurse’s immunity to varicella. If she has had chickenpox (or is immune), risk to an immunocompromised leukemia client is minimal; if not, reassignment is needed. Assessment precedes intervention.
The nurse caring for the child with a large meningomyelocele is aware that the priority care for this client is to?
- Cover the defect with a moist, sterile saline gauze
- Place the infant in a supine position
- Feed the infant slowly
- Measure the intake and output
Explanation: Answer reason: An open meningomyelocele sac is highly susceptible to drying and infection. The priority is to protect the sac with a moist, sterile saline dressing. Supine positioning risks pressure/rupture, and feeding or I&O are not the immediate priority.
The nurse is aware that a common mode of transmission of clostridium difficile is?
- Use of unsterile surgical equipment
- Contamination with sputum
- Through the urinary catheter
- Contamination with stool
Explanation: Answer reason: Difficile spreads via the fecal–oral route; spores are shed in stool and contaminate hands and surfaces. Sputum, urinary catheters, or unsterile surgical equipment are not common transmission routes.
Which of the following roommates would be best for the client newly admitted with gastric resection?
- A client with Crohn’s disease
- A client with pneumonia
- A client with gastritis
- A client with phlebitis
Explanation: Answer reason: Postoperative gastric resection patients should avoid exposure to infectious roommates. Phlebitis is a localized, non-infectious condition, whereas pneumonia poses respiratory infection risk and GI conditions may involve higher contamination risk. Thus the safest roommate is the client with phlebitis.
To assist with the prevention of urinary tract infections, the teenage girl should be taught to?
- Drink citrus fruit juices
- Avoid using tampons
- Take showers instead of tub baths
- Clean the perineum from front to back
Explanation: Answer reason: Front-to-back perineal cleansing prevents transfer of fecal bacteria (e.g., E. coli) to the urethra, reducing UTI risk. Tampons are not a UTI risk, citrus juices are not evidence-based for prevention, and showers over baths are less critical than proper wiping technique.
Which of the following roommates would be most suitable for the client with myasthenia gravis?
- A client with hypothyroidism
- A client with Crohn’s disease
- A client with pyelonephritis
- A client with bronchitis
Explanation: Answer reason: Myasthenia gravis clients must avoid infection risk due to respiratory weakness. Hypothyroidism is non-infectious, while the others pose infection risk.
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