Embryology Practice Test 1
Embryology NCLEX Practice Test
Embryology, within the NCLEX test plan under Nursing Science → Clinical Foundations, reflects the core knowledge domains and conceptual competencies directly related to what the exam evaluates. The targeted number of questions is 50; designed with realistic clinical scenarios and conceptual variety to help you identify both your strengths and improvement areas.
This test is the 1st part of the Embryology section. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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In the Embryology Study Cards section, shared by real NCLEX candidates, you’ll find concise summaries and high-yield insights related to the most tested concepts. It’s a perfect space to reinforce challenging topics and sharpen your recall through quick, focused repetitions. Short, powerful, and repeatable!
Embryology Practice Test 1
Incomplete fusion of two medial nasal swelling results in the production of?
- Lateral cleft of upper lip
- Medial cleft of upper lip
- Macrostomia
- Microstomia
Explanation: Answer reason: The upper lip forms through fusion of the two medial nasal swellings with the maxillary prominences. Failure of the two medial nasal swellings to fuse results specifically in a median (medial) cleft lip, a rare midline facial defect. Lateral clefts involve maxillary–medial nasal fusion failure, not medial–medial fusion.
Failure of the foramen ovale to close will lead to?
- Patent ductus arteriosus
- Transposition of the great arteries
- Atrial septal defect
- Ventricular septal defect
Explanation: Answer reason: The foramen ovale is a fetal interatrial opening that normally closes after birth. Failure to close results in a patent foramen ovale, which is an atrial septal defect.
What is the first organ to develop in the fetus?
- Liver
- Brain
- Heart
- Kidney
Explanation: Answer reason: The heart is the first functional organ to form in the embryo, beginning to beat and circulate blood by about week 3.
What is the first organ that develops in the fetus?
- Brain
- Liver
- Kidney
- Lung
- Heart
Explanation: Answer reason: The embryonic heart is the first functional organ to form and begins beating around week 3 of gestation, earlier than the brain, liver, kidneys, and lungs.
Which organ develops first in the fetus?
- Heart
- Kidney
- Liver
- Stomach
Explanation: Answer reason: The heart is the first functional organ to form; cardiogenesis begins in week 3, and it starts beating early in embryonic development.
What is the most common type of twin pregnancy?
- Monozygotic twins
- Dizygotic twins
- Conjoined twins
- Monoamniotic twins
Explanation: Answer reason: Dizygotic (fraternal) twins result from the fertilization of two separate ova and are far more common than monozygotic, conjoined, or monoamniotic twins.
What is the most common type of tracheoesophageal fistula?
- Esophageal atresia without tracheoesophageal fistula
- Esophageal atresia with tracheoesophageal fistula
- Esophageal atresia with distal tracheoesophageal fistula
- Esophageal atresia with proximal and distal fistulas
Explanation: Answer reason: Type C (esophageal atresia with a distal tracheoesophageal fistula) accounts for the vast majority of TEF cases, approximately 85%.
Incomplete fusion of the two medial nasal swellings results in the production of?
- Lateral cleft of the upper lip
- Medial cleft of the upper lip
- Macrostomia
- Microstomia
- Oblique facial cleft
Explanation: Answer reason: The two medial nasal prominences normally fuse to form the intermaxillary segment and the philtrum of the upper lip. Failure of their fusion results in a median (medial) cleft of the upper lip. A lateral cleft involves failure of fusion between the maxillary and medial nasal prominences; macro- and microstomia involve maxillary–mandibular fusion defects; an oblique facial cleft involves maxillary–lateral nasal failure.
At what week do the fetal kidneys start secreting urine?
- 10th week
- 12th week
- 16th week
- 20th week
Explanation: Answer reason: The metanephric kidneys begin producing urine around the 10th week of gestation; fetal urine subsequently contributes to amniotic fluid volume.
How many arteries and veins does the umbilical cord consist of?
- Two arteries and one vein.
- 1 artery and 1 vein
- One artery and two veins
- Two arteries and two veins
Explanation: Answer reason: The typical umbilical cord contains two umbilical arteries carrying deoxygenated blood from the fetus and one umbilical vein carrying oxygenated blood to the fetus.
Which of the following brainstem nuclei is not derived from the alar plate?
- Hypoglossal nuclei
- Inferior olivary nucleus
- Dentate nucleus
- Substantia nigra
Explanation: Answer reason: Alar plate derivatives are primarily sensory (e.g., the inferior olivary nuclei and cerebellar nuclei, like the dentate). The hypoglossal nucleus is a somatic motor cranial nerve nucleus derived from the basal plate, not the alar plate.
The umbilical cord is also known as?
- Belt string
- Navel string
- Bag string
- Theory string
Explanation: Answer reason: The umbilical cord has historically been referred to as the navel string, connecting the fetus at the umbilicus to the placenta.
The first bone to begin ossification is?
- Astragalus
- Clavicle
- Radius
- Scapula
- Scaphoid
Explanation: Answer reason: The clavicle is the first bone to ossify in the embryo, beginning intramembranous ossification around the 5th–6th week of gestation. Others, like the scaphoid, ossify much later.
Which organ develops first in the embryo?
- Heart
- Lungs
- Liver
- Kidney
- None
Explanation: Answer reason: The heart is the first functional organ to form in the embryo, beginning to beat and circulate blood by about the third or fourth week of gestation.
From which structure is the fetus formed?
- Morula
- Blastocyst
- Inner cell mass
- Syncytiotrophoblast
Explanation: Answer reason: The embryo (and thus the fetus) develops from the embryoblast, also called the inner cell mass, of the blastocyst. The trophoblast forms placenta-related tissues; morula and blastocyst are earlier stages, not the specific cell population forming the fetus.
Through what does the blood from the pregnant mother reach the fetus?
- Umbilical cord
- Umbilical atrium
- Umbilical veins
- None of the above
Explanation: Answer reason: Oxygenated maternal blood reaches the fetus via the placenta and then is carried to the fetus through the umbilical vein (within the cord).
Prenatal in ovum period, how many days?
- 45 days
- 13 days
- 28 days
- 14 days
Explanation: Answer reason: Prenatal development is divided into the ovum (germinal) period lasting about the first 14 days after fertilization, followed by the embryonic and fetal periods.
The blood from the pregnant mother reaches the fetus through what?
- Umbilical cord
- Umbilical atrium
- Umbilical veins
- None of the above
Explanation: Answer reason: Oxygenated maternal blood from the placenta reaches the fetus through the umbilical vein in the umbilical cord; the other options are incorrect or nonspecific.
After birth, in a normal neonate, the ductus arteriosus becomes?
- Venous ligament
- Ligamentum venosum
- Ligamentum teres
- Ligamentum arteriosum
Explanation: Answer reason: After birth the fetal ductus arteriosus closes and fibroses to form the ligamentum arteriosum; ductus venosus becomes ligamentum venosum and the umbilical vein becomes ligamentum teres.
The fetus connects to the placenta by the umbilical cord; a normal umbilical cord contains...?
- One vein and two arteries.
- One artery and two veins.
- One vein and one artery
- Two arteries and two veins
Explanation: Answer reason: A normal umbilical cord contains two umbilical arteries and one umbilical vein; thus, one vein and two arteries.
After birth, the umbilical artery collapses and forms?
- Ligamentum arteriosum
- Ligamentum venosum
- Medial umbilical ligament
- Lateral umbilical ligament
Explanation: Answer reason: Postnatally, the distal portions of the umbilical arteries obliterate and form the paired medial umbilical ligaments; the proximal parts persist as superior vesical arteries. Ligamentum arteriosum derives from the ductus arteriosus, and ligamentum venosum from the ductus venosus; the lateral umbilical fold contains the inferior epigastric vessels.
After the birth of the baby, the foramen ovale closes and it becomes...?
- Ligamentum venosum
- Ductus arteriosus
- Ductus venosus
- Fossa ovalis
Explanation: Answer reason: After birth, increased left atrial pressure functionally closes the foramen ovale, which becomes the fossa ovalis. Ductus arteriosus becomes ligamentum arteriosum and ductus venosus becomes ligamentum venosum.
At which week are fetal circulation functions well developed?
- 8th week
- 6th week
- 12th week
- 28th week
Explanation: Answer reason: Fetoplacental circulation becomes well established by the end of the first trimester, around the 12th week.
After birth, the umbilical vein collapses and forms?
- Ligamentum arteriosum
- Ligamentum venosum
- Umbilical ligament
- Ligamentum teres
Explanation: Answer reason: Postnatally, the umbilical vein becomes the ligamentum teres hepatis (round ligament of the liver). Ductus venosus becomes ligamentum venosum, and ductus arteriosus becomes ligamentum arteriosum.
A fertilized ovum is implanted in the uterus after?
- 7 days
- 1 day
- 8 days
- 10 days
Explanation: Answer reason: Implantation (nidation) of the blastocyst typically begins about 6–7 days after fertilization; thus 7 days is the best option.
The umbilical vein, carrying blood from the placenta, enters the foetus with?
- Oxygenated blood at 80% saturation
- Oxygenated blood at 25% saturation
- Oxygenated blood at 35% saturation
- Oxygenated blood at 60% saturation
Explanation: Answer reason: In fetal circulation, the umbilical vein carries the most oxygenated blood from the placenta to the fetus with about 80% oxygen saturation.
Oxygenated blood enters the fetal circulation from the umbilical vein via?
- Ductus arteriosus
- Ductus venosus
- Foramen ovale
- Umbilical artery
Explanation: Answer reason: Oxygenated blood from the placenta travels through the umbilical vein and bypasses the liver via the ductus venosus to the inferior vena cava. The ductus arteriosus connects pulmonary artery to aorta, the foramen ovale shunts RA to LA, and the umbilical arteries carry deoxygenated blood to the placenta.
Esophageal atresia may occur as a part of VATER group of anomalies. What does 'TE' stand for?
- Tetralogy of fallot
- Thoracic empyema
- Tracheo- esophageal fistula
- Talipes equinovarus
Explanation: Answer reason: In the VATER/VACTERL association, TE refers to tracheoesophageal fistula (often with esophageal atresia).
Communication between aorta and pulmonary artery in fetal circulation is known as........?
- Foramen ovale
- Ductus arteriosus
- Ductus venosus
- Fossa ovalis
Explanation: Answer reason: In fetal circulation, the ductus arteriosus connects the pulmonary artery to the aorta, bypassing the nonfunctioning lungs. Foramen ovale is an atrial shunt; ductus venosus connects the umbilical vein to the IVC; fossa ovalis is the postnatal remnant of the foramen ovale.
The earliest organ to form and began function within the developing human is the?
- Stomach
- Lungs
- Brain
- Heart
Explanation: Answer reason: The heart is the first functional organ in the embryo, beginning to beat and circulate blood around week 3–4 of development.
Which information about developmental stages and milestones in a normally developing fetus should a nurse include?
- The testes at the inguinal ring descend to scrotum at 12 weeks.
- The bladder and urethra separate from the rectum at 4-7 weeks.
- The kidneys are in position at 16 weeks with typical shape and plan.
Explanation: Answer reason: Division of the embryonic cloaca into the urogenital tract and anorectal canal occurs during the first trimester; many references place this separation by about 12 weeks. Testicular descent to the scrotum occurs much later (third trimester), and the kidneys reach their final position by around 9 weeks, not 16.
Which of the following changes does NOT occur to the fetal circulation within minutes of birth?
- Constriction of the umbilical vessels
- Constriction of the ductus venosus
- Constriction of the ductus arteriosus
- Constriction of the hepatic portal sinus
- Closure of the foramen ovale
Explanation: Answer reason: Immediately after birth, umbilical vessels constrict, the ductus venosus and ductus arteriosus begin functional closure, and the foramen ovale closes due to pressure changes. There is no physiologic constriction of a 'hepatic portal sinus' as an immediate postnatal change.
What is the function of the foramen ovale in fetal circulation?
- Allow oxygenated blood to flow from the right to the left atrium
- Shunt blood from the pulmonary artery to the aorta
- Allow blood into the pulmonary veins
- Allow nutrient exchange between mother and fetus
Explanation: Answer reason: The foramen ovale connects the right and left atria in the fetus, allowing oxygenated blood from the IVC to bypass the nonfunctional lungs by flowing directly from the right atrium to the left atrium.
What is the correct definition of the term fetus?
- The baby, it is mature enough to survive once outside the womb.
- The maternal tissue, plus the umbilicus and placenta.
- The unborn offspring, from the end of the 8th week of conception until birth.
- The unborn child, as soon as conception occurs.
Explanation: Answer reason: The fetal period begins at the end of the 8th week after conception (9th gestational week) and lasts until birth; earlier is the embryonic stage.
What is phocomelia?
- Absence of long bones
- Absence of brain
- Reduplication of bones
Explanation: Answer reason: Phocomelia is a congenital limb defect characterized by absence or severe hypoplasia of the long bones, producing flipper-like limbs. B describes anencephaly; C refers to duplication anomalies.
At which age does the human fetus start to secrete the hormone thyroxin?
- 12th week of gestation
- 24th week of gestation
- 6th week of gestation
- 32nd week of gestation
Explanation: Answer reason: The fetal thyroid begins iodine trapping and hormone synthesis around 10–12 weeks of gestation, so thyroxine secretion starts near the 12th week.
How many vessels are normally present in the umbilical cord after delivery?
- One artery and one vein
- One artery and two veins
- Two arteries and two veins
- Two arteries and one vein
Explanation: Answer reason: A normal umbilical cord contains three vessels: two arteries and one vein.
Failure of the foramen ovale to close causes what congenital heart disease?
- Atrial septal defect
- Pulmonary stenosis
- Transposition of great arteries
- Total anomalous pulmonary artery
Explanation: Answer reason: Persistence of the foramen ovale results in a patent foramen ovale, a type of atrial septal defect. The other options involve different congenital cardiac abnormalities.
Which of the following structures is NOT necessary for blastocyst implantation?
- Endometrium in progestational phase
- Zona pellucida
- Syncytiotrophoblast
- Cytotrophoblast
- Functional layer of endometrium
Explanation: Answer reason: Successful implantation requires the blastocyst to hatch from and shed the zona pellucida so trophoblast (syncytiotrophoblast and cytotrophoblast) can invade the receptive, progesterone-primed functional endometrium. Therefore the zona pellucida is not necessary and must be absent.
How many arteries and veins are present in the umbilical cord?
- Two arteries and two veins
- Two veins and one artery
- Two arteries and one vein
- One artery and one vein
Explanation: Answer reason: The normal umbilical cord contains two umbilical arteries and one umbilical vein.
At what week can fetal gender be determined?
- 5 weeks
- 7 weeks
- 8 weeks
- 12 weeks
Explanation: Answer reason: External genitalia are sufficiently differentiated to identify fetal sex by ultrasound around 12 weeks of gestation.
At what time does ossification start in the fetus?
- 3 month
- 5 month
- 3 weeks
- 5 weeks
Explanation: Answer reason: The first fetal bone to ossify (clavicle) begins intramembranous ossification around the 5th week of gestation.
What is the first organ that develops in the fetus?
- Brain
- Liver
- Kidney
- Lung
- Heart
Explanation: Answer reason: The heart is the first functional organ to form in the embryo, beginning to beat around week 3–4 of gestation.
Incomplete fusion of two medial nasal swelling results in the production of?
- Lateral cleft of upper lip
- Medial cleft of upper lip
- Macrostomia
- Microstomia
- Oblique facial cleft
Explanation: Answer reason: The medial nasal swellings fuse to form the intermaxillary segment (philtrum). Failure of fusion between the two medial nasal swellings leads to a median cleft of the upper lip.
Failure of foramen ovale to close causes which congenital heart disease?
- Total anomalous pulmonary artery
- Atrial septal defect
- Transposition of great arteries
- Pulmonary stenosis
Explanation: Answer reason: The foramen ovale normally closes after birth as left atrial pressure rises. Failure of closure results in a patent foramen ovale, a form of atrial septal defect.
During feto-placental circulation, the shunt between atria is called?
- Ductus venosus
- Foramen magnum
- Ductus arteriosus
- Foramen ovale
Explanation: Answer reason: The foramen ovale is the fetal interatrial shunt allowing blood to flow from the right atrium to the left atrium. Ductus venosus bypasses the liver, ductus arteriosus connects pulmonary artery to aorta, and foramen magnum is a skull opening.
What is the average length of the umbilical cord in centimeters?
- 40 cm
- 60 cm
- 70 cm
- 80 cm
Explanation: Answer reason: The umbilical cord typically measures about 50–60 cm at term; 60 cm is the standard average among the choices.
Which of the following drugs is a known fetal teratogen?
- Marijuana
- Alcohol
- Heroin
- Caffeine
- Nicotine
Explanation: Answer reason: Alcohol is a well-established teratogen that causes fetal alcohol spectrum disorders with craniofacial, growth, and neurodevelopmental defects. The others are harmful but not classic teratogens.
The cell from which the human body develops is known as?
- Overy
- Ovum
- Zygote
- Sperm
Explanation: Answer reason: A zygote is the fertilized egg cell formed by fusion of ovum and sperm and is the single cell from which the entire human body develops. Ovum and sperm are gametes, and 'overy' is an organ, not a cell.
Which of the following medications is NOT associated with central nervous system abnormalities?
- Valproic acid
- Methotrexate
- Tegretol
- Vitamin A
- Thalidomide
Explanation: Answer reason: Valproic acid, methotrexate, and carbamazepine (Tegretol) are linked to neural tube/CNS defects; excess vitamin A derivatives (retinoids such as isotretinoin) causes CNS and craniofacial anomalies. Thalidomide classically causes limb reduction defects, not CNS abnormalities.
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