Pathophysiology Practice Test 5
Pathophysiology NCLEX Practice Test
Pathophysiology is a key topic within the NCLEX test plan, located under Physiological Integrity → Physiological Adaptation → Pathophysiology. This section integrates disease mechanisms with nursing assessments and prioritized interventions. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 5th part of the Pathophysiology series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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Pathophysiology Practice Test 5
During the assessment of a child with pulmonic stenosis, the nurse would anticipate observing which of the following?
- Hyperactivity
- Normal respiratory rate
- Systolic ejection murmur
- Capillary refill more than 2 seconds
Explanation: Answer reason: This classically results in a crescendo-decrescendo systolic ejection murmur, often best heard at the left upper sternal border and may be associated with an ejection click. A normal respiratory rate is not a defining expected finding in a hemodynamically significant outflow obstruction, and respiratory symptoms can occur with more severe disease. Delayed capillary refill suggests systemic hypoperfusion/shock, which is not the typical primary presentation of isolated pulmonic stenosis, and hyperactivity is nonspecific.
A nurse is assessing a toddler with hypothyroidism. During the assessment, the nurse is most concerned when the toddler presents with which finding?
- Low hemoglobin and hematocrit
- Cyanosis
- Bone and muscle dystrophy
- Mental retardation
Explanation: Answer reason: In a toddler, signs suggesting significant developmental impact indicate the highest-stakes complication because it reflects prolonged, clinically consequential hormone deficiency. Other findings like anemia or musculoskeletal changes can occur with hypothyroidism but are generally less urgent and more reversible with treatment. Cyanosis is not a typical hypothyroidism manifestation and suggests an alternate acute cardiopulmonary issue rather than the expected endocrine complication profile.
The nurse has just admitted a client with sickle cell crisis. What is the priority intervention by the nurse?
- Giving blood transfusions
- Giving antibiotics
- Increasing fluid intake and giving analgesics
- Preparing the client for a splenectomy
Explanation: Answer reason: Immediate priority nursing care is to improve perfusion by aggressive hydration (often IV) and to treat pain promptly with appropriate analgesia, helping reduce further sickling and stress-related oxygen demand. Blood transfusion is reserved for specific severe complications (e.g., acute chest syndrome, stroke, severe anemia) rather than being the universal first step on admission. Antibiotics are indicated only when infection is suspected/confirmed, and splenectomy is not an acute priority intervention for a pain crisis.
The client is diagnosed with pericarditis. Which signs/symptoms should the nurse expect in this client?
- The client has pulsus paradoxus and night sweats.
- Complaints of fatigue and arthralgias.
- Constant chest pain and friction rub.
- Increased chest pain when ambulating but not at rest.
Explanation: Answer reason: Pericarditis is inflammation of the pericardial layers, producing sharp, persistent pleuritic chest pain and a characteristic pericardial friction rub from the inflamed surfaces rubbing together. The pain classically worsens with inspiration and when lying flat and improves when sitting up/leaning forward, making it more continuous than exertional ischemic pain. Pulsus paradoxus is more suggestive of significant pericardial effusion/tamponade (a complication), not an expected routine presentation. Fatigue and arthralgias can occur with systemic inflammatory illnesses but are nonspecific and do not best represent the hallmark findings of acute pericarditis.
The nurse is admitting a client diagnosed with a mitral valve murmur. Which information supports this finding?
- The client has a history of rheumatic fever as a child.
- The client takes an oral anticoagulant daily.
- The client has elevated troponin levels.
- The client recently took a vacation to Central America.
Explanation: Answer reason: Rheumatic fever can cause chronic valvular damage from an autoimmune inflammatory response after streptococcal infection, and the mitral valve is most commonly affected. Resulting scarring and leaflet thickening lead to turbulent blood flow, producing a murmur consistent with mitral valve disease (e.g., stenosis or regurgitation). Daily oral anticoagulation may be used for atrial fibrillation or prosthetic valves but does not by itself explain why a murmur is present. Elevated troponin supports myocardial injury/acute coronary syndrome rather than a valvular murmur etiology.
The nurse is providing education for a client with Cushing’s disease. Which of the following information would be important to include?
- Avoid a low-sodium diet.
- Physical changes are disease related.
- High fluid intake is important.
- Restrict protein intake.
Explanation: Answer reason: Cushing’s disease causes chronic excess cortisol, leading to characteristic body changes (e.g., truncal obesity, moon face, buffalo hump, skin fragility, bruising, and muscle weakness). Patient teaching should normalize these findings as manifestations of the endocrine disorder, which supports understanding, adherence, and coping. Teaching about diet in Cushing’s typically emphasizes sodium restriction (to reduce edema/HTN) and adequate protein (to counteract catabolism), making the sodium and protein options unsafe or inaccurate. Encouraging high fluids is not a core teaching point and can be inappropriate if fluid retention and hypertension are present.
A 55-year-old client is admitted with hyperthyroidism. What is the most important nursing intervention?
- Keeping the client warm
- Encouraging the client to increase activity
- Providing a calm, restful environment
- Placing the client in high Fowler’s position
Explanation: Answer reason: Minimizing stimulation and promoting rest reduces sympathetic activation, helps control cardiovascular strain, and supports recovery while medical therapy is initiated. Keeping the client warm is inappropriate because these clients are typically heat intolerant and prone to hyperthermia. Encouraging increased activity would further increase metabolic demand and exacerbate tachycardia and fatigue.
A client is diagnosed with atopic dermatitis. He is upset and asks how to avoid another outbreak. The nurse determines that the client needs information regarding?
- Avoiding bacterial infections.
- Avoiding fungal infections.
- Hereditary factors.
- Avoiding viral infections.
Explanation: Answer reason: Atopic dermatitis is a chronic inflammatory skin disorder with strong genetic/atopic predisposition, and recurrence reflects underlying immune-barrier dysfunction rather than acquisition of a specific infection. Teaching that helps the client understand inherited susceptibility (often associated with family history of eczema, asthma, or allergic rhinitis) addresses why flares recur and sets realistic expectations about long-term management. While secondary infection can complicate lesions, it is typically a consequence of skin breakdown and scratching, not the primary driver of new outbreaks. Therefore, focusing education on hereditary predisposition is the most accurate basis for preventing and managing future flares through trigger control and skin-care routines.
The nurse is implementing interventions for the client who has increased ICP. The nurse knows that which result will occur if the increased ICP is left untreated?
- Displacement of brain tissue
- Increase in cerebral perfusion
- Increase in the serum pH level
- Leakage of cerebrospinal fluid
Explanation: Answer reason: As pressure gradients form between compartments, brain tissue shifts across rigid dural folds or through the foramen magnum, leading to rapid neurologic deterioration and possible death. Increased ICP does not improve cerebral perfusion; it typically lowers cerebral perfusion pressure (CPP = MAP − ICP) and worsens ischemia. CSF leakage and serum pH changes are not the expected direct outcome of untreated increased ICP compared with the life-threatening risk of herniation.
The nurse is teaching a client about angina. Which statement by the nurse would be most accurate regarding the primary treatment goal?
- Reversal of ischemia
- Reversal of infarction
- Reduction of stress and anxiety
- Reduction of associated risk factors
Explanation: Answer reason: Therapies such as rest, nitrates, beta-blockers, and oxygen (when indicated) work by decreasing myocardial oxygen demand and/or improving coronary blood flow, directly addressing ischemia. Infarction implies irreversible myocardial cell death, which is not the defining process in angina and therefore is not the primary goal. Risk-factor modification and anxiety reduction are important long-term adjuncts but do not represent the primary acute treatment target.
Which response should a nurse offer to a client who asks why he’s having a vagotomy to treat his ulcer?
- To repair a hole in the stomach
- To reduce the ability of the stomach to produce acid
- To prevent the stomach from sliding into the chest
- To remove a potentially malignant lesion in the stomach
Explanation: Answer reason: This directly addresses peptic ulcer pathophysiology where excess acid and impaired mucosal defenses contribute to ulcer formation. Repairing a hole describes treatment for a perforated ulcer, not the purpose of vagotomy as an ulcer-reducing procedure. Preventing stomach herniation into the chest relates to hiatal hernia management, and removing a malignant lesion is an oncologic resection rather than an acid-reducing operation.
A 36-year-old client complains of fatigue, weight loss, and a low-grade fever. He also has pain in his fingers, elbows, and ankles. The nurse identifies these symptoms as indicative of?
- Anemia.
- Leukemia.
- Rheumatic arthritis.
- Systemic lupus erythematosus (SLE).
Explanation: Answer reason: A key principle is that systemic autoimmune disease commonly causes constitutional symptoms (fatigue, weight loss, low-grade fever) together with inflammatory, migratory polyarthralgias affecting small and large joints. This symptom cluster fits SLE, which often presents with joint pain/swelling plus chronic systemic inflammation even before more specific findings (rash, renal or hematologic abnormalities) are recognized. Anemia can explain fatigue but does not account for multi-joint inflammatory pain and fever as a primary syndrome. Leukemia can cause fever and fatigue, but prominent symmetric peripheral joint pain is more characteristic of an autoimmune connective-tissue disorder like SLE.
A nurse is working on a medical/surgical unit and notes that one of the client’s assigned has a diagnosis of ankylosing spondylitis. The nurse would assess this client for?
- Red, painful, swollen joints
- Fatigue and night sweats
- Low back pain
- Neck pain and stiffness
Explanation: Answer reason: Clients commonly report insidious onset low back pain with morning stiffness that improves with activity rather than rest. This presentation is more characteristic than peripheral joint erythema/swelling, which is more typical of acute inflammatory arthritis affecting appendicular joints. Cervical involvement can occur later, but early disease classically centers on the low back and sacroiliac region.
The nurse is explaining the process of acute respiratory distress syndrome (ARDS) to a client. What is the best explanation for the nurse to tell the client?
- Alveoli are overexpanded.
- Alveoli increase perfusion.
- Alveolar spaces are filled with fluid.
- Alveoli improve gaseous exchange.
Explanation: Answer reason: ARDS is driven by diffuse inflammatory injury to the alveolar-capillary membrane, increasing permeability and causing noncardiogenic pulmonary edema. Protein-rich fluid and inflammatory debris enter the alveoli, decreasing lung compliance and creating shunt physiology with severe hypoxemia. This directly explains why gas exchange worsens despite oxygen therapy in many cases. Options describing overexpansion or improved gas exchange contradict the hallmark mechanism, and increased perfusion is not the defining problem compared with alveolar flooding and impaired diffusion/ventilation.
A client with a fat embolism continues to be hypoxic following therapy with positive end-expiratory pressure. What is the priority intervention to reduce oxygen demand?
- Give diuretics.
- Give neuromuscular blockers.
- Put the head of the bed flat.
- Use bronchodilators.
Explanation: Answer reason: In refractory hypoxemia despite PEEP, a major driver of worsening oxygenation is high metabolic and ventilatory demand from agitation, dyssynchrony, and excessive work of breathing. Neuromuscular blockade can temporarily eliminate respiratory muscle activity, improve ventilator synchrony, and decrease whole-body oxygen consumption, allowing delivered oxygen to better meet demand while lung injury is managed. Diuretics do not directly lower oxygen demand and are not a primary therapy for fat embolism–related hypoxemia unless fluid overload is present. Bronchodilators target bronchospasm, which is not the key mechanism in fat embolism syndrome, and flattening the bed can worsen ventilation and oxygenation.
The nurse is conducting a preoperative class for clients scheduled for gastric bypass surgery. One of the clients asks the nurse what the most common source of pulmonary embolism is. The most appropriate response by the nurse is?
- Amniotic fluid.
- Bone marrow.
- Septic thrombi.
- Venous thrombi.
Explanation: Answer reason: Pulmonary emboli most commonly arise from thrombi that form in the deep veins (especially of the legs/pelvis) and then embolize to the pulmonary arterial circulation. Bariatric surgery patients are at increased VTE risk due to obesity, perioperative immobility, and the hypercoagulable state associated with major surgery, making DVT the key source to recognize. Amniotic fluid and fat/bone marrow emboli can cause acute pulmonary compromise but are uncommon and occur in specific settings (obstetric catastrophe or long-bone trauma). Septic emboli occur with infected thrombi/endocarditis but are not the most common overall source of PE.
The nurse is caring for a client who is in the latter stages of Reye’s syndrome. What is the most important intervention by the nurse to prevent or reduce cerebral edema?
- Noninvasive pressure monitoring
- Paralysis and sedation
- Liberal fluid replacement
- Nonassisted ventilation
Explanation: Answer reason: Deep sedation with neuromuscular blockade limits agitation, coughing, shivering, and ventilator dyssynchrony, all of which increase intrathoracic pressure and can impair venous drainage from the brain. This strategy also helps maintain controlled ventilation and oxygenation, reducing secondary brain injury. In contrast, liberal fluid replacement can worsen cerebral edema by increasing total body water and capillary hydrostatic pressure, and leaving ventilation nonassisted risks hypoventilation and hypercapnia, which promotes cerebral vasodilation and increases ICP.
The nurse is providing postoperative care to a client with sickle cell anemia. What is the most important intervention for the nurse to include in the plan of care?
- Increasing fluids
- Preparing the child psychologically
- Discouraging coughing
- Limiting the use of analgesics
Explanation: Answer reason: Postoperatively, maintaining adequate hydration helps reduce sickling risk and supports tissue perfusion, lowering the chance of pain crisis and acute chest syndrome. Encouraging coughing is typically important after surgery to prevent atelectasis and pneumonia; discouraging it would increase pulmonary complications. Adequate analgesia is essential because uncontrolled pain triggers stress and hypoventilation, both of which can precipitate sickling-related complications.
Which intervention is indicated for a child in sickle cell vaso-occlusive crisis?
- Immobilizing the affected part
- Applying warm packs to the affected part
- Applying cool packs to the affected part
- Performing active range-of-motion (ROM) exercises to the affected part
Explanation: Answer reason: Local heat promotes vasodilation and can help increase blood flow to the painful area while providing comfort. Cold causes vasoconstriction, which can worsen ischemia and intensify pain in this setting. During acute crisis, aggressive activity like active ROM can exacerbate pain; comfort measures and supportive therapies are prioritized.
The nurse is performing a physical assessment on a client. The nurse asks the client to flex the neck. The neck flexion results in flexion of the hip and knee which is known as Brudzinski’s sign. Which condition is associated with Brudzinski’s sign?
- Meningitis.
- Peritonsillar abscess.
- Pharyngitis.
- Rhinosinusitis.
Explanation: Answer reason: Brudzinski’s sign reflects meningeal irritation from inflammation of the meninges, producing involuntary hip and knee flexion with passive neck flexion to reduce stretch on inflamed tissues. This finding is classically associated with acute meningitis (bacterial or viral) and is assessed alongside other meningeal signs and symptoms such as nuchal rigidity, headache, fever, and photophobia. Infections limited to the upper airway (pharyngitis, rhinosinusitis) or peritonsillar space typically cause sore throat and localized ENT findings rather than reflex posturing with neck flexion. Therefore the condition most directly linked to this neurologic exam sign is meningitis.
A client is admitted to the medical floor with a diagnosis of pancreatitis. Which of the following nursing interventions is the priority?
- Maintain oral intake and avoid analgesics.
- Control pain and maintain NPO status.
- Allow client to dictate food and alcohol servings.
- Support surgical management interventions.
Explanation: Answer reason: Acute pancreatitis causes pancreatic inflammation and severe abdominal pain, and pancreatic stimulation worsens enzyme activation and tissue injury. Keeping the client NPO provides “pancreatic rest,” reducing exocrine secretion and helping limit progression of inflammation while other therapies (IV fluids, antiemetics) are started. Adequate analgesia is a priority because uncontrolled pain increases sympathetic stress, can impair ventilation, and worsens overall physiologic instability. A key distractor is encouraging oral intake, which increases pancreatic stimulation and is inappropriate early in acute pancreatitis; routine surgical management is not the initial priority unless complications mandate it.
A nurse is teaching a client about atherosclerosis. The nurse determines further teaching is necessary when the client makes which of the following statements?
- Plaques obstruct the coronary artery.
- Plaques obstruct the vein.
- Hardened vessels can’t dilate to allow blood to flow through.
- Atherosclerosis can cause angina.
Explanation: Answer reason: Atherosclerosis is a disease of arteries characterized by lipid-rich plaque formation within the arterial intima, leading to luminal narrowing and reduced tissue perfusion. Describing plaque obstruction as occurring in veins reflects confusion with venous disorders (e.g., thrombosis), not atherosclerotic plaque. The other statements align with arterial plaque reducing coronary blood flow, limiting vasodilation/elasticity, and producing myocardial ischemia manifested as angina. Therefore, the vein statement indicates misunderstanding and a need for further teaching.
A client is admitted to the unit with intermittent claudication. Which of the following responses by the nurse would most accurately explain the cause of the condition to the client?
- Inadequate blood supply
- Elevated leg position
- Dependent leg position
- Inadequate muscle oxygenation
Explanation: Answer reason: Peripheral arterial disease limits perfusion, so working muscles switch to anaerobic metabolism, producing pain/cramping that improves with rest as demand falls. This mechanism is best described as reduced oxygen delivery to the muscle tissue rather than a positioning problem. “Elevated” or “dependent” leg positions may change symptoms transiently, but they are not the underlying cause of the condition.
A client was infected with tuberculosis (TB) bacillus 10 years ago but never developed the disease. He’s now being treated for cancer. The client begins to develop signs of TB. The nurse suspects the client is exhibiting?
- Active infection.
- Latent infection.
- Superinfection.
- Tertiary infection.
Explanation: Answer reason: Immunosuppression (e.g., from cancer therapy) can allow reactivation of previously contained TB organisms, converting an asymptomatic state into symptomatic disease. The key clue is that the client is now developing signs of TB, which indicates active disease rather than mere infection without symptoms. Latent TB implies no clinical manifestations and non-contagious status, whereas reactivation produces symptomatic illness and potential infectiousness. “Superinfection” and “tertiary infection” are not appropriate descriptors for TB reactivation in this context.
A firefighter is being treated for smoke inhalation. He develops severe hypoxia 48 hours later, requiring intubation and mechanical ventilation. The nurse determines that the client is experiencing?
- Acute respiratory distress syndrome (ARDS).
- Atelectasis.
- Bronchitis.
- Pneumonia.
Explanation: Answer reason: Smoke inhalation can trigger a delayed inflammatory lung injury with increased alveolar-capillary permeability, leading to noncardiogenic pulmonary edema and profound refractory hypoxemia. The 24–48 hour time course with rapid deterioration requiring intubation and mechanical ventilation is classic for this syndrome. This process causes diffuse alveolar collapse and shunt physiology, so oxygenation becomes difficult despite supplemental oxygen. Atelectasis can worsen oxygenation but is usually more focal and often improves with lung expansion maneuvers rather than progressing to severe ventilatory failure, and bronchitis is unlikely to cause such profound hypoxia so quickly without other signs.
A client has been diagnosed with a pulmonary embolism and begins to experience chest pain. The client asks the nurse what is causing the pain. The most appropriate response by the nurse is?
- Costochondritis.
- Myocardial infarction (MI).
- Inflammatory reaction.
- Referred pain from the pelvis to the chest.
Explanation: Answer reason: Pleuritic chest pain with a pulmonary embolism is typically caused by pulmonary infarction and irritation of the pleura, which triggers an acute inflammatory response. This inflammation stimulates pain fibers in the pleural surfaces, producing sharp pain that often worsens with deep inspiration or coughing. An MI can also cause chest pain, but it is a separate cardiac ischemic process and does not explain PE-related pleural irritation as the primary mechanism. Costochondritis is musculoskeletal chest wall inflammation and is not the expected cause in the setting of an acute embolic event.
A client with a pulmonary embolism tells the nurse that he feels a sense of “impending doom.” The nurse recognizes that this manifestation is caused by what?
- Inflammatory reaction in the lung parenchyma
- Loss of chest expansion
- Loss of lung tissue
- Sudden reduction in adequate oxygenation
Explanation: Answer reason: Acute hypoxemia and the resulting sympathetic surge (tachycardia, anxiety, catecholamine release) commonly produce the subjective sensation of intense anxiety or “impending doom.” This finding reflects an immediate physiologic threat from impaired oxygen delivery rather than structural loss of lung tissue. Inflammation of the parenchyma is more characteristic of pneumonia and does not typically cause this sudden, dramatic symptom onset.
A nurse is observing an infant with thyroid hormone deficiency. Which signs would the nurse commonly observe?
- Tachycardia, profuse perspiration, and diarrhea
- Lethargy, feeding difficulties, and constipation
- Hypertonia, small fontanels, and moist skin
- Dermatitis, dry skin, and round face
Explanation: Answer reason: Reduced energy and poor neuromuscular tone also contribute to weak feeding and overall lethargy. In contrast, tachycardia, sweating, and diarrhea are classic hyperthyroid findings due to increased metabolic activity. The key nursing cue is the cluster of “slowed” physiologic functions consistent with hypothyroidism.
During an initial nursing assessment, a nurse determines that an 8-year-old child has right lower quadrant pain, a low-grade fever, nausea, rebound tenderness, and a positive psoas sign. The nurse suspects that the client has which condition?
- Appendicitis
- Gastroenteritis
- Pancreatitis
- Cholecystitis
Explanation: Answer reason: A positive psoas sign supports appendiceal inflammation, especially when the appendix is retrocecal and irritates the iliopsoas muscle during hip movement. Nausea commonly accompanies the evolving inflammatory process. In contrast, gastroenteritis typically causes diffuse crampy abdominal pain with prominent diarrhea rather than focal RLQ tenderness and peritoneal signs.
The nurse is caring for a client in stage V of Reye’s syndrome. The nurse documents which assessment data?
- Vomiting, lethargy, and drowsiness
- Seizures, flaccidity, and respiratory arrest
- Hyperventilation and coma
- Disorientation, aggressiveness, and combativeness
Explanation: Answer reason: This produces profound neurologic deterioration with seizures progressing to decorticate/decerebrate changes, loss of motor tone (flaccidity), and ultimately apnea/respiratory arrest. Earlier stages are characterized by vomiting/lethargy (stage I), irritability or disorientation (stages II–III), and coma with abnormal respirations such as hyperventilation (stage IV). Therefore, the findings reflecting terminal neurologic and respiratory collapse best match stage V.
Which clinical manifestation would the nurse assess in the client with a T-12 spinal cord injury (SCI) who is experiencing spinal shock?
- Flaccid paralysis below the waist.
- Lower extremity muscle spasticity.
- Complaints of a pounding headache.
- Hypertension and bradycardia.
Explanation: Answer reason: Spinal shock is the acute phase after a spinal cord injury characterized by transient loss of all neurologic activity below the level of injury, including areflexia and flaccid motor tone. With a T12 SCI, findings would primarily involve the lower extremities, producing flaccid paralysis below the lesion early on. Spasticity is typical later, after spinal shock resolves and upper motor neuron signs emerge. Headache with hypertension and bradycardia suggests autonomic dysreflexia, which is usually associated with injuries at or above T6 rather than T12 and is not the defining presentation of spinal shock.
The nurse is caring for a client with an opportunistic infection of the central nervous system. The nurse knows that opportunistic infections affecting the central nervous system are extremely likely once the CD4 count drops below which level?
- < 50/mm3.
- < 75/mm3.
- > 200/mm3.
- > 200/mm3.
Explanation: Answer reason: Opportunistic CNS infections in advanced HIV/AIDS correlate with profound cellular immunosuppression, and the risk rises sharply as CD4 counts fall to very low levels. Many severe opportunistic pathogens (e.g., CMV disease and some CNS presentations) are most strongly associated with CD4 counts below 50 cells/mm3, reflecting minimal T-cell–mediated defense. By contrast, a CD4 threshold of 200 cells/mm3 is classically tied to risks like Pneumocystis jirovecii pneumonia rather than being the point at which CNS opportunistic infections are “extremely likely.” Therefore, the lowest CD4 threshold offered best matches the level at which these infections become highly probable and clinically expected.
A nurse is caring for a client recently diagnosed with acute pancreatitis. Which statement indicates that a short-term goal of nursing care has been met?
- The client denies abdominal pain.
- The client doesn’t complain of thirst.
- The client denies pain at McBurney’s point.
- The client swallows liquids without coughing.
Explanation: Answer reason: Acute pancreatitis commonly causes significant epigastric/upper abdominal pain, and a primary short-term nursing goal is relief of pain and improved comfort. A client report of no abdominal pain directly reflects effective management of the acute inflammatory process and/or analgesic and supportive interventions. Absence of thirst is not a reliable pancreatitis outcome indicator because thirst can be influenced by many factors and pancreatitis can involve fluid shifts and dehydration. Lack of pain at McBurney’s point is more consistent with ruling out appendicitis, and swallowing liquids without coughing relates to aspiration risk rather than pancreatitis goals.
An adolescent client ingests a large number of acetaminophen (Tylenol) tablets in an attempt to commit suicide. Which laboratory result is most consistent with acetaminophen overdose?
- Metabolic acidosis
- Elevated liver enzyme levels
- Increased serum creatinine level
- Increased white blood cell (WBC) count
Explanation: Answer reason: This injury classically produces rising aminotransferases (AST/ALT), often within 24–72 hours, and is a key lab indicator of toxicity severity. Metabolic acidosis can occur in massive overdose or late hepatic failure but is not the most typical early hallmark compared with transaminitis. Creatinine may rise if renal injury occurs, and WBC elevation is nonspecific and not characteristic of this toxidrome.
The nurse is admitting a new client with a diagnosis of myxedema. During the initial assessment, the nurse is most concerned when the client presents with which findings?
- Hypertension and weight loss
- Heat intolerance and emotional lability
- Corneal ulcerations and increased appetite
- Bradycardia and decreased intellectual function
Explanation: Answer reason: A low heart rate signals reduced cardiac output and risk for hypotension, hypothermia, and progression toward myxedema coma, making it a high-priority assessment finding. Cognitive slowing/mental status changes also indicate significant CNS depression and can be an early warning of decompensation. In contrast, heat intolerance, emotional lability, weight loss, and increased appetite are more consistent with hyperthyroidism rather than myxedema.
The nurse is reviewing the diagnoses of her assigned clients and notes that one of the clients has Cushing’s syndrome. The nurse is aware that this client is at risk for which of the following?
- Hypoglycemia and dehydration
- Hypotension and hyperglycemia
- Hyponatremia and dehydration
- Hypertension and heart failure
Explanation: Answer reason: This volume expansion raises blood pressure and increases cardiac workload, predisposing to fluid overload and congestive heart failure. Cortisol also increases vascular sensitivity to catecholamines, further contributing to hypertension. In contrast, hypotension and hyponatremia are more consistent with adrenal insufficiency rather than cortisol excess.
A client is in diabetic ketoacidosis, secondary to infection. As the condition progresses, which symptoms might the nurse see?
- Kussmaul’s respirations and a fruity odor on the breath
- Shallow respirations and severe abdominal pain
- Decreased respirations and increased urine output
- Cheyne-Stokes respirations and foul-smelling urine
Explanation: Answer reason: The body compensates by increasing depth and rate of breathing (Kussmaul respirations) to blow off CO2 and raise pH. Volatile ketones (especially acetone) produce a characteristic fruity breath odor as ketosis worsens. Choices describing decreased/shallow respirations conflict with the expected respiratory compensation, and Cheyne-Stokes is more associated with severe neurologic/cardiac instability rather than typical DKA progression.
The nurse is caring for the client with elevated growth hormone (GH) levels. Which problem should the nurse exclude from the plan of care?
- Fluid volume deficit due to polyuria
- Insomnia due to soft tissue swelling
- Impaired communication due to speech difficulties
- Altered body image due to undersized hands, feet, and jaw
Explanation: Answer reason: Therefore, a body-image problem would be related to enlarged, not undersized, features, making this option inconsistent with the condition and appropriate to exclude. Elevated GH can also contribute to glucose intolerance and diaphoresis, and mass effects can contribute to complications that affect sleep and communication. A common distractor is focusing on “hands/feet/jaw” while missing that the direction of change is opposite of what occurs with GH excess.
The client is admitted with a diagnosis of colon cancer. Which finding in the client’s admission information should prompt the nurse to consider that the cancer may be located in the client’s descending colon?
- Pain in the lower abdomen
- Change in bowel habits
- Bright red blood in the stool
- Nausea and vomiting
Explanation: Answer reason: This “obstructive” pattern is a classic localization clue for distal colon cancer compared with right-sided lesions, which more often cause occult bleeding and iron-deficiency anemia. Bright red blood can occur with distal sources but is less specific because hemorrhoids and rectal lesions also cause it. Nausea and vomiting are more consistent with more advanced obstruction and are not a key early localization finding.
A client is admitted with right lower quadrant pain, anorexia, nausea, lowgrade fever, and elevated white blood cell count. Based on these assessments, which of the following complications is the client most likely experiencing?
- A fecalith
- Bowel kinking
- Internal bowel occlusion
- Abdominal wall swelling
Explanation: Answer reason: The most common initiating mechanism is luminal obstruction of the appendix, classically by a fecalith, which leads to bacterial overgrowth, inflammation, and localized peritoneal irritation. This mechanism fits the systemic inflammatory findings (fever, elevated WBC) better than mechanical problems like postoperative kinking. General bowel occlusion would more typically present with diffuse cramping, vomiting, distention, and obstipation rather than localized RLQ tenderness and inflammatory signs.
A client with chronic gastritis asks why they need to have injections of vitamin B12. Which response by the nurse is most appropriate?
- “Your white blood cell count is low.”
- “It will give you more energy.”
- “Your condition does not allow vitamin B12 to be absorbed.”
- “It is necessary for people with this disorder.”
Explanation: Answer reason: Chronic gastritis can damage gastric parietal cells and reduce intrinsic factor production, which is required for vitamin B12 absorption in the terminal ileum. When absorption is impaired, oral replacement may be ineffective, so parenteral administration bypasses the GI tract. This teaching directly explains the mechanism and the reason injections are needed. The low energy statement is nonspecific and symptom-focused, and the WBC statement is not the typical deficiency effect (B12 deficiency primarily causes macrocytic anemia and possible neurologic changes).
A client complains of low back pain that radiates down the right leg, with numbness and weakness of the right leg. Based on the subjective data, the nurse recognizes these complaints as related to which disorder?
- Herniated nucleus pulposus
- Muscular dystrophy
- Parkinson’s disease
- Osteoarthritis
Explanation: Answer reason: A herniated intervertebral disc can protrude and compress a spinal nerve root, producing dermatomal pain and neurologic deficits such as sensory loss and decreased strength. Osteoarthritis more often causes localized joint/back pain and stiffness without a sharp radicular pattern with focal neurologic findings. Muscular dystrophy and Parkinson’s disease cause progressive generalized motor issues rather than acute unilateral radicular pain with sensory symptoms.
A client with a T1 spinal cord injury arrives at the emergency department with a blood pressure of 82/40 mm Hg, pulse of 34 beats/minute, dry skin, and flaccid paralysis of the lower extremities. Which condition should be suspected?
- Autonomic dysreflexia
- Hypervolemia
- Neurogenic shock
- Sepsis
Explanation: Answer reason: This produces hypotension with marked bradycardia and often warm/dry skin from impaired sympathetic-mediated sweating and vasoconstriction. The presentation fits neurogenic shock rather than autonomic dysreflexia, which classically causes severe hypertension with reflex bradycardia. Sepsis typically causes tachycardia and signs of infection, and hypervolemia would not explain profound bradycardia with distributive hypotension after spinal cord injury.
After a motor vehicle collision, a client has a chest tube inserted in the left upper chest. The tube begins to drain a large amount of dark red fluid. The nurse determines that?
- The chest tube was inserted improperly.
- This is an expected result.
- An artery was nicked when the chest tube was placed.
- The client is experiencing a hemothorax.
Explanation: Answer reason: Large-volume, dark red drainage from a chest tube after blunt chest trauma most strongly indicates blood accumulating in the pleural space. A chest tube placed for traumatic chest injury can evacuate air or blood; when the output is frank/bloody and substantial, hemothorax is the most direct, clinically meaningful interpretation. This finding is not an expected baseline outcome because excessive sanguineous output signals ongoing intrathoracic bleeding requiring prompt assessment and potential escalation. While a vessel injury from insertion is possible, trauma-related pleural bleeding is the more likely and testable determination based on the presentation.
A client who is scheduled for a pneumonectomy asks the nurse how thoracic cavity will be filled. The best response by the nurse would be?
- The space remains filled with air only.
- The surgeon fills the space with a gel.
- Serous fluid fills the space and consolidates the region.
- The tissue from the other lung grows over to the other side.
Explanation: Answer reason: After removal of an entire lung, the empty hemithorax does not stay as an air-filled void because the postpneumonectomy space gradually accumulates sterile serous fluid. This progressive fluid fill and mediastinal shift stabilize intrathoracic pressures and helps prevent excessive dead space over time. Leaving the space “filled with air only” would imply a persistent large pneumothorax-like cavity, which is not the expected longer-term physiologic course. The remaining lung compensates mainly by hyperinflation and improved function rather than physically growing across to replace the removed lung.
The nurse assesses the client in her third trimester with suspected placenta previa. Which findings should the nurse associate with placenta previa?
- Cervix is 100% effaced
- Painless vaginal bleeding
- The fetal lie is transverse
- Absence of fetal movement
Explanation: Answer reason: The classic presentation is sudden, bright red bleeding without uterine tenderness or pain because the bleeding is not caused by abruption-related myometrial irritation. A transverse or abnormal lie can be associated with placenta previa, but it is less specific than the hallmark bleeding and may be seen in other conditions. Cervical effacement and absent fetal movement are not defining findings for placenta previa and would prompt evaluation for labor progression or fetal compromise rather than being characteristic features.
The nurse is caring for a postoperative client who has undergone removal of the pituitary gland and tumor (hypophysectomy). The nurse is aware that the client may be at risk for?
- Hypernatremia and concentrated urine.
- Dilute urine with a low specific gravity.
- Hyponatremia and concentrated urine.
- Dilute urine with a high specific gravity.
Explanation: Answer reason: Removal or trauma to the pituitary can reduce antidiuretic hormone (ADH) secretion, placing the client at risk for central diabetes insipidus. With inadequate ADH, the kidneys cannot concentrate urine, leading to polyuria with very dilute urine and a low urine specific gravity. Ongoing free-water losses also increase risk for dehydration and rising serum osmolality (often hypernatremia), but the key urine finding is dilute output. Options describing concentrated urine or high specific gravity are inconsistent with the expected post-hypophysectomy ADH deficiency pattern.
The nurse is caring for a client who has experienced a cerebral vascular accident. The client is displaying oliguria and hyponatremia. The nurse suspects which of the following disorders?
- Thyrotoxic crisis
- Diabetes insipidus
- Primary adrenocortical insufficiency
- Syndrome of inappropriate antidiuretic hormone (SIADH)
Explanation: Answer reason: The retained free water expands intravascular volume and reduces urine output, explaining oliguria. In contrast, diabetes insipidus after CNS injury causes impaired ADH effect leading to polyuria and hypernatremia, the opposite pattern. Thyrotoxic crisis presents with hypermetabolic findings (fever, tachycardia) rather than dilutional hyponatremia with low urine output, and primary adrenal insufficiency typically causes hypotension and hyperkalemia with volume depletion.
A 20-year-old client developed osteomyelitis 2 weeks after a fishhook was removed from the client’s foot. Which rationale best explains the expected long-term antibiotic therapy needed?
- Bone has poor circulation.
- Tissue trauma requires antibiotics.
- Feet are normally more difficult to treat.
- Fishhook injuries are highly contaminated.
Explanation: Answer reason: Osteomyelitis often requires prolonged antibiotics because infected bone is relatively poorly perfused compared with soft tissue, limiting immune cell access and reducing antibiotic delivery to the site. Necrotic bone and sequestra can further isolate bacteria, making eradication slow and increasing relapse risk if treatment is too short. Therefore, extended therapy is needed to maintain adequate tissue drug levels over time to penetrate the infected bone and suppress residual organisms. In contrast, contamination from a fishhook may explain how infection started, but it does not by itself account for the long duration of therapy once infection is established in bone.
A client with chronic obstructive bronchitis asks the nurse why he is receiving diuretic therapy. What is the best response by the nurse?
- Reducing fluid volume reduces oxygen demand.
- Reducing fluid volume improves clients’ mobility.
- Reducing fluid volume reduces sputum production.
- Reducing fluid volume improves respiratory function.
Explanation: Answer reason: Diuretics are used to decrease intravascular volume and edema, which can reduce pulmonary vascular congestion and the work of breathing in clients who develop cor pulmonale or fluid overload with chronic bronchitis. Lower circulating volume decreases right-sided heart strain and can lessen peripheral and pulmonary fluid accumulation that worsens gas exchange. This leads to improved ventilation/perfusion matching and easier respiratory mechanics. By contrast, sputum production is primarily related to airway inflammation and mucus hypersecretion, not total body fluid volume, so volume reduction is not the direct mechanism for that outcome.
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