Medication Administration Practice Test 4
Medication Administration NCLEX Practice Test
Medication Administration is a key topic within the NCLEX test plan, located under Physiological Integrity → Pharmacological and Parenteral Therapies → Medication Administration. This section applies the rights of medication safety and patient education for optimal outcomes. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 4th part of the Medication Administration series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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Medication Administration Practice Test 4
The physician has prescribed Synthroid (levothyroxine) for a client with myxedema. Which statement indicates that the client understands the nurse’s teaching regarding the medication?
- I will take the medication each morning after breakfast.
- I will check my heart rate before taking the medication.
- I will report visual disturbances to my doctor.
- I will stop the medication if I develop gastric upset.
Explanation: Answer reason: Levothyroxine can cause tachycardia; clients are taught to monitor their pulse before dosing and report elevated rates. It should be taken before breakfast (not after), visual disturbances are not typical, and the drug should not be stopped for mild GI upset.
An adolescent with cystic fibrosis has an order for pancreatic enzyme replacement. The nurse knows that the medication should be given?
- At bedtime
- With meals and snacks
- Twice daily
- Daily in the morning
Explanation: Answer reason: Pancreatic enzymes in cystic fibrosis must be taken with all meals and snacks to aid digestion and nutrient absorption; not given just at bedtime, twice daily, or only in the morning.
A client with diabetes mellitus has a prescription for Glucotrol XL (glipizide). The client should be instructed to take the medication?
- At bedtime
- With breakfast
- Before lunch
- After dinner
Explanation: Answer reason: Glipizide XL is an extended-release sulfonylurea taken once daily with the first main meal—typically breakfast—to optimize glycemic control and reduce hypoglycemia risk.
The physician has ordered Vancocin (vancomycin) 500mg IV every 6 hours for a client with MRSA. The medication should be administered?
- IV push
- Over 15 minutes
- Over 30 minutes
- Over 60 minutes
Explanation: Answer reason: Vancomycin must be infused slowly—at least 60 minutes—to prevent hypotension and red man syndrome; never given IV push.
A client with Addison's disease asks the nurse what he needs to know to manage his condition. The nurse should give priority to?
- Emphasizing the need for strict adherence to his medication regimen
- Teaching the client to avoid lotions and skin preparations containing alcohol
- Explaining the need to avoid extremes of temperature
- Assisting the client to choose a diet that contains adequate protein, fat, and carbohydrates
Explanation: Answer reason: Addison's disease requires lifelong glucocorticoid/mineralocorticoid replacement; strict adherence prevents adrenal crisis. Therefore education on maintaining the medication regimen is the priority.
The nurse calculates the amount of an antibiotic for injection to be given to an infant. The amount of medication to be administered is 1.25mL. The nurse should?
- Divide the amount into two injections and administer in each vastus lateralis muscle
- Give the medication in one injection in the dorsogluteal muscle
- Divide the amount into two injections and give one in the ventrogluteal muscle and one in the vastus lateralis muscle
- Give the medication in one injection in the ventrogluteal muscle
Explanation: Answer reason: For infants, the preferred IM site is the vastus lateralis; dorsogluteal is contraindicated. A 1.25 mL dose exceeds typical single-site infant volumes, so the dose should be split and administered in both vastus lateralis muscles.
A client with schizophrenia is receiving depot injections of Haldol Decanoate (haloperidol decanoate). The client should be told to return for his next injection in?
- 1 week
- 2 weeks
- 4 weeks
- 6 weeks
Explanation: Answer reason: Haloperidol decanoate is a long-acting depot antipsychotic typically administered intramuscularly every 4 weeks (monthly) for maintenance therapy.
The nurse is preparing to give an oral potassium supplement. The nurse should give the medication?
- Without diluting it
- With 4oz. of juice
- With water only
- On an empty stomach
Explanation: Answer reason: Liquid oral potassium is irritating to the GI tract and should be diluted in at least 4 oz of water or fruit juice and given with/after food. Therefore giving it with 4 oz of juice is the safest option among those listed.
The physician has ordered cortisporin ear drops for a 2-year-old. To administer the ear drops, the nurse should?
- Pull the ear down and back
- Pull the ear straight out
- Pull the ear up and back
- Leave the ear undisturbed
Explanation: Answer reason: For children under 3 years, straighten the ear canal by pulling the pinna down and back before instilling otic drops. Up and back is for adults/older children; other options are incorrect.
A 6-month-old is being treated for thrush with Nystatin (mycostatin) oral suspension. The nurse should administer the medication by?
- Placing it in a small amount of applesauce
- Using a cotton-tipped swab
- Adding it to the infant's formula
- Placing it in 2–3oz. of water
Explanation: Answer reason: For infant oral thrush, nystatin should be applied directly to the oral mucosa to coat lesions. Using a cotton-tipped swab ensures contact time; mixing with food or liquids dilutes the drug and reduces effectiveness.
A client with iron-deficiency anemia is taking an oral iron supplement. The nurse should tell the client to take the medication with?
- Orange juice
- Water only
- Milk
- Apple juice
Explanation: Answer reason: Vitamin C and an acidic environment enhance absorption of oral iron; orange juice is preferred. Milk decreases absorption, and water or apple juice are less effective.
Which medicine is administered sublingually?
- Nitroglycerin
- Aspirin
- Clopidrogel
- None of these
Explanation: Answer reason: Nitroglycerin tablets are given sublingually for rapid absorption and onset in acute angina; aspirin and clopidogrel are typically administered orally and not sublingually.
What is the correct angle used for giving an intramuscular (IM) injection?
- 45 degree
- 90 degree
- 30 degree
- 60 degree
Explanation: Answer reason: IM injections are inserted at a 90° angle to reach the muscle; 45° is typically for subcutaneous and 30° for intradermal injections.
In the intra-articular route of drug administration, the injection is given into which site?
- Arteries
- Atria
- Joints
- Areolar tissue
Explanation: Answer reason: Intra-articular literally means within a joint; drugs are injected into the synovial joint space.
What are the common sites for intradermal injections?
- Anterior aspect of forearm
- Upper chest
- Upper back
- All of the above
Explanation: Answer reason: Intradermal injections are commonly given on lightly pigmented, hairless areas such as the inner forearm, upper chest, and upper back; therefore all listed sites are correct.
The nurse is preparing to administer digoxin 0.25 mg IVP to a client in severe congestive heart failure who is receiving D5W/0.9 NaCl at 25 mL/hr. Rank in order of importance?
- Administer the medication over 5 minutes.
- Dilute the medication with normal saline.
- Draw up the medication in a tuberculin syringe.
- Check the client’s identification band.
- Clamp the primary tubing distal to the port.
Explanation: Answer reason: Verifying the patient’s identity is the first priority before any medication preparation or administration to ensure the right patient receives the drug.
What is the recommended storage temperature for the polio vaccine?
- 36°C
- -20°C
- 4°C
- 16°C
Explanation: Answer reason: Oral polio vaccine is stored frozen to maintain potency; the cold-chain recommendation is -20°C.
Which muscle is commonly used for injection in the shoulder?
- Bicep Muscle
- Deltoid Muscle
- Tricep Brachial Muscle
Explanation: Answer reason: The deltoid muscle is the standard site for intramuscular injections in the shoulder, especially vaccines; biceps and triceps are not routine IM injection sites.
Which coded instruction is used when a drug is to be given at bedtime?
- Ac
- Hs
- Od
- Sos
Explanation: Answer reason: Hs means hora somni (at bedtime). ac = before meals; od = once daily/right eye; sos = if necessary.
Through which route are immunoglobulins administered?
- Intravenous
- Intramuscular
- Hypodermal
Explanation: Answer reason: Standard immune globulin preparations used for passive immunization (e.g., tetanus, rabies, hepatitis B) are administered intramuscularly; IV use is specific to IVIG formulations.
By which routes are killed vaccines administered?
- Intravenous or intramuscular
- Subcutaneously or intramuscularly
- Hypodermal
Explanation: Answer reason: Inactivated (killed) vaccines are administered via parenteral routes such as subcutaneous or intramuscular injection; they are not given intravenously.
How many times should a nurse check the prescription before administering medicine to a patient?
- One time
- Two time
- Three time
- Four time
Explanation: Answer reason: Nurses perform three checks of the medication/prescription against the MAR: when retrieving, when preparing, and at the bedside before administration.
The client has an order for heparin to prevent post-surgical thrombi. Immediately following a heparin injection, the nurse should?
- Aspirate for blood
- Check the pulse rate
- Massage the site
- Check the site for bleeding
Explanation: Answer reason: Heparin is an anticoagulant; after a subcutaneous injection the priority is to assess for bleeding/hematoma at the site. Do not aspirate or massage.
Before administering Methyltrexate orally to the client with cancer, the nurse should check the?
- IV site
- Electrolytes
- Blood gases
- Vital signs
Explanation: Answer reason: For oral methotrexate, the nurse should complete basic pre-administration assessment; checking vital signs is appropriate. The IV site is irrelevant for an oral drug, and routine checks of electrolytes or blood gases are not specifically required before administering the dose.
The nurse is teaching a group of new graduates about the safety needs of the client receiving chemotherapy. Before administering chemotherapy, the nurse should?
- Administer a bolus of IV fluid
- Administer pain medication
- Administer an antiemetic
- Allow the patient a chance to eat
Explanation: Answer reason: Premedication with an antiemetic is standard before chemotherapy to prevent nausea and vomiting. Routine IV bolus or pain medication is not indicated for all chemotherapy regimens, and eating beforehand may worsen nausea.
A client with osteomyelitis has an order for a trough level to be done because he is taking Gentamycin. When should the nurse call the lab to obtain the trough level?
- Before the first dose
- 30 minutes before the fourth dose
- 30 minutes after the first dose
- 30 minutes before the first dose
Explanation: Answer reason: Trough levels for aminoglycosides like gentamicin are drawn just before the next dose once steady state is reached—typically 30 minutes before the fourth dose.
A new diabetic is learning to administer his insulin. He receives 10U of NPH and 12U of regular insulin each morning. Which of the following statements reflects understanding of the nurse's teaching?
- When drawing up my insulin, I should draw up the regular insulin first.
- When drawing up my insulin, I should draw up the NPH insulin first.
- It doesn't matter which insulin I draw up first.
- I cannot mix the insulin, so I will need two shots.
Explanation: Answer reason: When mixing insulins, draw up the clear (regular) insulin first, then the cloudy (NPH) to avoid contaminating regular insulin with protamine.
The client is taking prednisone 7.5mg po each morning to treat his systemic lupus erythematosis. Which statement best explains the reason for taking the prednisone in the morning?
- There is less chance of forgetting the medication if taken in the morning.
- There will be less fluid retention if taken in the morning.
- Prednisone is absorbed best with the breakfast meal.
- Morning administration mimics the body's natural secretion of corticosteroid.
Explanation: Answer reason: Glucocorticoids follow a circadian rhythm; dosing in the morning best matches endogenous cortisol secretion, reducing adrenal suppression and side effects. Other choices do not explain the timing rationale.
The 10-year-old is being treated for asthma. Before administering Theodur, the nurse should check the?
- Urinary output
- Blood pressure
- Pulse
- Temperature
Explanation: Answer reason: Theo-Dur (theophylline) can cause tachycardia and dysrhythmias; assess the pulse before administration.
The doctor orders 2% nitroglycerin ointment in a 1-inch dose every 12 hours. Proper application of nitroglycerin ointment includes?
- Rotating application sites
- Limiting applications to the chest
- Rubbing it into the skin
- Covering it with a gauze dressing
Explanation: Answer reason: Nitroglycerin ointment should be applied to hairless skin using applicator paper and sites should be rotated to prevent skin irritation and ensure consistent absorption. It is not limited to the chest, should not be rubbed in, and gauze may absorb the drug.
The client is admitted with a BP of 210/100. Her doctor orders furosemide (Lasix) 40mg IV stat. How should the nurse administer the prescribed furosemide to this client?
- By giving it over 1–2 minutes
- By hanging it IV piggyback
- With normal saline only
- With a filter
Explanation: Answer reason: Furosemide IV push should be administered slowly to prevent ototoxicity—about 20 mg per minute; therefore a 40 mg dose is given over 1–2 minutes. It does not require a filter or IVPB.
The physician has ordered sodium warfarin for the client with thrombophlebitis. The order should be entered to administer the medication at?
- 0900
- 1200
- 1700
- 2100
Explanation: Answer reason: Warfarin is typically given in the late afternoon/evening so that morning PT/INR results can be used to adjust the dose the same day. Of the options, 1700 is most appropriate.
To ensure safety while administering a nitroglycerine patch, the nurse should?
- Wear gloves while applying the patch.
- Shave the area where the patch will be applied.
- Wash the area thoroughly with soap and rinse with hot water.
- Apply the patch to the buttocks.
Explanation: Answer reason: Gloves prevent transdermal absorption of nitroglycerin by the nurse, avoiding headaches and hypotension. Shaving can abrade skin, hot water increases vasodilation and absorption, and the buttocks is not a preferred site for nitroglycerin patches.
The nurse has an order for medication to be administered intrathecally. The nurse is aware that medications will be administered by which method?
- Intravenously
- Rectally
- Intramuscularly
- Into the cerebrospinal fluid
Explanation: Answer reason: Intrathecal administration delivers medication directly into the subarachnoid space/CSF, not IV, IM, or rectal routes.
The nurse is visiting a home health client with osteoporosis. The client has a new prescription for alendronate (Fosamax). Which instruction should be given to the client?
- Rest in bed after taking the medication for at least 30 minutes.
- Avoid rapid movements after taking the medication.
- Take the medication with water only.
- Allow at least 1 hour between taking the medicine and taking other medications.
Explanation: Answer reason: Alendronate should be taken first thing in the morning with a full glass of plain water only; other liquids or foods reduce absorption and increase esophageal irritation risk. The client should remain upright for at least 30 minutes; therefore A and B are incorrect, and D is less accurate than the standard 30-minute separation.
The nurse is caring for a 6-year-old client admitted with the diagnosis of conjunctivitis. Before administering eyedrops, the nurse should recognize that it is essential to consider which of the following?
- The eye should be cleansed with warm water, removing any exudate, before instilling the eyedrops.
- The child should be allowed to instill his own eyedrops.
- Allow the mother to instill the eyedrops.
- If the eye is clear from any redness or edema, the eyedrops should be held.
Explanation: Answer reason: Before administering ophthalmic medication for conjunctivitis, any crusting/exudate should be removed with warm water so the drops contact the conjunctiva effectively. A 6-year-old should not self-administer; holding ordered drops due to lack of visible redness is inappropriate.
The physician has ordered Amoxil (amoxicillin) 500mg capsules for a client with esophageal varices. The nurse can best care for the client's needs by?
- Giving the medication as ordered
- Providing extra water with the medication
- Giving the medication with an antacid
- Requesting an alternate form of the medication
Explanation: Answer reason: Esophageal varices are fragile and can bleed with irritation or trauma. Solid capsules can irritate the esophagus; a liquid or alternative route is safer. Therefore, request an alternate form of amoxicillin.
The nurse is caring for a client who is receiving procainamide (Pronestyl) intravenously. It is important for the nurse to monitor?
- Hourly urinary output
- Serum potassium levels
- Continuous EKG readings
- Neurological signs
Explanation: Answer reason: IV procainamide is a Class Ia antiarrhythmic that can cause conduction changes (QRS widening, heart block) and new arrhythmias; continuous ECG monitoring is required. Urine output, potassium, and neuro checks are not the immediate priority for safe administration.
Before administering digoxin (Lanoxin) to a client, which of the following nursing assessments is a PRIORITY?
- Auscultate breath sounds
- Check for bowel sounds
- Monitor the heart rate
- Measure the blood pressure
Explanation: Answer reason: Digoxin slows AV conduction and can cause bradycardia; the apical heart rate must be checked and the dose held if below 60 bpm.
An 82 year-old client is prescribed eye drops for treatment of glaucoma. What assessment is needed before the nurse begins teaching proper administration of the medication?
- Determine third party payment plan for this treatment
- The client's manual dexterity
- Proximity to health care services
- Ability to use visual assistive devices
Explanation: Answer reason: Elderly clients may have decreased finger dexterity, which can prevent accurate self-administration of eye drops; assessing manual dexterity guides teaching and potential assistance needs. Other options are less directly related to safe administration.
The nurse admits a hypertensive client who complains of dizziness after taking diltiazem (Cardizem). Which of the following is the MOST important information for the nurse to assess?
- Schedule for taking medicine
- Daily intake of potassium
- Activity and rest patterns
- Baseline heart rate
Explanation: Answer reason: Diltiazem can cause dizziness from hypotension/bradycardia; the priority assessment is whether the client is taking the medication as prescribed (timing/dose) to rule out dosing errors or inappropriate timing contributing to symptoms.
The physician has ordered transdermal nitroglycerin patches for a client. The nurse should instruct the client to?
- Remove the patch when swimming or bathing
- Apply the patch to any non-hairy area of the body
- Apply a second patch with chest pain
- Remove the patch if ankle edema occurs
Explanation: Answer reason: Transdermal nitroglycerin should be placed on clean, hairless skin to ensure consistent absorption. It is not removed for bathing, a second patch is not applied for chest pain, and ankle edema is not an indication to remove the patch.
The nurse prepares to administer eye drops to a six year-old child. The CORRECT way to give the eye drops is to instill them?
- Directly on the anterior surface of the eyeball
- In the corner where the lids meet
- Under the upper lid as it is pulled upward
- In the conjunctival sac as the lower lid is pulled down
Explanation: Answer reason: Ophthalmic drops are instilled into the conjunctival sac by pulling the lower lid down, avoiding contact with the cornea; placing them on the eyeball, in the canthus, or under the upper lid is incorrect.
The physician has ordered an iodine solution for a client scheduled to undergo a thyroidectomy. When administering this medication the nurse should?
- Provide the client with a straw for drinking the liquid
- Dilute it in milk and give on an empty stomach
- Dilute it in fruit juice and give with meals
- Administer at bedtime followed by an antacid
Explanation: Answer reason: Strong iodine solutions (e.g., Lugol's) should be diluted in fruit juice or other liquids and given with meals to mask taste and reduce GI irritation. Milk and antacids are not indicated; using only a straw does not address irritation or taste.
Heparin has been ordered for a client with pulmonary embolis. Which statement, if made by the graduate nurse, indicates a lack of understanding of the medication?
- I will administer the medication 1-2 inches away from the umbilicus.
- I will administer the medication in the abdomen.
- I will check the PTT before administering the medication.
- I will need to aspirate when I give Heparin.
Explanation: Answer reason: Heparin injections should not be aspirated because this increases the risk of tissue damage and hematoma. The other statements reflect appropriate administration and monitoring practices.
What does the abbreviation h.s. mean in medication administration?
- At bed time
- Early morning
- After meals
- Before meals
Explanation: Answer reason: H.S. is the Latin abbreviation for hora somni, meaning at bedtime.
How long before mealtime should the nurse administer regular insulin, 10 units SQ?
- 15 minutes
- 30 minutes
- 45 minutes
- 60 minutes
Explanation: Answer reason: Regular insulin has an onset of 30–60 minutes; administer about 30 minutes before meals to match postprandial glucose rise.
What is the appropriate needle size for insulin injection?
- 18 G, 1.5 inches long
- 22 G, 1 inch long
- 22 G, 1.5 inches long
- 25 G, 5/8 inch long
Explanation: Answer reason: Insulin is given subcutaneously using a small-gauge, short needle; typical sizes are 25–31 G and 3/8–5/8 inch. Among the options, 25 G with a 5/8-inch length is appropriate.
The nurse will administer liquid medicine to a nine month-old child. Which of the following methods is appropriate?
- Allow the infant to drink the liquid from a medicine cup
- Administer the medication with a syringe next to the tongue
- Mix the medication with the infant's formula in the bottle
- Hold the child upright and administer the medicine by spoon
Explanation: Answer reason: For infants, an oral syringe allows accurate dosing and directing the liquid toward the side of the mouth next to the tongue/cheek reduces gagging and aspiration risk. Cup or spoon use is less accurate and may cause choking; mixing with formula risks incomplete dose if the bottle is not finished.
An elderly client is on an anticholinergic metered dose inhaler (MDI) for chronic obstructive pulmonary disease. The nurse suggests a spacer to?
- Decrease the time it takes for the administration of the medication
- Increase client compliance
- Improve the aerosol delivery from the MDI in clients who can't coordinate the MDI
- Prevent exacerbation of COPD
Explanation: Answer reason: Spacers hold the aerosol and synchronize inhalation with actuation, improving lung deposition for clients who cannot coordinate MDI use. They do not reduce administration time, directly increase compliance, or prevent COPD exacerbations.
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