Diagnostic Tests Practice Test 2
Diagnostic Tests NCLEX Practice Test
Diagnostic Tests is a key topic within the NCLEX test plan, located under Physiological Integrity → Reduction of Risk Potential → Diagnostic Tests. This section prepares patients, explains procedures, and interprets findings for safe follow-up care. Each test contains 50 questions designed to mirror the difficulty and variety of the real exam.
This is the 2nd part of the Diagnostic Tests series. To explore all practice tests under this topic, use the “Back to Main Topic” button at the end of the page.
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Diagnostic Tests Practice Test 2
The nurse is watching the cardiac monitor, and a client's rhythm suddenly changes. There are no P waves; instead, there are fibrillatory waves before each QRS complex. How should the nurse correctly interpret the client's heart rhythm?
- Atrial fibrillation
- Sinus tachycardia
- Ventricular fibrillation
- Ventricular tachycardia
Explanation: Answer reason: Absence of P waves with irregular fibrillatory (f) waves and preserved QRS complexes is characteristic of atrial fibrillation. Sinus tachycardia has visible P waves; ventricular fibrillation lacks organized QRS; ventricular tachycardia shows wide QRS without fibrillatory baseline.
A client with suspected bacterial meningitis has a lumbar puncture. Which cerebrospinal fluid (CSF) finding confirms bacterial meningitis?
- Clear fluid with normal glucose
- Cloudy fluid with increased WBCs and decreased glucose
- Bloody fluid with increased protein
- Clear fluid with increased red blood cells
Explanation: Answer reason: Bacterial meningitis produces purulent CSF with high WBCs (neutrophils) and low glucose due to bacterial consumption; fluid appears cloudy.
Tuberculin test is given on?
- Gluteal region
- Deltoid
- Thigh
- Forearm
Explanation: Answer reason: The Mantoux tuberculin skin test is administered intradermally on the volar aspect of the forearm.
In collecting a routine specimen for fecalysis, Which of the following, if done by a nurse, indicates inadequate knowledge and skills about the procedure?
- The nurse scoop the specimen specifically at the site with blood and mucus
- She took around 1 inch of specimen or a teaspoonful
- Ask the client to call her for the specimen after the client wiped off his anus with a tissue
- Ask the client to defecate in a bedpan, Secure a sterile container
Explanation: Answer reason: For stool collection, the client should be instructed not to contaminate the specimen with toilet tissue or other materials and to call before wiping, as tissue may be placed in the bedpan and contaminate the sample. Collect about 1 inch and include areas with blood or mucus; defecation in a clean bedpan with a specimen container is appropriate.
David, 68 year old male client is scheduled for Serum Lipid analysis. Which of the following health teaching is important to ensure accurate reading?
- Tell the patient to eat fatty meals 3 days prior to the procedure
- NPO for 12 hours pre procedure
- Ask the client to drink 1 glass of water 1 hour prior to the procedure
- Tell the client that the normal serum lipase level is 50 to 140 U/L
Explanation: Answer reason: For accurate serum lipid levels, the client should fast for about 12 hours prior to testing to avoid postprandial triglyceride elevation. Drinking a specific glass of water is unnecessary, eating fatty meals would distort results, and lipase ranges are unrelated.
In collecting a urine from a catheterized patient, Which of the following statement indicates an accurate performance of the procedure?
- Clamp above the port for 30 to 60 minutes before drawing the urine from the port
- Clamp below the port for 30 to 60 minutes before drawing the urine from the port
- Clamp above the port for 5 to 10 minutes before drawing the urine from the port
- Clamp below the port for 5 to 10 minutes before drawing the urine from the port
Explanation: Answer reason: For a sterile specimen from an indwelling catheter, clamp the tubing below the sampling port to allow fresh urine to collect in the tubing before aspirating from the port. Clamping above the port or for only 5–10 minutes is incorrect; 30–60 minutes ensures an adequate fresh sample.
Dr. Fabian De Las Santas, is about to conduct an ophthalmoscope examination. Which of the following, if done by a nurse, is a Correct preparation before the procedure?
- Provide the necessary draping to ensure privacy
- Open the windows, curtains and light to allow better illumination
- Pour warm water over the ophthalmoscope to ensure comfort
- Darken the room to provide better illumination
Explanation: Answer reason: For ophthalmoscopy, the room should be dark to allow maximal pupil dilation and enhance the red reflex, improving visualization. Opening windows increases ambient light; draping is not essential; warming the scope is unnecessary and unsafe.
After gastroscopy, an adaptation that indicates major complication would be?
- Difficulty in swallowing
- Increased gi motility
- Abdominal distention
- Nausea and vomiting
Explanation: Answer reason: Post-gastroscopy, severe dysphagia can indicate esophageal or pharyngeal perforation/edema—an urgent complication. The other findings are more common or minor after the procedure.
The nurse is caring for a client with a head injury who has an intracranial pressure monitor in place. Assessment reveals an ICP reading of 66. What is the nurse's best action?
- Notify the physician
- Record the reading as the only action
- Turn the client and recheck the reading
- Place the client supine
Explanation: Answer reason: Normal ICP is 5–15 mmHg; a reading of 66 is critically elevated and indicates risk of brain herniation. The priority is to urgently notify the provider for immediate interventions. Documenting only is unsafe, turning or placing supine can increase ICP.
The nurse caring for a client with a suspected peptic ulcer recognizes which exam as the one most reliable in diagnosing the disease?
- Upper-gastrointestinal x-ray
- Gastric analysis
- Endoscopy
- Barium studies
Explanation: Answer reason: Endoscopy (EGD) directly visualizes the mucosa and allows biopsy, making it the most accurate and reliable test for diagnosing peptic ulcers.
What is the most appropriate initial action if a client treated for anaphylactic reaction who has diabetes mellitus begins to exhibit restlessness, irritability, diaphoresis, and tremors?
- Administer prescribed dose of lorazepam for anxiety.
- Obtain blood glucose level to determine hypoglycemia.
- Initiate safety measures to prevent injury related to restlessness.
- Use therapeutic communication techniques to decrease irritability.
Explanation: Answer reason: The symptoms listed are classic adrenergic signs of hypoglycemia. For a client with diabetes, the priority initial action is to assess by checking the blood glucose so that hypoglycemia can be confirmed and treated promptly. Other options address anxiety or safety but do not first assess the likely physiological cause.
What is the most appropriate action if a client treated for anaphylaxis with epinephrine and who takes human regular insulin begins to exhibit restlessness, irritability, diaphoresis, and tremors?
- Administer prescribed dose of lorazepam for anxiety.
- Obtain blood glucose level to determine hypoglycemia.
- Initiate safety measures to prevent injury related to restlessness.
- Use therapeutic communication techniques to decrease irritability.
Explanation: Answer reason: Symptoms are adrenergic signs consistent with hypoglycemia, especially in a client on insulin; verify with a bedside blood glucose before other interventions.
Which statement by the client about colonoscopy indicates a need for further teaching?
- I will avoid solid food the day before the procedure.
- I will take a laxative as instructed.
- I can drive myself home afterward.
- This test helps detect colon cancer.
Explanation: Answer reason: Clients receive sedation for colonoscopy and must not drive afterward; they need a responsible adult to accompany them. The other statements accurately reflect prep and purpose.
Which of the following nursing intervention is important for a client scheduled to have a Guaiac Test?
- Avoid turnips, radish and horseradish 3 days before procedure
- Continue iron preparation to prevent further loss of Iron
- Do not eat read meat 12 hours before procedure
- Encourage caffeine and dark colored foods to produce accurate results
Explanation: Answer reason: For guaiac-based fecal occult blood testing, clients should avoid peroxidase-containing vegetables such as turnips, radishes, and horseradish for about 3 days to prevent false-positive results. Red meat should be avoided for 3 days (not just 12 hours). Iron and caffeine/dark foods are not encouraged as they can interfere with interpretation.
Which of the following is among an ideal way of collecting a urine specimen for culture and sensitivity?
- Use a clean container
- Discard the first flow of urine to ensure that the urine is not contaminated
- Collect around 30-50 ml of urine
- Add preservatives, refrigerate the specimen or add ice according to the agency’s protocol
Explanation: Answer reason: For a clean-catch midstream urine culture, the initial stream is voided to flush urethral contaminants; the midstream portion is collected. Other choices are either incomplete (sterile—not just clean—container) or context dependent.
Which of the following is incorrect with regards to proper urine testing using Benedict’s Solution?
- Heat around 5ml of Benedict’s solution together with the urine in a test tube
- Add 8 to 10 drops of urine
- Heat the Benedict’s solution without the urine to check if the solution is contaminated
- If the color remains BLUE, the result is POSITIVE
Explanation: Answer reason: Benedict’s test for reducing sugars turns from blue to green/yellow/orange/brick-red when positive; remaining blue indicates a negative result. The other steps describe correct procedure.
Where should the nurse place lead V1 for proper ECG lead placement in a patient with significant ST elevation?
- Fourth intercostal space right sternal border
- Fifth intercostal space midclavicular line
- Second intercostal space left sternal border
- Sixth intercostal space left anterior axillary line
Explanation: Answer reason: Precordial lead V1 is placed at the 4th intercostal space at the right sternal border. Other sites listed correspond to different leads (e.g., V4 at 5th ICS MCL, V2 at 4th ICS left sternal).
What is an important nursing intervention immediately after a lumbar puncture (spinal tap)?
- Keep the client lying flat for several hours
- Encourage the client to ambulate immediately
- Place the client in a sitting position
- Restrict fluid intake
Explanation: Answer reason: Following a lumbar puncture, keeping the client supine/flat for several hours helps prevent CSF leakage and post–dural puncture headache. Immediate ambulation or sitting increases risk, and fluids should be encouraged rather than restricted.
What is an important consideration for the nurse when conducting a non-stress test on a patient with gestational diabetes?
- Monitor the mother's blood glucose levels
- Increase the amount of food intake before the test
- Administer insulin during the test
- Avoid fetal monitoring altogether
Explanation: Answer reason: Maternal glucose levels directly affect fetal well-being and NST reactivity; monitoring prevents hypo/hyperglycemia during the test. Extra food or insulin during the test is not routine, and fetal monitoring is essential.
What information should the nurse include on the laboratory requisition when sending an arterial blood gas (ABG) specimen for analysis?
- Ventilator settings
- A list of client allergies
- The client's temperature
- The date and time the specimen was drawn
- Any supplemental oxygen the client is receiving
Explanation: Answer reason: ABG interpretation depends on the fraction of inspired oxygen (FiO2)/supplemental oxygen the client is receiving; this information must be documented for accurate analysis.
During a routine ECG, the nurse notes a baseline wandering pattern; what could be a potential reason for this finding?
- The patient is in atrial flutter.
- The electrodes are not secured properly.
- The patient has a well-functioning heart.
- The ECG machine needs recalibrating.
Explanation: Answer reason: Baseline wandering is an ECG artifact commonly caused by loose or poorly adhered electrodes, patient movement, or poor skin contact. Securing the electrodes corrects the issue.
What is a key piece of information a nurse should include when teaching a patient how to prepare for an ECG?
- You may have to fast before the ECG.
- You should wear tight-fitting clothing.
- Avoid lotions or oils on your skin prior to the ECG.
- There is no need to remove jewelry.
Explanation: Answer reason: Lotions and oils interfere with electrode adhesion and signal quality for ECGs. Fasting is not required, tight clothing is not recommended, and jewelry is typically removed.
While placing electrodes for an ECG, which area should the nurse avoid for optimal lead placement?
- On bony prominences
- Over major muscle groups
- On the skin with hair
- Over areas with skin conditions
Explanation: Answer reason: Electrodes should not be placed on irritated, injured, or diseased skin because adhesion and signal quality are poor and it increases risk of skin injury. Hair can be shaved and muscles/bony areas may be used if necessary, but diseased skin should be avoided.
An 18-year-old woman with a confirmed ectopic pregnancy treated with intramuscular methotrexate has a rising BhCG level 3 days after treatment; what is the most appropriate next management step?
- Second dose of methotrexate
- Transvaginal sonogram
- Laparoscopic salpingostomy
- Repeat BhCG in 48 hours
- Repeat BhCG in 72 hours
Explanation: Answer reason: With single-dose methotrexate for ectopic pregnancy, BhCG is checked on day 4 and day 7. A rise by day 3–4 can be expected; success is judged by a ≥15% decline from day 4 to day 7. Therefore, recheck BhCG in 72 hours (day 7).
Specimens of urine that are not taken directly to the laboratory are usually?
- Refrigerated.
- Discarded.
- Sealed in a sterile container.
- Shaken up.
Explanation: Answer reason: If urine cannot be sent immediately, it should be refrigerated to inhibit bacterial growth and chemical changes. It should not be discarded, shaking is unnecessary, and while sterile containers are used, refrigeration is the key action when there is a delay.
Which investigation should be done for a pregnant lady with jaundice?
- ALT, AST, ALP
- AST
- ALP
- GGT
Explanation: Answer reason: Initial evaluation of jaundice in pregnancy includes liver function tests—transaminases (ALT, AST) and alkaline phosphatase—to help characterize hepatocellular versus cholestatic patterns.
What is the significance of the D4 to D3 ratio in a clinical context?
- It helps assess fetal lung maturity
- It measures kidney function
- It evaluates liver enzyme levels
- It determines cardiac output
Explanation: Answer reason: The D4:D3 ratio is referenced as a parameter used to gauge fetal surfactant development, thus indicating fetal lung maturity.
How should the nurse interpret a Tensilon (edrophonium) test result when a client with myasthenia gravis becomes weaker after administration?
- Myasthenic crisis is present.
- Cholinergic crisis is present.
- This result is a normal finding.
- This result is a positive finding.
Explanation: Answer reason: Edrophonium increases acetylcholine. If weakness worsens after administration, it indicates excessive cholinergic stimulation (depolarization block), consistent with cholinergic crisis.
Why should a lumbar puncture not be performed on a patient with increased intracranial pressure?
- The patient may not be able to tolerate the test.
- Lumbar puncture may cause brain herniation.
- The patient cannot lie flat for the test.
- Lumbar puncture is not a conclusive test.
Explanation: Answer reason: With elevated intracranial pressure, removing CSF via lumbar puncture can rapidly lower spinal CSF pressure relative to intracranial pressure and precipitate downward brain herniation.
What is the best time for a nurse to collect a sputum specimen from a client?
- Early in the evening.
- Anytime during the day.
- In the morning, as soon as the client awakens.
- Before bedtime.
Explanation: Answer reason: Early-morning specimens are best because secretions pool overnight, producing the highest yield of sputum with minimal contamination from food or oral flora.
What is the primary purpose of the rheumatoid factor (RF) test?
- To diagnose infectious diseases
- To measure the integrity of the liver
- To assess the presence of rheumatoid arthritis
- To evaluate kidney function
Explanation: Answer reason: Rheumatoid factor is an autoantibody measured to support the diagnosis of rheumatoid arthritis; it is not a test for infections, liver integrity, or kidney function.
After administering prescribed intravenous fluids to a client admitted with septic shock, which laboratory test should the nurse anticipate the physician will order to evaluate the efficacy of the fluids?
- Serum troponin
- Serum glucose
- Serum white blood cells
- Serum lactic acid
Explanation: Answer reason: Lactate levels reflect tissue perfusion; decreasing serum lactic acid after fluids indicates improved oxygen delivery in septic shock. Troponin assesses myocardial injury, glucose reflects metabolic status, and WBC indicates infection/inflammation, not fluid resuscitation efficacy.
Why should nurse Jamie explain to the male client that self-monitoring of blood glucose is preferred over urine glucose testing?
- More accurate
- Can be done by the client
- It is easy to perform
- It is not influenced by drugs
Explanation: Answer reason: Blood glucose self-monitoring directly measures current blood glucose, unlike urine tests which reflect past levels and depend on renal threshold and hydration, making SMBG more accurate and reliable.
What is the preferred site for bone marrow aspiration in an obese patient?
- Posterior superior iliac crest
- Anterior iliac crest
- Inferior iliac crest
- None of the above
Explanation: Answer reason: In adults, including obese patients, the posterior superior iliac crest provides a large marrow cavity, reliable landmarks, and a safe approach, making it the preferred site for bone marrow aspiration.
After gastroscopy, which adaptation indicates a major complication?
- Nausea and vomiting
- Abdominal distention
- Increased GI motility
- Difficulty in swallowing
Explanation: Answer reason: Marked abdominal distention after EGD suggests serious complications such as perforation or bleeding leading to peritonitis. Nausea/vomiting and transient dysphagia can occur post-procedure and are less critical; increased GI motility is not a typical danger sign.
A 46-year-old, non-pregnant, morbidly obese woman presents with irregular periods over the past 6 months; what is the most appropriate initial management?
- Oral contraceptives
- Endometrial ablation
- Office hysteroscopy
- Dilation and curettage (D&C)
- Endometrial biopsy
Explanation: Answer reason: Women age 45 or older and those with risk factors for endometrial hyperplasia (e.g., obesity) who have abnormal uterine bleeding require endometrial sampling as the initial step to rule out hyperplasia or cancer before initiating treatment.
Which of the following is inappropriate in collecting mid stream clean catch urine specimen for urine analysis?
- Collect early in the morning, First voided specimen
- Do perineal care before specimen collection
- Collect 5 to 10 ml for urine
- Discard the first flow of the urine
Explanation: Answer reason: For a midstream clean-catch, the client performs perineal care, discards the initial urine, and collects a midstream sample (about 5–10 mL is adequate). Collecting the first voided specimen is not midstream and is therefore inappropriate.
Before scheduling a patient for endoscopic retrograde cholangiopancreatography (ERCP), which client parameter should the nurse assess?
- Bilirubin level
- Urine output
- Blood pressure
- Serum glucose
Explanation: Answer reason: ERCP evaluates the biliary and pancreatic ducts, commonly for obstructive jaundice. Assessing bilirubin level helps confirm obstruction and provides a baseline relevant to the procedure.
What is the correct placement for ECG lead V4?
- Fifth intercostal space at left midclavicular line
- Fifth intercostal space at left sternal border
- Fourth intercostal space at left midaxillary line
- Third intercostal space at left parasternal line
Explanation: Answer reason: V4 is placed in the 5th intercostal space at the left midclavicular line. (V1 4th ICS right sternal border; V2 4th ICS left sternal border; V5-V6 at 5th ICS anterior/midaxillary.).
Which of the following is a contraindication for lumbar puncture?
- Increased intracranial pressure (ICP) suspected
- Meningitis
- Guillain-Barré syndrome
- All of the above
Explanation: Answer reason: Lumbar puncture is contraindicated when increased ICP is suspected due to risk of brain herniation. Meningitis and Guillain-Barré syndrome are indications for LP, not contraindications.
If a PAP smear shows carcinoma in situ, what is the best next logical procedure?
- Conisation
- Colposcopy & biopsy
- Hysterectomy
- HPV viral DNA testing
Explanation: Answer reason: A cytologic finding of carcinoma in situ on Pap requires confirmation and assessment of lesion extent. The next step is colposcopy with directed biopsy. Conization or hysterectomy are treatments considered after histologic confirmation; HPV DNA testing is for screening/triage, not after CIS cytology.
What is the best position for a client undergoing a renal biopsy?
- Supine with knees bent
- Prone with pillow under abdomen
- Left lateral with leg extended
- Semi-Fowler’s with raised arm
Explanation: Answer reason: For a native kidney biopsy, the client is positioned prone with a pillow under the abdomen to elevate the flank, stabilize the kidney, and optimize access while reducing bleeding risk.
For a lumbar puncture in an infant, what position is best to expose the spine?
- Prone
- Side-lying curled up (fetal position)
- Supine with legs flexed
- High Fowler's with knees bent
Explanation: Answer reason: For lumbar puncture, flexing the infant in a side-lying fetal position widens the intervertebral spaces and exposes the lumbar area. Other positions do not open the spine adequately.
Which factor could potentially interfere with the accuracy of a TSH test in a patient with thyroid disease?
- Fasting before the test
- Use of anticoagulants
- Recent thyroid surgery
- Taking Vitamin D
Explanation: Answer reason: Certain anticoagulants (e.g., heparin) can interfere with immunoassays for thyroid tests and alter results, potentially affecting TSH accuracy. Fasting is not required for TSH, recent thyroid surgery does not interfere with the assay itself, and vitamin D has no known effect on TSH assay accuracy.
A patient presents with frequent atrial premature complexes; which laboratory test should the physician anticipate ordering?
- Complete Blood Count (CBC)
- Urinalysis
- Electrolyte panel
Explanation: Answer reason: PACs are often precipitated by electrolyte disturbances (e.g., K+, Mg2+). An electrolyte panel is the most relevant lab; CBC or urinalysis would not evaluate this cause.
In hypothyroid patients well controlled on thyroid hormone replacement, how often should thyroid function tests be performed during pregnancy?
- One day
- Every 1-2 weeks
- Every 1-2 months
- Once trimester
- They do not need to be checked
Explanation: Answer reason: During pregnancy, TSH/thyroid function should be monitored about every 4–6 weeks (especially early), which corresponds to every 1–2 months; more frequent than once per trimester.
Which test should the nurse describe that will evaluate the woman's organs of reproduction to determine the cause of infertility?
- Cystogram
- Culdoscopy
- Biopsy
- Hysterosalpingogram
Explanation: Answer reason: A hysterosalpingogram is an X-ray with contrast that outlines the uterine cavity and fallopian tube patency, used to evaluate causes of female infertility. A cystogram assesses the bladder, culdoscopy visualizes the pelvic cavity but not tubal patency, and biopsy samples tissue rather than evaluating reproductive tract patency.
Which type of cell in the spinal fluid suggests that a client with meningitis has become infected with viral meningitis?
- Platelets
- Neutrophils
- Red blood cells
- Lymphocytes
Explanation: Answer reason: Viral meningitis typically produces a lymphocytic pleocytosis in cerebrospinal fluid, whereas bacterial meningitis shows neutrophil predominance. Platelets and red blood cells are not indicators of viral meningitis.
A 26-year-old pregnant woman at 34 weeks’ gestation with a blood pressure of 142/94 mmHg presents to the clinic; what test should be checked next?
- Type and screen
- Complete blood count
- Liver function tests
- Urine dip
- Uric acid
Explanation: Answer reason: Hypertension at 34 weeks raises concern for preeclampsia; the immediate next test is a urine dip to screen for proteinuria. Other labs (CBC, LFTs, uric acid) are secondary evaluations.
A college student comes to the college health services with complaints of a severe headache, nausea, and photophobia. The physician orders a complete blood count (CBC) and a lumbar puncture (LP). Which of the following lab results would the nurse expect if a diagnosis of bacterial meningitis were made?
- Cerebrospinal fluid (CSF) cloudy, Hgb 13 g/dL, Hct 38%, WBC 18,000/mm3.
- CSF with RBCs present, Hgb 10 g/dL, Hct 37%, WBC 8,000/mm3.
- CSF cloudy, Hgb 12 g/dL, Hct 37%, WBC 7,000/mm3.
- CSF clear, Hgb 15 g/dL, Hct 40%, WBC 11,000/mm3.
Explanation: Answer reason: Bacterial meningitis typically shows cloudy CSF due to high neutrophils and a systemic leukocytosis. Option 1 matches these expected findings; other options show clear CSF, normal WBC, or RBCs from a traumatic tap.
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